Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.3390/cancers15092544 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/58747 |
Resumo: | Universidade Federal do Maranhão. Programa de Pós-Graduação Rede Nordeste de Biotecnologia (RENORBIO). São Luis, MA, Brasil. |
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Muniz Filho, Walbert EdsonSouza, Fernando AlmeidaVale, André Alvares MarquesVictor, Elis CabralRocha, Mirtes Castelo BrancoSilva, Gabriel XavierTeles, Amanda MaraNascimento, Flavia Raquel FernandesMoragas-Tellis, Carla JunqueiraChagas, Maria do Socorro dos SantosBehrens, Maria DutraHardoim, Daiana de JesusTaniwaki, Noemi NosomiLima, Josélia AlencarSilva, Ana Lucia AbreuCosta, Rui M. Gil daCalabrese, Kátia da SilvaSantos, Ana Paula Silva de AzevedoNascimento, Maria do Desterro Soares Brandão2023-05-26T15:59:10Z2023-05-26T15:59:10Z2023MUNIZ FILHO, Walbert Edson et al. Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model. Cancers, v. 15, 2544, p. 1 - 20, April 2023.2072-6694https://www.arca.fiocruz.br/handle/icict/5874710.3390/cancers15092544engMDPICâncerImunoproteçãoAçaíEuterpe oleraceaModelo de mouseAtividade antitumoralCancerImmunoprotectionEuterpe oleraceaAçaíMouse modelAntitumor activityAntitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Maranhão. Programa de Pós-Graduação Rede Nordeste de Biotecnologia (RENORBIO). São Luis, MA, Brasil.Universidade Estadual do Maranhão. Programa de Pós-Graduação em Ciência Animal. São Luis, MA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Labotarório de Protozoologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Laboratório de Imunologia Aplicada ao Câncer. São Luis, MA, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Laboratório de Imunologia Aplicada ao Câncer. São Luis, MA, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Laboratório de Imunologia Aplicada ao Câncer. São Luis, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação Rede Nordeste de Biotecnologia (RENORBIO). São Luis, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação Rede Nordeste de Biotecnologia (RENORBIO). São Luis, MA, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Laboratório de Imunofisiologia. São Luis, MA, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia Farmacêutica. Departamento de Produtos Naturais, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia Farmacêutica. Departamento de Produtos Naturais, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia Farmacêutica. Departamento de Produtos Naturais, Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Protozoologia. Rio de Janeiro, RJ, Brasil.Instituto Adolfo Lutz. Núcleo de Eletron Microscopia. São Paulo, SP, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.Universidade Estadual do Maranhão. Programa de Pós-Graduação em Ciência Animal. São Luis, MA, Brasil .Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil / Instituto do Porto. Centro de Investigação em Oncologia Portuguesa. Rede de Investigação em Saúde. Porto, Portugal.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Protozoologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Laboratório de Imunologia Aplicada ao Câncer. São Luis, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação Rede Nordeste de Biotecnologia (RENORBIO). São Luis, MA, Brasil / Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.Abstract: Euterpe oleracea (açaí) fruit has approximately 15% pulp, which is partly edible and commercialized, and 85% seeds. Although açaí seeds are rich in catechins—polyphenolic compounds with antioxidant, anti-inflammatory, and antitumor effects—almost 935,000 tons/year of seeds are discarded as industrial waste. This work evaluated the antitumor properties of E. oleracea in vitro and in vivo in a solid Ehrlich tumor in mice. The seed extract presented 86.26 0.189 mg of catechin/g of extract. The palm and pulp extracts did not exhibit in vitro antitumor activity, while the fruit and seed extracts showed cytotoxic effects on the LNCaP prostate cancer cell line, inducing mitochondrial and nuclear alterations. Oral treatments were performed daily at 100, 200, and 400 mg/kg of E. oleracea seed extract. The tumor development and histology were evaluated, along with immunological and toxicological parameters. Treatment at 400 mg/kg reduced the tumor size, nuclear pleomorphism, and mitosis figures, increasing tumor necrosis. Treated groups showed cellularity of lymphoid organs comparable to the untreated group, suggesting less infiltration in the lymph node and spleen and preservation of the bone marrow. The highest doses reduced IL-6 and induced IFN- suggesting antitumor and immunomodulatory effects. Thus, açaí seeds can be an important source of compounds with antitumor and immunoprotective properties.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58747/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALKatiaCalabrese_DaianaArdoim_etal_IOC_2023.pdfKatiaCalabrese_DaianaArdoim_etal_IOC_2023.pdfapplication/pdf3322304https://www.arca.fiocruz.br/bitstream/icict/58747/2/KatiaCalabrese_DaianaArdoim_etal_IOC_2023.pdf40f8c1463fb39cce292774c26f5e5153MD52icict/587472023-09-04 11:03:08.845oai:www.arca.fiocruz.br:icict/58747Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:03:08Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model |
