Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark

Detalhes bibliográficos
Autor(a) principal: Chaves, Anny Carolinny Tigre Almeida
Data de Publicação: 2019
Outros Autores: Rocha, Vinicius Pinto Costa, Bastos, Tanira Matutino, Soares, Milena Botelho Pereira, Rodrigues, Ana Carolina Borges da Cruz, Bezerra, Daniel Pereira, Silva Júnior, Lauro José Caires, Paula, Vanderlucia Fonseca de, Silva, Edson Roberto da, Queiroz, Raphael Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34737
Resumo: Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) and Conselho Nacional de Desenvolvimento Científico Tecnológico (CNPq).
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spelling Chaves, Anny Carolinny Tigre AlmeidaRocha, Vinicius Pinto CostaBastos, Tanira MatutinoSoares, Milena Botelho PereiraRodrigues, Ana Carolina Borges da CruzBezerra, Daniel PereiraSilva Júnior, Lauro José CairesPaula, Vanderlucia Fonseca deSilva, Edson Roberto daQueiroz, Raphael Ferreira2019-08-12T16:31:05Z2019-08-12T16:31:05Z2019CHAVES, Anny Carolinny Tigre Almeida et al. Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark. International Journal of Advanced Engineering Research and Science, v. 6, n. 6, p. 672-687, 2019.2349-6495https://www.arca.fiocruz.br/handle/icict/3473710.22161/ijaers.6.6.78Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) and Conselho Nacional de Desenvolvimento Científico Tecnológico (CNPq).State University of the Southwest of Bahia. Department of Biological Sciences. Jequié, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.State University of the Southwest of Bahia. Department of Sciences and Technologies. Jequié, BA, Brazil.State University of the Southwest of Bahia. Department of Sciences and Technologies. Jequié, BA, Brazil.University of São Paulo. Faculty of Animal Science and Food Engineering. Pirassununga, SP, Brazil.State University of the Southwest of Bahia. Department of Natural Sciences. Vitória da Conquista, BA, Brazil.Manilkara rufula belongs to family Sapotaceae and has received little attention regarding its pharmacological properties and chemical composition. Therefore, our objective was to determine the farmacological activities and preliminary chemical profile of the stem bark from M. rufula. The plant stem bark of M. rufula was collected and ethanolic extract and fractions were prepared. The antioxidant activity was determined by •DPPH and ABTS•+ scavenger methods and inhibition of β-carotene oxidation. The minimum inhibitory and bactericidal concentrations were estimated through the broth microdilution method against gram positive and negative bacteria. Cytotoxicity, antioxidant and cytoprotection potential were investigated on culture macrophages. Antiproliferative activity was evaluated by Alamar Blue method. The in vitro arginase activity from Leishmania amazonensis was determined in presence of the samples. In addition, their effects on survival of L. amazonensis and Trypanosoma cruzi amastigotes in mice macrophages were assessed. The preliminary phytochemical profile was evaluated by qualitative methods of classical phytochemistry, infrared spectroscopy, LC-MS/MS and CG-MS. The samples presented antioxidant, bactericidal, leishmanicidal and trypanocidal properties without toxic characteristics on normal cells. Triterpenes were observed in the hexane fraction, while glycosides, aromatic rings, fatty esters, proanthocyanidin dimers and trimers, catechin and various terpenes were observed in the other fractions.engSapotaceaeManilkara rufulaAtividades farmacológicasComposição químicaSapotaceaeManilkara rufulaPharmacological activitiesChemical compositionAntioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem barkinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/34737/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAnny, Carolinny Antioxidant, antibacterial....pdfAnny, Carolinny Antioxidant, antibacterial....pdfapplication/pdf413750https://www.arca.fiocruz.br/bitstream/icict/34737/2/Anny%2c%20Carolinny%20Antioxidant%2c%20antibacterial....pdfb9d851bdf0baf25e4f030bdc3dcebb9aMD52TEXTAnny, Carolinny Antioxidant, antibacterial....pdf.txtAnny, Carolinny Antioxidant, antibacterial....pdf.txtExtracted texttext/plain73170https://www.arca.fiocruz.br/bitstream/icict/34737/3/Anny%2c%20Carolinny%20Antioxidant%2c%20antibacterial....pdf.txt66f66758956b92fff158bb0e8ffd2340MD53icict/347372023-03-15 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dc.title.pt_BR.fl_str_mv Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark
title Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark
spellingShingle Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark
Chaves, Anny Carolinny Tigre Almeida
Sapotaceae
Manilkara rufula
Atividades farmacológicas
Composição química
Sapotaceae
Manilkara rufula
Pharmacological activities
Chemical composition
title_short Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark
title_full Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark
title_fullStr Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark
title_full_unstemmed Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark
title_sort Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark
author Chaves, Anny Carolinny Tigre Almeida
author_facet Chaves, Anny Carolinny Tigre Almeida
Rocha, Vinicius Pinto Costa
Bastos, Tanira Matutino
Soares, Milena Botelho Pereira
Rodrigues, Ana Carolina Borges da Cruz
Bezerra, Daniel Pereira
Silva Júnior, Lauro José Caires
Paula, Vanderlucia Fonseca de
Silva, Edson Roberto da
Queiroz, Raphael Ferreira
author_role author
author2 Rocha, Vinicius Pinto Costa
Bastos, Tanira Matutino
Soares, Milena Botelho Pereira
Rodrigues, Ana Carolina Borges da Cruz
Bezerra, Daniel Pereira
Silva Júnior, Lauro José Caires
Paula, Vanderlucia Fonseca de
Silva, Edson Roberto da
Queiroz, Raphael Ferreira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chaves, Anny Carolinny Tigre Almeida
Rocha, Vinicius Pinto Costa
Bastos, Tanira Matutino
Soares, Milena Botelho Pereira
Rodrigues, Ana Carolina Borges da Cruz
Bezerra, Daniel Pereira
Silva Júnior, Lauro José Caires
Paula, Vanderlucia Fonseca de
Silva, Edson Roberto da
Queiroz, Raphael Ferreira
dc.subject.other.pt_BR.fl_str_mv Sapotaceae
Manilkara rufula
Atividades farmacológicas
Composição química
topic Sapotaceae
Manilkara rufula
Atividades farmacológicas
Composição química
Sapotaceae
Manilkara rufula
Pharmacological activities
Chemical composition
dc.subject.en.pt_BR.fl_str_mv Sapotaceae
Manilkara rufula
Pharmacological activities
Chemical composition
description Fundação de Amparo a Pesquisa do Estado da Bahia (FAPESB) and Conselho Nacional de Desenvolvimento Científico Tecnológico (CNPq).
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-08-12T16:31:05Z
dc.date.available.fl_str_mv 2019-08-12T16:31:05Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CHAVES, Anny Carolinny Tigre Almeida et al. Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark. International Journal of Advanced Engineering Research and Science, v. 6, n. 6, p. 672-687, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34737
dc.identifier.issn.pt_BR.fl_str_mv 2349-6495
dc.identifier.doi.pt_BR.fl_str_mv 10.22161/ijaers.6.6.78
identifier_str_mv CHAVES, Anny Carolinny Tigre Almeida et al. Antioxidant, antibacterial, leishmanicidal and trypanocidal activities of extract and fractions of Manilkara rufula stem bark. International Journal of Advanced Engineering Research and Science, v. 6, n. 6, p. 672-687, 2019.
2349-6495
10.22161/ijaers.6.6.78
url https://www.arca.fiocruz.br/handle/icict/34737
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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