Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems

Parameswaran, Poornima; Sklan, Ella; Wilkins, Courtney; Burgon, Trever; Samuel, Melanie A.; Lu, Rui; Ansel, K. Mark; Heissmeyer, Vigo; Einav, Shirit; Jackson, William; Doukas, Tammy; Paranjape, Suman; Polacek, Charlotta; Santos, Flávia Barreto dos; Jalili, Roxana; Babrzadeh, Farbod; Gharizadeh, Baback; Grimm, Dirk; Kay, Mark; Koike, Satoshi; Sarnow, Peter; Ronaghi, Mostafa; Ding, Shou-Wei; Harris, Eva; Chow, Marie; Diamond, Michael S.; Kirkegaard, Karla; Glenn, Jeffrey S.; Fire, Andrew Z.

Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems

Detalhes bibliográficos
Autor(a) principal:	Parameswaran, Poornima
Data de Publicação:	2010
Outros Autores:	Sklan, Ella, Wilkins, Courtney, Burgon, Trever, Samuel, Melanie A., Lu, Rui, Ansel, K. Mark, Heissmeyer, Vigo, Einav, Shirit, Jackson, William, Doukas, Tammy, Paranjape, Suman, Polacek, Charlotta, Santos, Flávia Barreto dos, Jalili, Roxana, Babrzadeh, Farbod, Gharizadeh, Baback, Grimm, Dirk, Kay, Mark, Koike, Satoshi, Sarnow, Peter, Ronaghi, Mostafa, Ding, Shou-Wei, Harris, Eva, Chow, Marie, Diamond, Michael S., Kirkegaard, Karla, Glenn, Jeffrey S., Fire, Andrew Z.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/22890
Resumo:	Stanford University School of Medicine. Department of Microbiology & Immunology. Stanford, CA, USA.

