New frontiers in Schistosoma genomics and transcriptomics

Detalhes bibliográficos
Autor(a) principal: Alves, Laila
Data de Publicação: 2012
Outros Autores: Mourão, Marina de Moraes, Oliveira, Guilherme Corrêa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7803
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz . Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brazil/Faculdade Infórium de Tecnologia. Belo Horizonte, MG, Brazil
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spelling Alves, LailaMourão, Marina de MoraesOliveira, Guilherme Corrêa de2014-06-06T17:14:43Z2014-06-06T17:14:43Z2012Hindawi Publishing Corporation1432-1955https://www.arca.fiocruz.br/handle/icict/780310.1155/2012/849132engHindawi Publishing CorporationNew frontiers in Schistosoma genomics and transcriptomicsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz . Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brazil/Faculdade Infórium de Tecnologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz . Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, BrazilSchistosomes are digenean blood flukes of aves and mammals comprising 23 species. Some species are causative agents of human schistosomiasis, the second major neglected disease affecting over 230 million people worldwide. Modern technologies including the sequencing and characterization of nucleic acids and proteins have allowed large-scale analyses of parasites and hosts, opening new frontiers in biological research with potential biomedical and biotechnological applications. Nuclear genomes of the three most socioeconomically important species (S. haematobium, S. japonicum, and S. mansoni) have been sequenced and are under intense investigation. Mitochondrial genomes of six Schistosoma species have also been completely sequenced and analysed from an evolutionary perspective. Furthermore, DNA barcoding of mitochondrial sequences is used for biodiversity assessment of schistosomes. Despite the efforts in the characterization of Schistosoma genomes and transcriptomes, many questions regarding the biology and evolution of this important taxon remain unanswered. This paper aims to discuss some advances in the schistosome research with emphasis on genomics and transcriptomics. It also aims to discuss the main challenges of the current research and to point out some future directions in schistosome studies.Schistosoma mansonischistosomiasisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALNew Frontiers in Schistosoma Genomics and Transcriptomics.pdfNew Frontiers in Schistosoma Genomics and Transcriptomics.pdfapplication/pdf1177475https://www.arca.fiocruz.br/bitstream/icict/7803/1/New%20Frontiers%20in%20Schistosoma%20Genomics%20and%20Transcriptomics.pdfe00472526d0067fc50d7ea537c8db7d5MD51New Frontiers in Schistosoma Genomics and Transcriptomics.pdfNew Frontiers in Schistosoma Genomics and Transcriptomics.pdfapplication/pdf1177475https://www.arca.fiocruz.br/bitstream/icict/7803/2/New%20Frontiers%20in%20Schistosoma%20Genomics%20and%20Transcriptomics.pdfe00472526d0067fc50d7ea537c8db7d5MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7803/3/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD53TEXTNew Frontiers in Schistosoma Genomics and Transcriptomics.pdf.txtNew Frontiers in Schistosoma Genomics and Transcriptomics.pdf.txtExtracted texttext/plain64038https://www.arca.fiocruz.br/bitstream/icict/7803/6/New%20Frontiers%20in%20Schistosoma%20Genomics%20and%20Transcriptomics.pdf.txt317aa8146989367d834154726982857fMD56THUMBNAILNew Frontiers in Schistosoma Genomics and Transcriptomics.pdf.jpgNew Frontiers in Schistosoma Genomics and Transcriptomics.pdf.jpgGenerated Thumbnailimage/jpeg1975https://www.arca.fiocruz.br/bitstream/icict/7803/5/New%20Frontiers%20in%20Schistosoma%20Genomics%20and%20Transcriptomics.pdf.jpg035eb1ac7ad83975473e94f46116bb7cMD55icict/78032018-04-06 11:25:52.734oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T14:25:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv New frontiers in Schistosoma genomics and transcriptomics
title New frontiers in Schistosoma genomics and transcriptomics
spellingShingle New frontiers in Schistosoma genomics and transcriptomics
Alves, Laila
Schistosoma mansoni
schistosomiasis
title_short New frontiers in Schistosoma genomics and transcriptomics
title_full New frontiers in Schistosoma genomics and transcriptomics
title_fullStr New frontiers in Schistosoma genomics and transcriptomics
title_full_unstemmed New frontiers in Schistosoma genomics and transcriptomics
title_sort New frontiers in Schistosoma genomics and transcriptomics
author Alves, Laila
author_facet Alves, Laila
Mourão, Marina de Moraes
Oliveira, Guilherme Corrêa de
author_role author
author2 Mourão, Marina de Moraes
Oliveira, Guilherme Corrêa de
author2_role author
author
dc.contributor.author.fl_str_mv Alves, Laila
Mourão, Marina de Moraes
Oliveira, Guilherme Corrêa de
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
schistosomiasis
topic Schistosoma mansoni
schistosomiasis
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz . Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brazil/Faculdade Infórium de Tecnologia. Belo Horizonte, MG, Brazil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-06-06T17:14:43Z
dc.date.available.fl_str_mv 2014-06-06T17:14:43Z
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dc.identifier.citation.fl_str_mv Hindawi Publishing Corporation
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7803
dc.identifier.issn.none.fl_str_mv 1432-1955
dc.identifier.doi.none.fl_str_mv 10.1155/2012/849132
identifier_str_mv Hindawi Publishing Corporation
1432-1955
10.1155/2012/849132
url https://www.arca.fiocruz.br/handle/icict/7803
dc.language.iso.fl_str_mv eng
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