Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study

Detalhes bibliográficos
Autor(a) principal: Bezerra, D. C.
Data de Publicação: 2011
Outros Autores: Sharrett, A. R., Matsushita, K., Gottesman, R. F., Shibata, D., Mosley Jr, T. H., Coresh, J., Szklo, M., Carvalho, M. S., Selvin, E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56796
Resumo: Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health, Baltimore / Oswaldo Cruz Foundation. National School of Public Health. Rio de Janeiro, RJ, Brazil.
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spelling Bezerra, D. C.Sharrett, A. R.Matsushita, K.Gottesman, R. F.Shibata, D.Mosley Jr, T. H.Coresh, J.Szklo, M.Carvalho, M. S.Selvin, E.2023-01-31T20:02:54Z2023-01-31T20:02:54Z2011BEZERRA, D. C. et al. Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study. Neurology, v. 78, n. 2, p. 102-108, 2012.0028-3878https://www.arca.fiocruz.br/handle/icict/5679610.1212/WNL.0b013e31823efc421526-632XengAmerican Academy of NeurologyRisk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health, Baltimore / Oswaldo Cruz Foundation. National School of Public Health. Rio de Janeiro, RJ, Brazil.Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health, Baltimore.Department of Neurology Johns Hopkins University School of Medicine, Baltimore.Department of Radiology. University of Washington Medical Center. Seattle and Department of Medicine Geriatrics. University of Mississippi Medical Center, Jackson.Department of Radiology. University of Washington Medical Center. Seattle and Department of Medicine Geriatrics. University of Mississippi Medical Center, Jackson.Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health, Baltimore.Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health, Baltimore.Oswaldo Cruz Foundation. National School of Public Health. Rio de Janeiro, RJ, Brazil.Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health, Baltimore.University of Mississippi Medical Center Jackson. Mississippi, EUA.Objective: Lacunar infarctions are mainly due to 2 microvascular pathologies: lipohyalinosis and microatheroma. Little is known about risk factor differences for these subtypes. We hypothesized that diabetes and glycated hemoglobin (HbA(1)c) would be related preferentially to the lipohyalinotic subtype. Methods: We performed a cross-section analysis of the brain MRI data from 1,827 participants in the Atherosclerosis Risk in Communities study. We divided subcortical lesions ≤ 20 mm in diameter into those ≤ 7 mm (of probable lipohyalinotic etiology) and 8-20 mm (probably due to microatheroma) and used Poisson regression to investigate associations with the number of each type of lesion. Unlike previous studies, we also fitted a model involving lesions <3 mm. Results: Age (prevalence ratio [PR] 1.11 per year; 95% confidence interval [CI] 1.08-1.14), black ethnicity (vs white, PR 1.66; 95% CI 1.27-2.16), hypertension (PR 2.12; 95% CI 1.61-2.79), diabetes (PR 1.42; 95% CI 1.08-1.87), and ever-smoking (PR 1.34; 95% CI 1.04-1.74) were significantly associated with lesions ≤ 7 mm. Findings were similar for lesions <3 mm. HbA(1)c, substituted for diabetes, was also associated with smaller lesions. Significantly associated with 8-20 mm lesions were age (PR 1.14; 95% CI 1.09-1.20), hypertension (PR 1.79; 95% CI 1.14-2.83), ever-smoking (PR 2.66; 95% CI 1.63-4.34), and low-density lipoprotein (LDL) cholesterol (PR 1.27 per SD; 95% CI 1.06-1.52). When we analyzed only participants with lesions, history of smoking (PR 1.99; 95% CI 1.23-3.20) and LDL (PR 1.33 per SD; 95% CI 1.08-1.65) were associated with lesions 8-20 mm. Conclusions: Smaller lacunes (even those <3 mm) were associated with diabetes and HbA(1)c, and larger lacunes associated with LDL cholesterol, differences which support long-held theories relating to their underlying pathology. The findings may contribute to broader understanding of cerebral microvascular disease.AtherosclerosisRisk Factorsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/56796/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALRiskFactors.pdfapplication/pdf583660https://www.arca.fiocruz.br/bitstream/icict/56796/2/RiskFactors.pdf5c4590ca9aab2a4586fe738129cd1425MD52icict/567962023-04-11 11:33:47.371oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-11T14:33:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study
title Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study
spellingShingle Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study
Bezerra, D. C.
Atherosclerosis
Risk Factors
title_short Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study
title_full Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study
title_fullStr Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study
title_full_unstemmed Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study
title_sort Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study
author Bezerra, D. C.
author_facet Bezerra, D. C.
Sharrett, A. R.
Matsushita, K.
Gottesman, R. F.
Shibata, D.
Mosley Jr, T. H.
Coresh, J.
Szklo, M.
Carvalho, M. S.
Selvin, E.
author_role author
author2 Sharrett, A. R.
Matsushita, K.
Gottesman, R. F.
Shibata, D.
Mosley Jr, T. H.
Coresh, J.
Szklo, M.
Carvalho, M. S.
Selvin, E.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bezerra, D. C.
Sharrett, A. R.
Matsushita, K.
Gottesman, R. F.
Shibata, D.
Mosley Jr, T. H.
Coresh, J.
Szklo, M.
Carvalho, M. S.
Selvin, E.
dc.subject.en.en_US.fl_str_mv Atherosclerosis
Risk Factors
topic Atherosclerosis
Risk Factors
description Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health, Baltimore / Oswaldo Cruz Foundation. National School of Public Health. Rio de Janeiro, RJ, Brazil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2023-01-31T20:02:54Z
dc.date.available.fl_str_mv 2023-01-31T20:02:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BEZERRA, D. C. et al. Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study. Neurology, v. 78, n. 2, p. 102-108, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56796
dc.identifier.issn.en_US.fl_str_mv 0028-3878
dc.identifier.doi.none.fl_str_mv 10.1212/WNL.0b013e31823efc42
dc.identifier.eissn.none.fl_str_mv 1526-632X
identifier_str_mv BEZERRA, D. C. et al. Risk factors for lacune subtypes in the Atherosclerosis Risk in Communities (ARIC) Study. Neurology, v. 78, n. 2, p. 102-108, 2012.
0028-3878
10.1212/WNL.0b013e31823efc42
1526-632X
url https://www.arca.fiocruz.br/handle/icict/56796
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Academy of Neurology
publisher.none.fl_str_mv American Academy of Neurology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56796/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56796/2/RiskFactors.pdf
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