| title |
Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model |
| spellingShingle |
Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model Muniz Filho, Walbert Edson Câncer Imunoproteção Açaí Euterpe oleracea Modelo de mouse Atividade antitumoral Cancer Immunoprotection Euterpe oleracea Açaí Mouse model Antitumor activity |
| title_short |
Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model |
| title_full |
Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model |
| title_fullStr |
Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model |
| title_full_unstemmed |
Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model |
| title_sort |
Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model |
| author |
Muniz Filho, Walbert Edson |
| author_facet |
Muniz Filho, Walbert Edson Souza, Fernando Almeida Vale, André Alvares Marques Victor, Elis Cabral Rocha, Mirtes Castelo Branco Silva, Gabriel Xavier Teles, Amanda Mara Nascimento, Flavia Raquel Fernandes Moragas-Tellis, Carla Junqueira Chagas, Maria do Socorro dos Santos Behrens, Maria Dutra Hardoim, Daiana de Jesus Taniwaki, Noemi Nosomi Lima, Josélia Alencar Silva, Ana Lucia Abreu Costa, Rui M. Gil da Calabrese, Kátia da Silva Santos, Ana Paula Silva de Azevedo Nascimento, Maria do Desterro Soares Brandão |
| author_role |
author |
| author2 |
Souza, Fernando Almeida Vale, André Alvares Marques Victor, Elis Cabral Rocha, Mirtes Castelo Branco Silva, Gabriel Xavier Teles, Amanda Mara Nascimento, Flavia Raquel Fernandes Moragas-Tellis, Carla Junqueira Chagas, Maria do Socorro dos Santos Behrens, Maria Dutra Hardoim, Daiana de Jesus Taniwaki, Noemi Nosomi Lima, Josélia Alencar Silva, Ana Lucia Abreu Costa, Rui M. Gil da Calabrese, Kátia da Silva Santos, Ana Paula Silva de Azevedo Nascimento, Maria do Desterro Soares Brandão |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Muniz Filho, Walbert Edson Souza, Fernando Almeida Vale, André Alvares Marques Victor, Elis Cabral Rocha, Mirtes Castelo Branco Silva, Gabriel Xavier Teles, Amanda Mara Nascimento, Flavia Raquel Fernandes Moragas-Tellis, Carla Junqueira Chagas, Maria do Socorro dos Santos Behrens, Maria Dutra Hardoim, Daiana de Jesus Taniwaki, Noemi Nosomi Lima, Josélia Alencar Silva, Ana Lucia Abreu Costa, Rui M. Gil da Calabrese, Kátia da Silva Santos, Ana Paula Silva de Azevedo Nascimento, Maria do Desterro Soares Brandão |
| dc.subject.other.en_US.fl_str_mv |
Câncer Imunoproteção Açaí Euterpe oleracea Modelo de mouse Atividade antitumoral |
| topic |
Câncer Imunoproteção Açaí Euterpe oleracea Modelo de mouse Atividade antitumoral Cancer Immunoprotection Euterpe oleracea Açaí Mouse model Antitumor activity |
| dc.subject.en.en_US.fl_str_mv |
Cancer Immunoprotection Euterpe oleracea Açaí Mouse model Antitumor activity |
| description |
Universidade Federal do Maranhão. Programa de Pós-Graduação Rede Nordeste de Biotecnologia (RENORBIO). São Luis, MA, Brasil. |
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2023 |
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2023-05-26T15:59:10Z |
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2023-05-26T15:59:10Z |
| dc.date.issued.fl_str_mv |
2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
MUNIZ FILHO, Walbert Edson et al. Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model. Cancers, v. 15, 2544, p. 1 - 20, April 2023. |
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https://www.arca.fiocruz.br/handle/icict/58747 |
| dc.identifier.issn.en_US.fl_str_mv |
2072-6694 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/cancers15092544 |
| identifier_str_mv |
MUNIZ FILHO, Walbert Edson et al. Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model. Cancers, v. 15, 2544, p. 1 - 20, April 2023. 2072-6694 10.3390/cancers15092544 |
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https://www.arca.fiocruz.br/handle/icict/58747 |
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eng |
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eng |
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openAccess |
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MDPI |
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MDPI |
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