The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56845 |
Resumo: | Programa Pesquisa para o SUS. Conselho Nacional de Desenvolvimento Científico e Desenvolvimento Tecnológico (CNPq). Programa de Apoio a Núcleos de Excelência. |
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Dias, Tamiris T.Tauro, Laura B.Macêdo, Lara E. N.Brito, Liz O.Ribeiro, Victor H. O.Santos, Cleiton S.Nascimento, Leile C. JacobVilas-Boas, Letícia S.Amado, CaioBarbosa, Paula S.Reis, Joice N.Campos, Gubio SoaresRibeiro, Guilherme S.Siqueira, Isadora C.Silva, Luciano K.Reis, Mitermayer G.2023-02-02T19:19:21Z2023-02-02T19:19:21Z2022DIAS, Tamiris T. et al. The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series. Frontiers in Tropical Diseases, v. 3, p. 1-9, 2022.2673-7515https://www.arca.fiocruz.br/handle/icict/5684510.3389/fitd.2022.1023588Programa Pesquisa para o SUS. Conselho Nacional de Desenvolvimento Científico e Desenvolvimento Tecnológico (CNPq). Programa de Apoio a Núcleos de Excelência.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Laboratório de Análises Clínicas. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Escola de Biomedicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Escola de Biomedicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Farmácia. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil / School of Public Health. Yale University. New Haven. CT, United State.Background: Recently, different arboviruses became endemic in Brazil mostly causing acute febrile illnesses, however, neurological manifestations have also been reported. This study aimed to investigate which viruses were involved in the meningitis etiology and the contribution of the circulating arboviruses in Salvador, Bahia, Brazil. Methods: From June 2014 to February 2016, 170 patients with suspected viral meningitis were identified in Couto Maia Hospital, Salvador-BA, Brazil. Their CSF samples were investigated for possible viral etiology by reverse transcription-PCR (RT-PCR) for different arboviruses: DENV, ZIKV and CHIKV; and for the EV; and by PCR for the HHV1-5 complex (HSV1-2, VZV, EBV and CMV). Also, ELISA was carried out in a subgroup of remaining samples for detection of DENV IgM and NS1 antigen, CHIKV IgM and ZIKV IgM. Results: Thirty-seven patients were PCR or ELISA positive for at least one of the studied viruses (overall positivity 21.8%). EV was the agent most frequently detected (10 cases; 27.0%), along with all four DENV serotypes (10 cases; 27.0%); followed by CHIKV (6 cases; 16.2%), ZIKV (6 cases; 16.2%), and Varicella zoster virus (VZV) (1 case; 2.7%). Four cases (10.8%) presented viral co-infection detected: DENV1 + CHIKV, DENV1 + EV, DENV4 + ZIKV, and CHIKV + ZIKV. Arboviruses (DENV, CHIKV and ZIKV) accounted for the great majority of cases (26 cases; 70.3%) of all single and co-infections: DENV has been the most frequently detected arbovirus (13 cases; 35.1%). Among non-arboviral meningitis, the most common etiology was the EV (11 cases; 29.7%). Conclusions: Arboviruses accounted for the majority of identified viruses among patients with suspected viral meningitis. In areas where they are endemic it is crucial to increase viral surveillance and consider them in the differential diagnosis of meningitis.engFrontiers MediaMeningite viralArbovírusDiagnóstico molecularDiagnóstico sorológicoSérie de casosViral meningitisArbovirusesMolecular diagnosisSerological diagnosisCase serieMeningite viralArbovírusTécnicas de diagnóstico molecularTestes sorológicosThe emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case seriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALDias, T.T. The emergence of arboviruses...2022.pdfDias, T.T. The emergence of arboviruses...2022.pdfapplication/pdf594735https://www.arca.fiocruz.br/bitstream/icict/56845/2/Dias%2c%20T.T.%20The%20emergence%20of%20arboviruses...2022.pdf961b9bbab166e61867a9c4edd41776f6MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56845/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/568452023-03-15 14:32:51.691oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:51Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series |
| title |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series |
| spellingShingle |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series Dias, Tamiris T. Meningite viral Arbovírus Diagnóstico molecular Diagnóstico sorológico Série de casos Viral meningitis Arboviruses Molecular diagnosis Serological diagnosis Case serie Meningite viral Arbovírus Técnicas de diagnóstico molecular Testes sorológicos |
| title_short |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series |
| title_full |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series |
| title_fullStr |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series |
| title_full_unstemmed |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series |
| title_sort |
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series |
| author |
Dias, Tamiris T. |
| author_facet |
Dias, Tamiris T. Tauro, Laura B. Macêdo, Lara E. N. Brito, Liz O. Ribeiro, Victor H. O. Santos, Cleiton S. Nascimento, Leile C. Jacob Vilas-Boas, Letícia S. Amado, Caio Barbosa, Paula S. Reis, Joice N. Campos, Gubio Soares Ribeiro, Guilherme S. Siqueira, Isadora C. Silva, Luciano K. Reis, Mitermayer G. |
| author_role |
author |
| author2 |
Tauro, Laura B. Macêdo, Lara E. N. Brito, Liz O. Ribeiro, Victor H. O. Santos, Cleiton S. Nascimento, Leile C. Jacob Vilas-Boas, Letícia S. Amado, Caio Barbosa, Paula S. Reis, Joice N. Campos, Gubio Soares Ribeiro, Guilherme S. Siqueira, Isadora C. Silva, Luciano K. Reis, Mitermayer G. |
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author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Dias, Tamiris T. Tauro, Laura B. Macêdo, Lara E. N. Brito, Liz O. Ribeiro, Victor H. O. Santos, Cleiton S. Nascimento, Leile C. Jacob Vilas-Boas, Letícia S. Amado, Caio Barbosa, Paula S. Reis, Joice N. Campos, Gubio Soares Ribeiro, Guilherme S. Siqueira, Isadora C. Silva, Luciano K. Reis, Mitermayer G. |
| dc.subject.other.en_US.fl_str_mv |
Meningite viral Arbovírus Diagnóstico molecular Diagnóstico sorológico Série de casos |
| topic |
Meningite viral Arbovírus Diagnóstico molecular Diagnóstico sorológico Série de casos Viral meningitis Arboviruses Molecular diagnosis Serological diagnosis Case serie Meningite viral Arbovírus Técnicas de diagnóstico molecular Testes sorológicos |
| dc.subject.en.en_US.fl_str_mv |
Viral meningitis Arboviruses Molecular diagnosis Serological diagnosis Case serie |
| dc.subject.decs.en_US.fl_str_mv |
Meningite viral Arbovírus Técnicas de diagnóstico molecular Testes sorológicos |
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Programa Pesquisa para o SUS. Conselho Nacional de Desenvolvimento Científico e Desenvolvimento Tecnológico (CNPq). Programa de Apoio a Núcleos de Excelência. |
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2022 |
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2022 |
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2023-02-02T19:19:21Z |
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2023-02-02T19:19:21Z |
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DIAS, Tamiris T. et al. The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series. Frontiers in Tropical Diseases, v. 3, p. 1-9, 2022. |
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https://www.arca.fiocruz.br/handle/icict/56845 |
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2673-7515 |
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10.3389/fitd.2022.1023588 |
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DIAS, Tamiris T. et al. The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: a case series. Frontiers in Tropical Diseases, v. 3, p. 1-9, 2022. 2673-7515 10.3389/fitd.2022.1023588 |
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