An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1371/journal.pntd.0006785 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/32980 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil. |
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Bahia, Ana C.Kubota, Marina S.Souza Neto, Jayme A.Koerich, Leonardo B.Barletta, Ana BeatrizAraújo, Helena R. C.Gonçalves, Caroline M.Ríos-Velásquez, Cláudia M.Pimenta, Paulo F. P.Traub-Csekö, Yara M.2019-05-07T13:54:39Z2019-05-07T13:54:39Z2018BAHIA, Ana C. et al. An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria. PLoS Negl Trop Dis., v. 12, n. 9, e0006785, 16p, Sept. 2018.1935-2727https://www.arca.fiocruz.br/handle/icict/3298010.1371/journal.pntd.00067851935-2735engPublic Library of ScienceAnopheles aquasalisImunidadePlasmodiumBacteriasAnopheles aquasalisImmunityPlasmodiumBacteriaGATA SerpenteAn Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteriainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ. Brasil.Universidade Federal de Minas Gerais. Instituto de Biologia. Laboratório de Fisiologia de Insetos Hematófagos. Belo Horizonte, MG, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo De Meis. Laboratório de Bioquímica de Artrópodes Hematófagos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas & Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Entomologia Médica. Belo Horizonte, MG, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Leônidas & Maria Deane. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil.Innate immunity is an ancient and conserved defense system that provides an early effective response against invaders. Many immune genes of Anopheles mosquitoes have been implicated in defense against a variety of pathogens, including plasmodia. Nevertheless, only recent work identified some immune genes of Anopheles aquasalis mosquitoes upon P. vivax infection. Among these was a GATA transcription factor gene, which is described here. This is an ortholog of GATA factor Serpent genes described in Drosophila melanogaster and Anopheles gambiae. Gene expression analyses showed an increase of GATA-Serpent mRNA in P. vivax-infected A. aquasalis and functional RNAi experiments identified this transcription factor as an important immune gene of A. aquasalis against both bacteria and P. vivax. Besides, we were able to identify an effect of GATA-Serpent knockdown on A. aquasalis hemocyte proliferation and differentiation. These findings expand our understanding of the poorly studied A. aquasalis-P. vivax interactions and uncover GATA-Serpent as a key player of the mosquito innate immune response.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32980/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALYaraM_Trau_Czeko_etal_IOC_2018.pdfYaraM_Trau_Czeko_etal_IOC_2018.pdfapplication/pdf4099866https://www.arca.fiocruz.br/bitstream/icict/32980/2/YaraM_Trau_Czeko_etal_IOC_2018.pdf16d64e1d666eaf92e75cd8b4e3e533c9MD52TEXTYaraM_Trau_Czeko_etal_IOC_2018.pdf.txtYaraM_Trau_Czeko_etal_IOC_2018.pdf.txtExtracted texttext/plain53094https://www.arca.fiocruz.br/bitstream/icict/32980/3/YaraM_Trau_Czeko_etal_IOC_2018.pdf.txtbe7f225dedb9137dd7fc344a8fe4319cMD53icict/329802019-05-08 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| dc.title.pt_BR.fl_str_mv |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria |
| title |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria |
| spellingShingle |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria Bahia, Ana C. Anopheles aquasalis Imunidade Plasmodium Bacterias Anopheles aquasalis Immunity Plasmodium Bacteria GATA Serpente |
| title_short |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria |
| title_full |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria |
| title_fullStr |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria |
| title_full_unstemmed |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria |
| title_sort |
An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria |
| author |
Bahia, Ana C. |
| author_facet |
Bahia, Ana C. Kubota, Marina S. Souza Neto, Jayme A. Koerich, Leonardo B. Barletta, Ana Beatriz Araújo, Helena R. C. Gonçalves, Caroline M. Ríos-Velásquez, Cláudia M. Pimenta, Paulo F. P. Traub-Csekö, Yara M. |
| author_role |
author |
| author2 |
Kubota, Marina S. Souza Neto, Jayme A. Koerich, Leonardo B. Barletta, Ana Beatriz Araújo, Helena R. C. Gonçalves, Caroline M. Ríos-Velásquez, Cláudia M. Pimenta, Paulo F. P. Traub-Csekö, Yara M. |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bahia, Ana C. Kubota, Marina S. Souza Neto, Jayme A. Koerich, Leonardo B. Barletta, Ana Beatriz Araújo, Helena R. C. Gonçalves, Caroline M. Ríos-Velásquez, Cláudia M. Pimenta, Paulo F. P. Traub-Csekö, Yara M. |
| dc.subject.other.pt_BR.fl_str_mv |
Anopheles aquasalis Imunidade Plasmodium Bacterias |
| topic |
Anopheles aquasalis Imunidade Plasmodium Bacterias Anopheles aquasalis Immunity Plasmodium Bacteria GATA Serpente |
| dc.subject.en.pt_BR.fl_str_mv |
Anopheles aquasalis Immunity Plasmodium Bacteria GATA Serpente |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil. |
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2018 |
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2018 |
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2019-05-07T13:54:39Z |
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2019-05-07T13:54:39Z |
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BAHIA, Ana C. et al. An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria. PLoS Negl Trop Dis., v. 12, n. 9, e0006785, 16p, Sept. 2018. |
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https://www.arca.fiocruz.br/handle/icict/32980 |
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1935-2727 |
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10.1371/journal.pntd.0006785 |
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1935-2735 |
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BAHIA, Ana C. et al. An Anopheles aquasalis GATA factor Serpent is required for immunity against Plasmodium and bacteria. PLoS Negl Trop Dis., v. 12, n. 9, e0006785, 16p, Sept. 2018. 1935-2727 10.1371/journal.pntd.0006785 1935-2735 |
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