Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45516 |
Resumo: | Universidade do Estado do Rio de Janeiro. Instituto de Educação Física e Esportes. Laboratorio de Atividade Física e Promoção da Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. |
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França, Guilherme de OliveiraFrantz, Eliete Dalla CorteMagliano, D'Angelo CarloBargut, Thereza Cristina LonzettiSepúlveda-Fragoso, ViniciusSilvares, Raquel RangelDaliry, AnissaNascimento, Alessandro Rodrigues doBorges, Juliana Pereira2021-01-06T18:55:40Z2021-01-06T18:55:40Z2020FRANÇA, Guilherme de Oliveira et al. Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats. Life Sciences, n. 256, 117920, 9p, June 2020.0024-3205https://www.arca.fiocruz.br/handle/icict/4551610.1016/j.lfs.2020.117920engElsevierCardioproteçãoObesidadeObesidade sarcopenicaComposição corporalTreinamento intervalado de alta intensidadeLangendorffCardioprotectionObesitySarcopenic obesityHigh-intensity interval trainingBody compositionEffects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Instituto de Educação Física e Esportes. Laboratorio de Atividade Física e Promoção da Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Morfologia. Laboratório de Análises Morfológicas e Metabólicas. Niterói, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia. (In)activity and Exercise. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto Biomédico.Departamento de Morfologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Morfologia. Laboratório de Análises Morfológicas e Metabólicas. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Saude de Nova Friburgo. Departamento de Ciências Bàsicas. Nova Friburgo, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Morfologia. Laboratório de Análises Morfológicas e Metabólicas. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Educação Física e Esportes. Laboratorio de Atividade Física e Promoção da Saúde. Rio de Janeiro, RJ, Brasil.Aim: We investigated the effects of high-intensity interval and continuous short-term exercise on body composition and cardiac function after myocardial ischemia-reperfusion injury (IRI) in obese rats. Methods: Rats fed with a standard chow diet (SC) or high-fat diet (HFD) for 20 weeks underwent systolic blood pressure (SBP), glycemia and dual-energy X-ray absorptiometry analyses. Then, animals fed with HFD were subdivided into three groups: sedentary (HFD-SED); moderate-intensity continuous training (HFD-MICT); and high-intensity interval training (HFD-HIIT). Exercised groups underwent four isocaloric aerobic exercise sessions, in which HFD-MICT maintained the intensity continuously and HFD-HIIT alternated it. After exercise sessions, all groups underwent global IRI and myocardial infarct size (IS) was determined histologically. Fat and muscle mass were weighted, and protein levels involved in muscle metabolism were assessed in skeletal muscle. Results: HFD-fed versus SC-fed rats reduced lean body mass by 31% (P < 0.001), while SBP, glycemia and body fat percentage were increased by 10% (P=0.04), 30% (P=0.006) and 54% (P < 0.001); respectively. HFDinduced muscle atrophy was restored in exercised groups, as only HFD-SED presented lower gastrocnemius (32%; P=0.001) and quadriceps mass (62%; P < 0.001) than SC. PGC1-α expression was 2.7-fold higher in HFD-HIIT versus HFD-SED (P=0.04), whereas HFD-HIIT and HFD-MICT exhibited 1.7-fold increase in pmTORSer2481 levels compared to HFD-SED (P=0.04). Although no difference was detected among groups for IS (P=0.30), only HFD-HIIT preserved left-ventricle developed pressure after IRI (+0.7 mmHg; P=0.9). Significance: Short-term exercise, continuous or HIIT, restored HFD-induced muscle atrophy and increased mTOR expression, but only HIIT maintained myocardial contractility following IRI in obese animals.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45516/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRaquelSilvares_AlissaDaliry_etal_IOC_2020.pdfRaquelSilvares_AlissaDaliry_etal_IOC_2020.pdfapplication/pdf1421974https://www.arca.fiocruz.br/bitstream/icict/45516/2/RaquelSilvares_AlissaDaliry_etal_IOC_2020.pdfcf061d8ac36beeb48f28083003211baaMD52TEXTRaquelSilvares_AlissaDaliry_etal_IOC_2020.pdf.txtRaquelSilvares_AlissaDaliry_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats |
| title |
Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats |
| spellingShingle |
Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats França, Guilherme de Oliveira Cardioproteção Obesidade Obesidade sarcopenica Composição corporal Treinamento intervalado de alta intensidade Langendorff Cardioprotection Obesity Sarcopenic obesity High-intensity interval training Body composition |
| title_short |
Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats |
| title_full |
Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats |
| title_fullStr |
Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats |
| title_full_unstemmed |
Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats |
| title_sort |
Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats |
| author |
França, Guilherme de Oliveira |
| author_facet |
França, Guilherme de Oliveira Frantz, Eliete Dalla Corte Magliano, D'Angelo Carlo Bargut, Thereza Cristina Lonzetti Sepúlveda-Fragoso, Vinicius Silvares, Raquel Rangel Daliry, Anissa Nascimento, Alessandro Rodrigues do Borges, Juliana Pereira |
| author_role |
author |
| author2 |
Frantz, Eliete Dalla Corte Magliano, D'Angelo Carlo Bargut, Thereza Cristina Lonzetti Sepúlveda-Fragoso, Vinicius Silvares, Raquel Rangel Daliry, Anissa Nascimento, Alessandro Rodrigues do Borges, Juliana Pereira |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
França, Guilherme de Oliveira Frantz, Eliete Dalla Corte Magliano, D'Angelo Carlo Bargut, Thereza Cristina Lonzetti Sepúlveda-Fragoso, Vinicius Silvares, Raquel Rangel Daliry, Anissa Nascimento, Alessandro Rodrigues do Borges, Juliana Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Cardioproteção Obesidade Obesidade sarcopenica Composição corporal Treinamento intervalado de alta intensidade |
| topic |
Cardioproteção Obesidade Obesidade sarcopenica Composição corporal Treinamento intervalado de alta intensidade Langendorff Cardioprotection Obesity Sarcopenic obesity High-intensity interval training Body composition |
| dc.subject.en.pt_BR.fl_str_mv |
Langendorff Cardioprotection Obesity Sarcopenic obesity High-intensity interval training Body composition |
| description |
Universidade do Estado do Rio de Janeiro. Instituto de Educação Física e Esportes. Laboratorio de Atividade Física e Promoção da Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020 |
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2021-01-06T18:55:40Z |
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2021-01-06T18:55:40Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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FRANÇA, Guilherme de Oliveira et al. Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats. Life Sciences, n. 256, 117920, 9p, June 2020. |
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https://www.arca.fiocruz.br/handle/icict/45516 |
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0024-3205 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.lfs.2020.117920 |
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FRANÇA, Guilherme de Oliveira et al. Effects of short-term high-intensity interval and continuous exercise training on body composition and cardiac function in obese sarcopenic rats. Life Sciences, n. 256, 117920, 9p, June 2020. 0024-3205 10.1016/j.lfs.2020.117920 |
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