Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/17854 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Silva, Kleverton Ribeiro daMendonça, Vitor Rosa Ramos deSilva, Kellen MatuzzyNascimento, Leopoldo Fabrício Marçal doSousa, Antonio Ferreira MendesPinho, Flaviane Alves deBarral Netto, ManoelBarral, Aldina Maria PradoCruz, Maria do Socorro Pires E2017-02-20T12:41:54Z2017-02-20T12:41:54Z2017SILVA, K. R. et al. Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil. Memórias do Instituto Oswaldo Cruz, v. 112, n. 1 p. 53-62, 2017.0074-0276https://www.arca.fiocruz.br/handle/icict/1785410.1590/0074-02760160305engInstituto Oswaldo CruzLeishmaniose visceral caninaEscore clínicoDiagnósticoSinais clínicosCanine visceral leishmaniasisClinical scoreDiagnosisClinical signsScoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Piauí. Departamento de Morfofisiologia Veterinária. Teresina, PI, BrasilUniversidade Federal do Piauí. Departamento de Morfofisiologia Veterinária. Teresina, PI, BrasilUniversidade Federal do Piauí. Picos, PI, BrasilUniversidade Federal do Piauí. Departamento de Morfofisiologia Veterinária. Teresina, PI, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, BrasilUniversidade Federal do Piauí. Departamento de Morfofisiologia Veterinária. Teresina, PI, BrasilCanine visceral leishmaniasis (CVL) diagnosis is still a challenge in endemic areas with limited diagnostic resources. This study proposes a score with the potential to distinguish positive CVL cases from negative ones. We studied 265 dogs that tested positive for CVL on ELISA and parasitological tests. A score ranging between 0 and 19 was recorded on the basis of clinical signs. Dogs with CVL had an overall higher positivity of the majority of clinical signs than did dogs without CVL or with ehrlichiosis. Clinical signs such as enlarged lymph nodes (83.93%), muzzle/ear lesions (55.36%), nutritional status (51.79%), bristle condition (57.14%), pale mucosal colour (48.21%), onychogryphosis (58.93%), skin lesion (39.28%), bleeding (12.50%), muzzle depigmentation (41.07%), alopecia (39.29%), blepharitis (21.43%), and keratoconjunctivitis (42.86%) were more frequent in dogs with CVL than in dogs with ehrlichiosis or without CVL. Moreover, the clinical score increased according to the positivity of all diagnostic tests (ELISA, p < 0.001; parasite culture, p = 0.0021; and smear, p = 0.0003). Onychogryphosis (long nails) [odds ratio (OR): 3.529; 95% confidence interval (CI): 1.832-6.796; p < 0.001], muzzle depigmentation (OR: 4.651; 95% CI: 2.218-9.750; p < 0.001), and keratoconjunctivitis (OR: 5.400; 95% CI: 2.549-11.441; p < 0.001) were highly associated with CVL. Interestingly, a score cut-off value ≥ 6 had an area under the curve of 0.717 (p < 0.0001), sensitivity of 60.71%, and specificity of 73.64% for CVL diagnosis. The clinical sign-based score for CVL diagnosis suggested herein can help veterinarians reliably identify dogs with CVL in endemic areas with limited diagnostic resources.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/17854/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva, KR Scoring clinical....pdfSilva, KR Scoring clinical....pdfapplication/pdf3469886https://www.arca.fiocruz.br/bitstream/icict/17854/2/Silva%2c%20KR%20Scoring%20clinical....pdf48ab7b4d2bb51cef3c0b0877d2258cbdMD52TEXTSilva, KR Scoring clinical....pdf.txtSilva, KR Scoring clinical....pdf.txtExtracted texttext/plain45151https://www.arca.fiocruz.br/bitstream/icict/17854/3/Silva%2c%20KR%20Scoring%20clinical....pdf.txt6bc5fea2318c3201a7e6efacab374f48MD53icict/178542023-03-15 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| dc.title.pt_BR.fl_str_mv |
Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil |
| title |
Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil |
| spellingShingle |
Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil Silva, Kleverton Ribeiro da Leishmaniose visceral canina Escore clínico Diagnóstico Sinais clínicos Canine visceral leishmaniasis Clinical score Diagnosis Clinical signs |
| title_short |
Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil |
| title_full |
Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil |
| title_fullStr |
Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil |
| title_full_unstemmed |
Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil |
| title_sort |
Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil |
| author |
Silva, Kleverton Ribeiro da |
| author_facet |
Silva, Kleverton Ribeiro da Mendonça, Vitor Rosa Ramos de Silva, Kellen Matuzzy Nascimento, Leopoldo Fabrício Marçal do Sousa, Antonio Ferreira Mendes Pinho, Flaviane Alves de Barral Netto, Manoel Barral, Aldina Maria Prado Cruz, Maria do Socorro Pires E |
| author_role |
author |
| author2 |
Mendonça, Vitor Rosa Ramos de Silva, Kellen Matuzzy Nascimento, Leopoldo Fabrício Marçal do Sousa, Antonio Ferreira Mendes Pinho, Flaviane Alves de Barral Netto, Manoel Barral, Aldina Maria Prado Cruz, Maria do Socorro Pires E |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Kleverton Ribeiro da Mendonça, Vitor Rosa Ramos de Silva, Kellen Matuzzy Nascimento, Leopoldo Fabrício Marçal do Sousa, Antonio Ferreira Mendes Pinho, Flaviane Alves de Barral Netto, Manoel Barral, Aldina Maria Prado Cruz, Maria do Socorro Pires E |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose visceral canina Escore clínico Diagnóstico Sinais clínicos |
| topic |
Leishmaniose visceral canina Escore clínico Diagnóstico Sinais clínicos Canine visceral leishmaniasis Clinical score Diagnosis Clinical signs |
| dc.subject.en.pt_BR.fl_str_mv |
Canine visceral leishmaniasis Clinical score Diagnosis Clinical signs |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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2017 |
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2017-02-20T12:41:54Z |
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2017-02-20T12:41:54Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SILVA, K. R. et al. Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil. Memórias do Instituto Oswaldo Cruz, v. 112, n. 1 p. 53-62, 2017. |
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https://www.arca.fiocruz.br/handle/icict/17854 |
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0074-0276 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/0074-02760160305 |
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SILVA, K. R. et al. Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil. Memórias do Instituto Oswaldo Cruz, v. 112, n. 1 p. 53-62, 2017. 0074-0276 10.1590/0074-02760160305 |
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