Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation

Detalhes bibliográficos
Autor(a) principal: Bezerra, Marcus Rafael Lobo
Data de Publicação: 2019
Outros Autores: Maranhao, Andrea Queiroz, Studart, Igor Cabral, Pontes, Larissa Queiroz, Fonseca, Marcela Helena Gambim, Furtado, Gilvan Pessoa
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32708
Resumo: Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
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spelling Bezerra, Marcus Rafael LoboMaranhao, Andrea QueirozStudart, Igor CabralPontes, Larissa QueirozFonseca, Marcela Helena GambimFurtado, Gilvan Pessoa2019-04-24T13:51:08Z2019-04-24T13:51:08Z2019BEZERRA, M. R. L. et al. Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 4., 2019; SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 7., 2019, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2019. p. 102.https://www.arca.fiocruz.br/handle/icict/3270810.35259/isi.sact.2019_32708Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.Universidade Federal do Ceará. Fortaleza, CE, Brasil.Universidade de Brasília. Brasília, DF, Brasil.Universidade Federal do Ceará. Fortaleza, CE, Brasil.Universidade Federal do Ceará. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Fiocruz Ceará. Fortaleza, CE, Brasil.engFiocruz/Instituto de Tecnologia em ImunobiológicosPhage DisplayEvolução DirigidascFvPhage DisplayDirected EvolutionscFvTécnicas de Visualização da Superfície CelularAnticorpos de Cadeia ÚnicaConstruction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/32708/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALBIO_17.pdfapplication/pdf59388https://www.arca.fiocruz.br/bitstream/icict/32708/2/BIO_17.pdfef745e8e41b08f5808e2b5a1ca0f6a3bMD52TEXTBIO_17.pdf.txtBIO_17.pdf.txtExtracted texttext/plain3622https://www.arca.fiocruz.br/bitstream/icict/32708/3/BIO_17.pdf.txt11071fa16ca9d3975e5160677304d1ebMD53icict/327082023-04-26 17:00:37.275oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-26T20:00:37Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation
title Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation
spellingShingle Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation
Bezerra, Marcus Rafael Lobo
Phage Display
Evolução Dirigida
scFv
Phage Display
Directed Evolution
scFv
Técnicas de Visualização da Superfície Celular
Anticorpos de Cadeia Única
title_short Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation
title_full Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation
title_fullStr Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation
title_full_unstemmed Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation
title_sort Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation
author Bezerra, Marcus Rafael Lobo
author_facet Bezerra, Marcus Rafael Lobo
Maranhao, Andrea Queiroz
Studart, Igor Cabral
Pontes, Larissa Queiroz
Fonseca, Marcela Helena Gambim
Furtado, Gilvan Pessoa
author_role author
author2 Maranhao, Andrea Queiroz
Studart, Igor Cabral
Pontes, Larissa Queiroz
Fonseca, Marcela Helena Gambim
Furtado, Gilvan Pessoa
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Bezerra, Marcus Rafael Lobo
Maranhao, Andrea Queiroz
Studart, Igor Cabral
Pontes, Larissa Queiroz
Fonseca, Marcela Helena Gambim
Furtado, Gilvan Pessoa
dc.subject.other.pt_BR.fl_str_mv Phage Display
Evolução Dirigida
scFv
topic Phage Display
Evolução Dirigida
scFv
Phage Display
Directed Evolution
scFv
Técnicas de Visualização da Superfície Celular
Anticorpos de Cadeia Única
dc.subject.en.pt_BR.fl_str_mv Phage Display
Directed Evolution
scFv
dc.subject.decs.pt_BR.fl_str_mv Técnicas de Visualização da Superfície Celular
Anticorpos de Cadeia Única
description Os autores externos submeteram sua publicação para apresentação de trabalho no evento “International Symposium on Immunobiologicals”, que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fundação Oswaldo Cruz.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-04-24T13:51:08Z
dc.date.available.fl_str_mv 2019-04-24T13:51:08Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.citation.fl_str_mv BEZERRA, M. R. L. et al. Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 4., 2019; SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 7., 2019, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2019. p. 102.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32708
dc.identifier.doi.none.fl_str_mv 10.35259/isi.sact.2019_32708
identifier_str_mv BEZERRA, M. R. L. et al. Construction of a scFv library using directed evolution for rituximab-based therapies: using phage display towards antibody affinity maturation. In: INTERNATIONAL SYMPOSIUM ON IMMUNOBIOLOGICAL, 4., 2019; SEMINÁRIO ANUAL CIENTÍFICO E TECNOLÓGICO DE BIO-MANGUINHOS, 7., 2019, Rio de Janeiro. Anais... Rio de Janeiro: Bio-Manguinhos, 2019. p. 102.
10.35259/isi.sact.2019_32708
url https://www.arca.fiocruz.br/handle/icict/32708
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
publisher.none.fl_str_mv Fiocruz/Instituto de Tecnologia em Imunobiológicos
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