Metadados do item

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network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Parameswaran, PoornimaSklan, EllaWilkins, CourtneyBurgon, TreverSamuel, Melanie A.Lu, RuiAnsel, K. MarkHeissmeyer, VigoEinav, ShiritJackson, WilliamDoukas, TammyParanjape, SumanPolacek, CharlottaSantos, Flávia Barreto dosJalili, RoxanaBabrzadeh, FarbodGharizadeh, BabackGrimm, DirkKay, MarkKoike, SatoshiSarnow, PeterRonaghi, MostafaDing, Shou-WeiHarris, EvaChow, MarieDiamond, Michael S.Kirkegaard, KarlaGlenn, Jeffrey S.Fire, Andrew Z.2017-10-19T14:09:07Z2017-10-19T14:09:07Z2010PARAMESWARAN, Poornima; et al. Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems. PLoS Pathog, v.6, n.2, e1000764., 21p, Feb. 2010.1553-7366https://www.arca.fiocruz.br/handle/icict/2289010.1371/journal.ppat.10007641553-7374engPublic Library of ScienceVírus de RNASistemas vertebradosSistemas invertebradosHospedeirosRepertórios de RNA pequenosRNA virusesVertebrate systemsInvertebrate SystemsForty-One HostsSmall RNA RepertoiresSix RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systemsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleStanford University School of Medicine. Department of Microbiology & Immunology. Stanford, CA, USA.Stanford University School of Medicine. Department of Gastroenterology & Hepatology. Stanford, CA, USA / Tel-Aviv University. Departmento of Clinical Microbiology and Immunology. Tamat-Aviv, Tel-Aviv, Israel.University of Arkansas for Medical Sciences. Department of Microbiology & Immunology. Little Rock, Arkansas, USA / University of Washington School of Medicine. Department of Immunology. Seatke, Washington, USA,Stanford University School of Medicine. Department of Microbiology & Immunology. Stanford, CA, USA / Sg2, Evanston, IL, USA.Washington University School of Medicine. Washington University School of Medicine. St. Louis, MIssouri, USA / Harvard University. Cambridge, MA, USA.University of California at Riverside. Department of Plant Pathology & Microbiology. Riverside, CA, USA / Louisiania State University. Department of Biological Sciences. Baton Rouge, Louisiania, USA.University of California at San Francisco. Strategic Asthma Basic Research Center and the Department of Microbiology & Immunology. San Francisco, CA, USA.Institute of Molecular Immunology. Helmholtz Center Munich. German Research Center for Environmental Health. Munich, Germany.Stanford University School of Medicine. Department of Gastroenterology & Hepatology. Stanford, CA, USA..Stanford University School of Medicine. Department of Microbiology & Immunology. Stanford, CA, USA / Medical College of Wisonsin. Center for Biopreparedness and Infectious Disease. Departmento of Microbiology and Molecular Genetics. Milwaukee, WI, USA.Stanford University School of Medicine. Department of Microbiology & Immunology. Stanford, CA, USA / National Veterinary Institute. Lindholm, Denmark.University of California at Berkeley. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, USA / American Association for the Advancement of Sciences. Science and Technology Policy Fellowship Program. Washington, DC, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.University of California at Berkeley. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, USA.University of California at Berkeley. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, USA.Stanford University School of Medicine. Stanford Genome Technology Center. Stanford, CA, USA.Stanford University School of Medicine. Stanford Genome Technology Center. Stanford, CA, USA / University of heidelberg. Dept. of Virology. Heidelber, Germany.Stanford University School of Medicine. Stanford Genome Technology Center. Stanford, CA, USA.Stanford University School of Medicine. Departments of Pediatrics & Genetics. Stanford, CA, USA.Stanford University School of Medicine. Departments of Pediatrics & Genetics. Stanford, CA, USA.Tokyo Metropolitan Institute of Medical Science. Tokyo Metropolitan Organization for Medical Research. Tokio, Japan / Illumina, San Diego, California, United States of America.Stanford University School of Medicine. Department of Microbiology & Immunology. Stanford, CA, USA.Stanford University School of Medicine. Stanford Genome Technology Center. Stanford, CA, USA.University of California at Riverside. Department of Plant Pathology & Microbiology. Riverside, CA, USA.University of California at Berkeley. School of Public Health. Division of Infectious Diseases and Vaccinology. Berkeley, CA, USA.University of Arkansas for Medical Sciences. Department of Microbiology & Immunology. Little Rock, Arkansas, USA.Washington University School of Medicine. Departments of Medicine, Molecular Microbiology, Pathology & Immunology. St. Louis, Missouri, USA.Stanford University School of Medicine. Department of Microbiology & Immunology. Stanford, CA, USA.Stanford University School of Medicine. Department of Gastroenterology & Hepatology. Stanford, CA, USA..Stanford University School of Medicine. Departments of Pathology & Genetics. Stanford, CA, USA.We have used multiplexed high-throughput sequencing to characterize changes in small RNA populations that occur during viral infection in animal cells. Small RNA-based mechanisms such as RNA interference (RNAi) have been shown in plant and invertebrate systems to play a key role in host responses to viral infection. Although homologs of the key RNAi effector pathways are present in mammalian cells, and can launch an RNAi-mediated degradation of experimentally targeted mRNAs, any role for such responses in mammalian host-virus interactions remains to be characterized. Six different viruses were examined in 41 experimentally susceptible and resistant host systems. We identified virus-derived small RNAs (vsRNAs) from all six viruses, with total abundance varying from "vanishingly rare" (less than 0.1% of cellular small RNA) to highly abundant (comparable to abundant micro-RNAs "miRNAs"). In addition to the appearance of vsRNAs during infection, we saw a number of specific changes in host miRNA profiles. For several infection models investigated in more detail, the RNAi and Interferon pathways modulated the abundance of vsRNAs. We also found evidence for populations of vsRNAs that exist as duplexed siRNAs with zero to three nucleotide 3' overhangs. Using populations of cells carrying a Hepatitis C replicon, we observed strand-selective loading of siRNAs onto Argonaute complexes. These experiments define vsRNAs as one possible component of the interplay between animal viruses and their hosts.