Sporotrichosis in the nasal mucosa: A singlecenter retrospective study of 37 cases from 1998 to 2020
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1371/journal.pntd.0011212 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58876 |
Resumo: | AOS is a productivity fellow from the National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico – CNPq), Brazil.RMZ-O was supported in part by CNPq [302796/2017-7] and Fundac¸ão Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro [FAPERJ E-26/202.527/2019].The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
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Izoton, Carlos Felipe GomesSousa, Antonio Xavier de BritoValete, Cláudia MariaSchubach, Armando de OliveiraProcópio-Azevedo, Anna CarolinaZancopé-Oliveira, Rosely MariaMacedo, Priscila Marques deGutierrez-Galhardo, Maria ClaraCastro-Alves, JulioAlmeida-Paes, RodrigoMartins, Ana Cristina da CostaFreitas, Dayvison Francis Saraiva2023-06-02T02:31:10Z2023-06-02T02:31:10Z2023IZOTON, Carlos Felipe Gomes et al. Sporotrichosis in the nasal mucosa: A single-center retrospective study of 37 cases from 1998 to 2020. PLoS Neglected Tropical Diseases, v. 17, n. 3, p. 1-21, Mar. 2023.1935-2727https://www.arca.fiocruz.br/handle/icict/5887610.1371/journal.pntd.00112121935-2735AOS is a productivity fellow from the National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico – CNPq), Brazil.RMZ-O was supported in part by CNPq [302796/2017-7] and Fundac¸ão Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro [FAPERJ E-26/202.527/2019].The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil / Instituto de Educação Médica, Rio de Janeiro, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina, Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Background: Sporotrichosis is a subcutaneous or implantation mycosis caused by some species of the genus Sporothrix. Rio de Janeiro state, Brazil, experiences hyperendemic levels of zoonotic sporotrichosis, with increasing cases of disseminated disease, especially in people living with HIV (PLHIV). Involvement of the nasal mucosa is rare and occurs isolated or in disseminated cases, with a delayed resolution. Methodology/principal findings: This study aimed to describe the epidemiological, clinical, and therapeutic profiles of 37 cases of sporotrichosis with involvement of the nasal mucosa treated at the ear, nose, and throat (ENT) outpatient clinic of the Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, from 1998 to 2020. Data were reviewed from the medical records and stored in a database. The Mann-Whitney test was used to compare the means of quantitative variables, and Pearson chi-square and Fisher's exact tests were used to verify the association between qualitative variables (p<0.05). Most patients were males, students or retirees, with a median age of 38 years, residents in the municipality of Rio de Janeiro, and infected through zoonotic transmission. Disseminated sporotrichosis forms in patients with comorbidities (mostly PLHIV) were more common than the isolated involvement of the mucosa. The main characteristics of lesions in the nasal mucosa were the presence/elimination of crusts, involvement of various structures, mixed appearance, and severe intensity. Due to therapeutic difficulty, itraconazole was combined with amphotericin B and/or terbinafine in most cases. Of the 37 patients, 24 (64.9%) healed, with a median of 61 weeks of treatment, 9 lost follow-up, 2 were still treating and 2 died. Conclusions: Immunosuppression was determinant to the outcome, with worse prognosis and lower probability of cure. Notably in this group, the systematization of the ENT examination for early identification of lesions is recommended to optimize the treatment and outcome of the disease.engPublic Library of ScienceSporotrichosis in the nasal mucosa: A singlecenter retrospective study of 37 cases from 1998 to 2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSporotrichosisMycosisGenus SporothrixHIV (PLHIV)Nasal mucosainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58876/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Carlos_Izoton_etal_INI_2023.pdfve_Carlos_Izoton_etal_INI_2023.pdfapplication/pdf1259932https://www.arca.fiocruz.br/bitstream/icict/58876/2/ve_Carlos_Izoton_etal_INI_2023.pdfc51930daa77c6d905e938a9a61b76a75MD52icict/588762023-06-01 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| dc.title.en_US.fl_str_mv |
