Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Basano, Sergio de Almeida
Data de Publicação: 2014
Outros Autores: Fontes, Gilberto, Medeiros, Jansen Fernandes, Camargo, Juliana Souza de Almeida Aranha, Vera, Luana Janaína Souza, Araújo, Marcos Paulo Parente, Parente, Maira Santiago Pires, Ferreira, Ricardo de Godoi Mattos, Crispim, Pedro di Tárique Barreto, Camargo, Luís Marcelo Aranha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13862
Resumo: 2017-11-30
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spelling Basano, Sergio de AlmeidaFontes, GilbertoMedeiros, Jansen FernandesCamargo, Juliana Souza de Almeida AranhaVera, Luana Janaína SouzaAraújo, Marcos Paulo ParenteParente, Maira Santiago PiresFerreira, Ricardo de Godoi MattosCrispim, Pedro di Tárique BarretoCamargo, Luís Marcelo Aranha2016-04-19T14:17:14Z2014MEDEIROS, J. F. et al. Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon. The American Journal of Tropical Medicine and Hygiene. v. 90, p. 1170-1175, 2014.https://www.arca.fiocruz.br/handle/icict/1386210.4269/ajtmh.13-0410engAmerican Journal of Tropical Medicine and HygieneMansonella ozzardiInfectionIvermectinBrazilian AmazonSustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2017-11-30Secretaria de Saúde do Estado de Rondônia. Porto Velho, RO, Brazil. / Faculdade São Lucas. Departamento de Medicina. Porto Velho, RO, Brazil.Universidade Federal de São João Del Rei. Divinópolis, MG, Brazil.Fundação Oswaldo Cruz. Porto Velho, RO, Brazil.Fundação Oswaldo Cruz. Porto Velho, RO, Brazil.Faculdade São Lucas. Porto Velho, RO, Brazil.Faculdade São Lucas. Porto Velho, RO, Brazil.Faculdade São Lucas. Porto Velho, RO, Brazil.Faculdade São Lucas. Porto Velho, RO, Brazil.Universidade Federal de Rondônia. Porto Velho, RO, Brazil.Faculdade São Lucas. Departamento de Medicina. Porto Velho, RO, Brasil. / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brazil.Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg/kg of ivermectin to reduce Mansonella ozzardi microfilaraemia in infected persons. A total of 74 patients were studied within the municipality of Lábrea, which is located in Amazonas State, Brazil. The patients were treated with ivermectin after detection of the parasite by blood examination. Significant microfilaraemia reduction was observed and its residual effect was maintained for at least 12 months. There was no significant change in the laboratory blood count, hepatic metabolites, and nitrogen-bounding compound excreta dosage values that could compromise the use of this drug, demonstrating that ivermectin has a low toxicity level.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13862/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSustained Clearance.pdfSustained Clearance.pdfapplication/pdf781069https://www.arca.fiocruz.br/bitstream/icict/13862/2/Sustained%20Clearance.pdfe3c4111b859b7b3bb4638646dd6fbdedMD52TEXTSustained Clearance.pdf.txtSustained Clearance.pdf.txtExtracted texttext/plain32723https://www.arca.fiocruz.br/bitstream/icict/13862/3/Sustained%20Clearance.pdf.txtdeedc2a60bc2d588437ccc3994162cd2MD53icict/138622021-02-10 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dc.title.pt_BR.fl_str_mv Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon
title Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon
spellingShingle Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon
Basano, Sergio de Almeida
Mansonella ozzardi
Infection
Ivermectin
Brazilian Amazon
title_short Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon
title_full Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon
title_fullStr Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon
title_full_unstemmed Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon
title_sort Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon
author Basano, Sergio de Almeida
author_facet Basano, Sergio de Almeida
Fontes, Gilberto
Medeiros, Jansen Fernandes
Camargo, Juliana Souza de Almeida Aranha
Vera, Luana Janaína Souza
Araújo, Marcos Paulo Parente
Parente, Maira Santiago Pires
Ferreira, Ricardo de Godoi Mattos
Crispim, Pedro di Tárique Barreto
Camargo, Luís Marcelo Aranha
author_role author
author2 Fontes, Gilberto
Medeiros, Jansen Fernandes
Camargo, Juliana Souza de Almeida Aranha
Vera, Luana Janaína Souza
Araújo, Marcos Paulo Parente
Parente, Maira Santiago Pires
Ferreira, Ricardo de Godoi Mattos
Crispim, Pedro di Tárique Barreto
Camargo, Luís Marcelo Aranha
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Basano, Sergio de Almeida
Fontes, Gilberto
Medeiros, Jansen Fernandes
Camargo, Juliana Souza de Almeida Aranha
Vera, Luana Janaína Souza
Araújo, Marcos Paulo Parente
Parente, Maira Santiago Pires
Ferreira, Ricardo de Godoi Mattos
Crispim, Pedro di Tárique Barreto
Camargo, Luís Marcelo Aranha
dc.subject.other.en.fl_str_mv Mansonella ozzardi
Infection
Ivermectin
Brazilian Amazon
topic Mansonella ozzardi
Infection
Ivermectin
Brazilian Amazon
description 2017-11-30
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2016-04-19T14:17:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MEDEIROS, J. F. et al. Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon. The American Journal of Tropical Medicine and Hygiene. v. 90, p. 1170-1175, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13862
dc.identifier.doi.none.fl_str_mv 10.4269/ajtmh.13-0410
identifier_str_mv MEDEIROS, J. F. et al. Sustained Clearance of Mansonella ozzardi Infection after Treatment with Ivermectin in the Brazilian Amazon. The American Journal of Tropical Medicine and Hygiene. v. 90, p. 1170-1175, 2014.
10.4269/ajtmh.13-0410
url https://www.arca.fiocruz.br/handle/icict/13862
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv American Journal of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Journal of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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