Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses

Detalhes bibliográficos
Autor(a) principal: Chicaybam, Leonardo
Data de Publicação: 2014
Outros Autores: Bonamino, Martin Hernan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35649
Resumo: 2020-09-18
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spelling Chicaybam, LeonardoBonamino, Martin Hernan2019-09-18T12:00:29Z2019-09-18T12:00:29Z2014CHICAYBAM, Leonardo; BONAMINO, Martin Hernan. Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses. International Reviews of Immunology, p. 1-15, 2014.0883-0185https://www.arca.fiocruz.br/handle/icict/3564910.3109/08830185.2014.9174121563-5244engInforma HealthcareMoving receptor redirected adoptive cell therapy toward fine tuning of antitumor responsesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-09-18Instituto Nacional de Câncer. Coordenação de Pesquisa. Programa de Carcinogênese Molecular. Rio de Janeiro, RJ, Brasil / Fundação Instituto Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Coordenação de Pesquisa. Programa de Carcinogênese Molecular. Rio de Janeiro, RJ, Brasil.Adoptive cell transfer (ACT) is emerging as a powerful modality of cancer treatment. While ACT has proved able to induce massive clinical responses, genetic modification of T lymphocytes further improved clinical responses obtained. One of the major current limitations of ACT is the inability to discern healthy from malignant cells, leading to on target/off tumor responses that can limit its application. We here discuss some of the approaches currently under development and potential solutions to circumvent these limitations and extend this potentially curative therapy to different tumors by targeting a variety of antigens.Adoptive cell therapyCancerChimeric antigen receptorGene therapyImmunotherapyOff-targetTumor antigeninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/35649/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Chicaybam_Leonardo_etal__INI_2014.pdfve_Chicaybam_Leonardo_etal__INI_2014.pdfapplication/pdf346168https://www.arca.fiocruz.br/bitstream/icict/35649/2/ve_Chicaybam_Leonardo_etal__INI_2014.pdf70589b8a79f40f9cbdf3ddb70f33a8afMD52TEXTve_Chicaybam_Leonardo_etal__INI_2014.pdf.txtve_Chicaybam_Leonardo_etal__INI_2014.pdf.txtExtracted texttext/plain64038https://www.arca.fiocruz.br/bitstream/icict/35649/3/ve_Chicaybam_Leonardo_etal__INI_2014.pdf.txtc5c5d2297925324efc125160f52ea9e8MD53icict/356492021-03-24 16:32:36.388oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses
title Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses
spellingShingle Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses
Chicaybam, Leonardo
Adoptive cell therapy
Cancer
Chimeric antigen receptor
Gene therapy
Immunotherapy
Off-target
Tumor antigen
title_short Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses
title_full Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses
title_fullStr Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses
title_full_unstemmed Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses
title_sort Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses
author Chicaybam, Leonardo
author_facet Chicaybam, Leonardo
Bonamino, Martin Hernan
author_role author
author2 Bonamino, Martin Hernan
author2_role author
dc.contributor.author.fl_str_mv Chicaybam, Leonardo
Bonamino, Martin Hernan
dc.subject.en.pt_BR.fl_str_mv Adoptive cell therapy
Cancer
Chimeric antigen receptor
Gene therapy
Immunotherapy
Off-target
Tumor antigen
topic Adoptive cell therapy
Cancer
Chimeric antigen receptor
Gene therapy
Immunotherapy
Off-target
Tumor antigen
description 2020-09-18
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2019-09-18T12:00:29Z
dc.date.available.fl_str_mv 2019-09-18T12:00:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHICAYBAM, Leonardo; BONAMINO, Martin Hernan. Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses. International Reviews of Immunology, p. 1-15, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35649
dc.identifier.issn.pt_BR.fl_str_mv 0883-0185
dc.identifier.doi.none.fl_str_mv 10.3109/08830185.2014.917412
dc.identifier.eissn.none.fl_str_mv 1563-5244
identifier_str_mv CHICAYBAM, Leonardo; BONAMINO, Martin Hernan. Moving receptor redirected adoptive cell therapy toward fine tuning of antitumor responses. International Reviews of Immunology, p. 1-15, 2014.
0883-0185
10.3109/08830185.2014.917412
1563-5244
url https://www.arca.fiocruz.br/handle/icict/35649
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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