Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury

Detalhes bibliográficos
Autor(a) principal: Spieth, Peter M.
Data de Publicação: 2009
Outros Autores: Carvalho, Alysson R., Pelosi, Paolo, Hoehn, Catharina, Meissner, Christoph, Kasper, Michael, Hubler, Matthias, Neindorff, Matthias von, Dassow, Constanze, Barrenschee, Martina, Uhlig, Stefan, Koch, Thea, Abreu, Marcelo Gama de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/38741
Resumo: Alysson R. Carvalho. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Spieth, Peter M.Carvalho, Alysson R.Pelosi, PaoloHoehn, CatharinaMeissner, ChristophKasper, MichaelHubler, MatthiasNeindorff, Matthias vonDassow, ConstanzeBarrenschee, MartinaUhlig, StefanKoch, TheaAbreu, Marcelo Gama de2019-12-20T12:25:04Z2019-12-20T12:25:04Z2009SPIETH, Peter M. et al. Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury. American Journal of Respiratory and Critical Care Medicine, v. 179, p. 684-693, 2009.1073-449Xhttps://www.arca.fiocruz.br/handle/icict/3874110.1164/rccm.200806-975OC1535-4970Alysson R. Carvalho. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.University Hospital Dresden. Department of Anesthesiology and Intensive Care Therapy. Dresden, Germany.University Hospital Dresden. Department of Anesthesiology and Intensive Care Therapy. Dresden, Germany.University of Insubria. Department of Ambient, Health and Safety. Varese, Italy.University Hospital Dresden. Department of Anesthesiology and Intensive Care Therapy. Dresden, Germany.University Hospital Dresden. Department of Anesthesiology and Intensive Care Therapy. Dresden, Germany.University of Dresden. Institute of Anatomy. Dresden, Germany.University Hospital Dresden. Department of Anesthesiology and Intensive Care Therapy. Dresden, Germany.University Hospital Dresden. Department of Anesthesiology and Intensive Care Therapy. Dresden, Germany.University of Aachen. Institute of Pharmacology and Toxicology. Aachen, Germany.University of Aachen. Institute of Pharmacology and Toxicology. Aachen, Germany.University of Aachen. Institute of Pharmacology and Toxicology. Aachen, Germany.University Hospital Dresden. Department of Anesthesiology and Intensive Care Therapy. Dresden, Germany.University Hospital Dresden. Department of Anesthesiology and Intensive Care Therapy. Dresden, Germany.Rationale: Noisy ventilation with variable VT may improve respiratory function in acute lung injury. Objectives: To determine the impact of noisy ventilation on respiratory functionand its biological effects on lung parenchyma compared with conventional protective mechanical ventilation strategies. Methods: In a porcine surfactant depletion model of lung injury, we randomly combined noisy ventilation with the ARDS Network protocol or the open lung approach (n 5 9 per group). Measurements and Main Results: Respiratory mechanics, gas exchange, and distribution of pulmonary blood flow were measured at intervals over a 6-hour period. Postmortem, lung tissue was analyzed to determine histological damage, mechanical stress, and inflammation. We found that,at comparable minute ventilation, noisy ventilation(1) improved arterial oxygenation and reduced mean inspiratory peak airway pressure and elastance of the respiratory system compared with the ARDS Network protocol and the open lung approach, (2) redistributed pulmonary blood flow to caudal zones compared with the ARDS Network protocol and to peripheral ones compared with the open lung approach, (3) reduced histological damage in comparison to both protective ventilation strategies, and (4) did not increase lung inflammation or mechanical stress. Conclusions: Noisy ventilation with variable VT and fixed respiratory frequency improves respiratory function and reduces histological damage compared with standard protective ventilation strategies.engAmerican Thoracic SocietyVariable tidal volumes improve lung protective ventilation strategies in experimental lung injuryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMechanical ventilationAcute lung injuryExperimental modelVariable ventilationInflammationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/38741/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Spieth_Peter_etal_INI_v_2009.pdfve_Spieth_Peter_etal_INI_v_2009.pdfapplication/pdf1110615https://www.arca.fiocruz.br/bitstream/icict/38741/2/ve_Spieth_Peter_etal_INI_v_2009.pdf5b89e0867f28624b1b5a89da559f85e7MD52TEXTve_Spieth_Peter_etal_INI_v_2009.pdf.txtve_Spieth_Peter_etal_INI_v_2009.pdf.txtExtracted texttext/plain47688https://www.arca.fiocruz.br/bitstream/icict/38741/3/ve_Spieth_Peter_etal_INI_v_2009.pdf.txtdbabf638b723c4089f8df5ec599b8c27MD53icict/387412019-12-21 02:02:45.077oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-12-21T05:02:45Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
title Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
spellingShingle Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
Spieth, Peter M.
Mechanical ventilation
Acute lung injury
Experimental model
Variable ventilation
Inflammation
title_short Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
title_full Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
title_fullStr Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
title_full_unstemmed Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
title_sort Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
author Spieth, Peter M.
author_facet Spieth, Peter M.
Carvalho, Alysson R.
Pelosi, Paolo
Hoehn, Catharina
Meissner, Christoph
Kasper, Michael
Hubler, Matthias
Neindorff, Matthias von
Dassow, Constanze
Barrenschee, Martina
Uhlig, Stefan
Koch, Thea
Abreu, Marcelo Gama de
author_role author
author2 Carvalho, Alysson R.
Pelosi, Paolo
Hoehn, Catharina
Meissner, Christoph
Kasper, Michael
Hubler, Matthias
Neindorff, Matthias von
Dassow, Constanze
Barrenschee, Martina
Uhlig, Stefan
Koch, Thea
Abreu, Marcelo Gama de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Spieth, Peter M.
Carvalho, Alysson R.
Pelosi, Paolo
Hoehn, Catharina
Meissner, Christoph
Kasper, Michael
Hubler, Matthias
Neindorff, Matthias von
Dassow, Constanze
Barrenschee, Martina
Uhlig, Stefan
Koch, Thea
Abreu, Marcelo Gama de
dc.subject.en.pt_BR.fl_str_mv Mechanical ventilation
Acute lung injury
Experimental model
Variable ventilation
Inflammation
topic Mechanical ventilation
Acute lung injury
Experimental model
Variable ventilation
Inflammation
description Alysson R. Carvalho. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2019-12-20T12:25:04Z
dc.date.available.fl_str_mv 2019-12-20T12:25:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SPIETH, Peter M. et al. Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury. American Journal of Respiratory and Critical Care Medicine, v. 179, p. 684-693, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/38741
dc.identifier.issn.pt_BR.fl_str_mv 1073-449X
dc.identifier.doi.none.fl_str_mv 10.1164/rccm.200806-975OC
dc.identifier.eissn.none.fl_str_mv 1535-4970
identifier_str_mv SPIETH, Peter M. et al. Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury. American Journal of Respiratory and Critical Care Medicine, v. 179, p. 684-693, 2009.
1073-449X
10.1164/rccm.200806-975OC
1535-4970
url https://www.arca.fiocruz.br/handle/icict/38741
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Thoracic Society
publisher.none.fl_str_mv American Thoracic Society
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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