Sporotrichosis in the nasal mucosa: A singlecenter retrospective study of 37 cases from 1998 to 2020 |
| title |
Sporotrichosis in the nasal mucosa: A singlecenter retrospective study of 37 cases from 1998 to 2020 |
| spellingShingle |
Sporotrichosis in the nasal mucosa: A singlecenter retrospective study of 37 cases from 1998 to 2020 Izoton, Carlos Felipe Gomes Sporotrichosis Mycosis Genus Sporothrix HIV (PLHIV) Nasal mucosa |
| title_short |
Sporotrichosis in the nasal mucosa: A singlecenter retrospective study of 37 cases from 1998 to 2020 |
| title_full |
Sporotrichosis in the nasal mucosa: A singlecenter retrospective study of 37 cases from 1998 to 2020 |
| title_fullStr |
Sporotrichosis in the nasal mucosa: A singlecenter retrospective study of 37 cases from 1998 to 2020 |
| title_full_unstemmed |
Sporotrichosis in the nasal mucosa: A singlecenter retrospective study of 37 cases from 1998 to 2020 |
| title_sort |
Sporotrichosis in the nasal mucosa: A singlecenter retrospective study of 37 cases from 1998 to 2020 |
| author |
Izoton, Carlos Felipe Gomes |
| author_facet |
Izoton, Carlos Felipe Gomes Sousa, Antonio Xavier de Brito Valete, Cláudia Maria Schubach, Armando de Oliveira Procópio-Azevedo, Anna Carolina Zancopé-Oliveira, Rosely Maria Macedo, Priscila Marques de Gutierrez-Galhardo, Maria Clara Castro-Alves, Julio Almeida-Paes, Rodrigo Martins, Ana Cristina da Costa Freitas, Dayvison Francis Saraiva |
| author_role |
author |
| author2 |
Sousa, Antonio Xavier de Brito Valete, Cláudia Maria Schubach, Armando de Oliveira Procópio-Azevedo, Anna Carolina Zancopé-Oliveira, Rosely Maria Macedo, Priscila Marques de Gutierrez-Galhardo, Maria Clara Castro-Alves, Julio Almeida-Paes, Rodrigo Martins, Ana Cristina da Costa Freitas, Dayvison Francis Saraiva |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Izoton, Carlos Felipe Gomes Sousa, Antonio Xavier de Brito Valete, Cláudia Maria Schubach, Armando de Oliveira Procópio-Azevedo, Anna Carolina Zancopé-Oliveira, Rosely Maria Macedo, Priscila Marques de Gutierrez-Galhardo, Maria Clara Castro-Alves, Julio Almeida-Paes, Rodrigo Martins, Ana Cristina da Costa Freitas, Dayvison Francis Saraiva |
| dc.subject.en.en_US.fl_str_mv |
Sporotrichosis Mycosis Genus Sporothrix HIV (PLHIV) Nasal mucosa |
| topic |
Sporotrichosis Mycosis Genus Sporothrix HIV (PLHIV) Nasal mucosa |
| description |
AOS is a productivity fellow from the National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientı´fico e Tecnolo´gico – CNPq), Brazil.RMZ-O was supported in part by CNPq [302796/2017-7] and Fundac¸ão Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro [FAPERJ E-26/202.527/2019].The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
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2023 |
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2023-06-02T02:31:10Z |
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2023-06-02T02:31:10Z |
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2023 |
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IZOTON, Carlos Felipe Gomes et al. Sporotrichosis in the nasal mucosa: A single-center retrospective study of 37 cases from 1998 to 2020. PLoS Neglected Tropical Diseases, v. 17, n. 3, p. 1-21, Mar. 2023. |
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https://www.arca.fiocruz.br/handle/icict/58876 |
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1935-2727 |
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10.1371/journal.pntd.0011212 |
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1935-2735 |
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IZOTON, Carlos Felipe Gomes et al. Sporotrichosis in the nasal mucosa: A single-center retrospective study of 37 cases from 1998 to 2020. PLoS Neglected Tropical Diseases, v. 17, n. 3, p. 1-21, Mar. 2023. 1935-2727 10.1371/journal.pntd.0011212 1935-2735 |
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