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/22890/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALflavia_barreto_etal_IOC_2010.pdfflavia_barreto_etal_IOC_2010.pdfapplication/pdf1978015https://www.arca.fiocruz.br/bitstream/icict/22890/2/flavia_barreto_etal_IOC_2010.pdf57c99b30222a3dea33108e7b9a584b93MD52TEXTflavia_barreto_etal_IOC_2010.pdf.txtflavia_barreto_etal_IOC_2010.pdf.txtExtracted texttext/plain111755https://www.arca.fiocruz.br/bitstream/icict/22890/3/flavia_barreto_etal_IOC_2010.pdf.txtd14492cd5874d495de05b8fc6c5383c4MD53icict/228902020-07-17 16:14:27.737oai:www.arca.fiocruz.br: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ório 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dc.title.pt_BR.fl_str_mv	Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
title	Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
spellingShingle	Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems Parameswaran, Poornima Vírus de RNA Sistemas vertebrados Sistemas invertebrados Hospedeiros Repertórios de RNA pequenos RNA viruses Vertebrate systems Invertebrate Systems Forty-One Hosts Small RNA Repertoires
title_short	Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
title_full	Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
title_fullStr	Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
title_full_unstemmed	Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
title_sort	Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems
author	Parameswaran, Poornima
author_facet	Parameswaran, Poornima Sklan, Ella Wilkins, Courtney Burgon, Trever Samuel, Melanie A. Lu, Rui Ansel, K. Mark Heissmeyer, Vigo Einav, Shirit Jackson, William Doukas, Tammy Paranjape, Suman Polacek, Charlotta Santos, Flávia Barreto dos Jalili, Roxana Babrzadeh, Farbod Gharizadeh, Baback Grimm, Dirk Kay, Mark Koike, Satoshi Sarnow, Peter Ronaghi, Mostafa Ding, Shou-Wei Harris, Eva Chow, Marie Diamond, Michael S. Kirkegaard, Karla Glenn, Jeffrey S. Fire, Andrew Z.
author_role	author
author2	Sklan, Ella Wilkins, Courtney Burgon, Trever Samuel, Melanie A. Lu, Rui Ansel, K. Mark Heissmeyer, Vigo Einav, Shirit Jackson, William Doukas, Tammy Paranjape, Suman Polacek, Charlotta Santos, Flávia Barreto dos Jalili, Roxana Babrzadeh, Farbod Gharizadeh, Baback Grimm, Dirk Kay, Mark Koike, Satoshi Sarnow, Peter Ronaghi, Mostafa Ding, Shou-Wei Harris, Eva Chow, Marie Diamond, Michael S. Kirkegaard, Karla Glenn, Jeffrey S. Fire, Andrew Z.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Parameswaran, Poornima Sklan, Ella Wilkins, Courtney Burgon, Trever Samuel, Melanie A. Lu, Rui Ansel, K. Mark Heissmeyer, Vigo Einav, Shirit Jackson, William Doukas, Tammy Paranjape, Suman Polacek, Charlotta Santos, Flávia Barreto dos Jalili, Roxana Babrzadeh, Farbod Gharizadeh, Baback Grimm, Dirk Kay, Mark Koike, Satoshi Sarnow, Peter Ronaghi, Mostafa Ding, Shou-Wei Harris, Eva Chow, Marie Diamond, Michael S. Kirkegaard, Karla Glenn, Jeffrey S. Fire, Andrew Z.
dc.subject.other.pt_BR.fl_str_mv	Vírus de RNA Sistemas vertebrados Sistemas invertebrados Hospedeiros Repertórios de RNA pequenos
topic	Vírus de RNA Sistemas vertebrados Sistemas invertebrados Hospedeiros Repertórios de RNA pequenos RNA viruses Vertebrate systems Invertebrate Systems Forty-One Hosts Small RNA Repertoires
dc.subject.en.pt_BR.fl_str_mv	RNA viruses Vertebrate systems Invertebrate Systems Forty-One Hosts Small RNA Repertoires
description	Stanford University School of Medicine. Department of Microbiology & Immunology. Stanford, CA, USA.
publishDate	2010
dc.date.issued.fl_str_mv	2010
dc.date.accessioned.fl_str_mv	2017-10-19T14:09:07Z
dc.date.available.fl_str_mv	2017-10-19T14:09:07Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	PARAMESWARAN, Poornima; et al. Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems. PLoS Pathog, v.6, n.2, e1000764., 21p, Feb. 2010.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/22890
dc.identifier.issn.pt_BR.fl_str_mv	1553-7366
dc.identifier.doi.none.fl_str_mv	10.1371/journal.ppat.1000764
dc.identifier.eissn.none.fl_str_mv	1553-7374
identifier_str_mv	PARAMESWARAN, Poornima; et al. Six RNA Viruses and Forty-One Hosts: Viral Small RNAs and Modulation of Small RNA Repertoires in Vertebrate and Invertebrate Systems. PLoS Pathog, v.6, n.2, e1000764., 21p, Feb. 2010. 1553-7366 10.1371/journal.ppat.1000764 1553-7374
url	https://www.arca.fiocruz.br/handle/icict/22890
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Public Library of Science
publisher.none.fl_str_mv	Public Library of Science
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/22890/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/22890/2/flavia_barreto_etal_IOC_2010.pdf https://www.arca.fiocruz.br/bitstream/icict/22890/3/flavia_barreto_etal_IOC_2010.pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems

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