Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity

Detalhes bibliográficos
Autor(a) principal: Harper, Bryan
Data de Publicação: 2015
Outros Autores: Thomas, Dennis, Chikkagoudar, Satish, Baker, Nathan, Tang, Kaizhi, Heredia-Langner, Alejandro, Lins, Roberto, Harper, Stacey
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44628
Resumo: Oregon State University. Corvallis, USA.
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spelling Harper, BryanThomas, DennisChikkagoudar, SatishBaker, NathanTang, KaizhiHeredia-Langner, AlejandroLins, RobertoHarper, Stacey2020-11-26T13:26:09Z2020-11-26T13:26:09Z2015HARPER, B. et al. Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity. Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology, v. 17, n. 6, p. 250, 2015.1388-0764https://www.arca.fiocruz.br/handle/icict/4462810.1007/s11051-015-3051-0porNanopartículasPeixe-ZebraToxicidadeInformáticaNanoparticleZebrafishToxicitySurface chemistryInformaticsNanopartículasPeixe-ZebraToxicidadeInformáticaComparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOregon State University. Corvallis, USA.Laboratório Nacional do Noroeste do Pacífico. Richland, WA, EUA.Laboratório Nacional do Noroeste do Pacífico. Richland, WA, EUA.Laboratório Nacional do Noroeste do Pacífico. Richland, WA, EUA.Intelligent Automation. Inc. Rockville, MD, USA.Laboratório Nacional do Noroeste do Pacífico. Richland, WA, EUA.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Oregon State University. Corvallis, USA.The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure-toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here, we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated EZ Metric scores, a combined measure of morbidity and mortality in developing embryonic zebrafish, were established at realistic exposure levels and used to develop a hazard ranking of diverse nanomaterial toxicity. Hazard ranking and clustering analysis of 68 diverse nanomaterials revealed distinct patterns of toxicity related to both the core composition and outermost surface chemistry of nanomaterials. The resulting clusters guided the development of a surface chemistry-based model of gold nanoparticle toxicity. Our findings suggest that risk assessments based on the size and core composition of nanomaterials alone may be wholly inappropriate, especially when considering complex engineered nanomaterials. Research should continue to focus on methodologies for determining nanomaterial hazard based on multiple sub-lethal responses following realistic, low-dose exposures, thus increasing the availability of quantitative measures of nanomaterial hazard to support the development of nanoparticle structure-activity relationships.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44628/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL26069453 2015 per-cha.roa.pdf26069453 2015 per-cha.roa.pdfapplication/pdf2109840https://www.arca.fiocruz.br/bitstream/icict/44628/2/26069453%202015%20per-cha.roa.pdfb762c052e33949aa01b9889c1324bcfaMD52TEXT26069453 2015 per-cha.roa.pdf.txt26069453 2015 per-cha.roa.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity
title Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity
spellingShingle Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity
Harper, Bryan
Nanopartículas
Peixe-Zebra
Toxicidade
Informática
Nanoparticle
Zebrafish
Toxicity
Surface chemistry
Informatics
Nanopartículas
Peixe-Zebra
Toxicidade
Informática
title_short Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity
title_full Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity
title_fullStr Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity
title_full_unstemmed Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity
title_sort Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity
author Harper, Bryan
author_facet Harper, Bryan
Thomas, Dennis
Chikkagoudar, Satish
Baker, Nathan
Tang, Kaizhi
Heredia-Langner, Alejandro
Lins, Roberto
Harper, Stacey
author_role author
author2 Thomas, Dennis
Chikkagoudar, Satish
Baker, Nathan
Tang, Kaizhi
Heredia-Langner, Alejandro
Lins, Roberto
Harper, Stacey
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Harper, Bryan
Thomas, Dennis
Chikkagoudar, Satish
Baker, Nathan
Tang, Kaizhi
Heredia-Langner, Alejandro
Lins, Roberto
Harper, Stacey
dc.subject.other.pt_BR.fl_str_mv Nanopartículas
Peixe-Zebra
Toxicidade
Informática
topic Nanopartículas
Peixe-Zebra
Toxicidade
Informática
Nanoparticle
Zebrafish
Toxicity
Surface chemistry
Informatics
Nanopartículas
Peixe-Zebra
Toxicidade
Informática
dc.subject.en.pt_BR.fl_str_mv Nanoparticle
Zebrafish
Toxicity
Surface chemistry
Informatics
dc.subject.decs.pt_BR.fl_str_mv Nanopartículas
Peixe-Zebra
Toxicidade
Informática
description Oregon State University. Corvallis, USA.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2020-11-26T13:26:09Z
dc.date.available.fl_str_mv 2020-11-26T13:26:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HARPER, B. et al. Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity. Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology, v. 17, n. 6, p. 250, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44628
dc.identifier.issn.pt_BR.fl_str_mv 1388-0764
dc.identifier.eissn.none.fl_str_mv 10.1007/s11051-015-3051-0
identifier_str_mv HARPER, B. et al. Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity. Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology, v. 17, n. 6, p. 250, 2015.
1388-0764
10.1007/s11051-015-3051-0
url https://www.arca.fiocruz.br/handle/icict/44628
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/44628/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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