Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50615 |
Resumo: | Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. |
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Dejnirattisai, WanwisaHuo, JiandongZhou, DamingZahradník, JiříSupasa, PiyadaLiu, ChangDuyvesteyn, Helen M. E.Ginn, Helen M.Mentzer, Alexander J.Tuekprakhon, AekkachaiNutalai, RungtiwaWang, BeibeiDijokaite, AisteKhan, SumanAvinoam, OriBahar, MohammadSkelly, DonalAdele, SandraJohnson, Sile AnnAmini, AliRitter, ThomasMason, ChrisDold, ChristinaPan, DanielAssadi, SaraBellass, AdamOmo-Dare, NikkiKoeckerling, DavidFlaxman, AmyJenkin, DanielAley, Parvinder K.Voysey, MerrynClemens, Sue Ann CostaNaveca, Felipe GomesNascimento, ValdineteNascimento, FernandaCosta, Cristiano Fernandes daResende, Paola CristinaPauvolid-Correa, AlexSiqueira, Marilda Agudo Mendonça Teixeira deBaillie, VickySerafin, NataliDitse, ZaneleSilva, Kelly daMadhi, ShabirNunes, Marta C.Malik, TariqOpenshaw, Peter J. M.Baillie, J. KennethSemple, Malcolm G.Townsend, Alain R.Huang, Kuan-Ying A.Tan, Tiong KitCarroll, Miles W.Klenerman, PaulBarnes, EleanorDunachie, Susanna J.Constantinides, BedeWebster, HermioneCrook, DerrickPollard, Andrew J.Lambe, TeresaPaterson, Neil G.Williams, Mark A.Hall, David R.Fry, Elizabeth E.Mongkolsapaya, JuthathipRen, JingshanSchreiber, GideonStuart, David I.Screaton, Gavin R.2022-01-04T19:35:13Z2022-01-04T19:35:13Z2021DEJNIRATTISAI, Wanwisa et al. Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. bioRxiv, p. 1-64, Dec. 2021.https://www.arca.fiocruz.br/handle/icict/5061510.1101/2021.12.03.471045engbioRxiv preprintOmicronSARS CoV-2África do SulMutaçõesOmicronSARS CoV-2Southern AfricaMutations in Spike (S)Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responsesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK / Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK / . Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK / Oxford University Hospitals NHS Foundation Trust, Oxford, UK.Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.Oxford University Hospitals NHS Foundation Trust, Oxford, UK / Peter Medawar Building for Pathogen Research, Oxford, UK / Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.Oxford University Hospitals NHS Foundation Trust, Oxford, UK.Oxford University Hospitals NHS Foundation Trust, Oxford, UK.NIHR Oxford Biomedical Research Centre, Oxford, UK / Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust / Department of Respiratory Sciences, University of Leicester.Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust.Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust.Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust.Medical Sciences Division, University of Oxford.Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.Institute of Global Health, University of Siena, Siena, Brazil; Department of Paediatrics, University of Oxford, Oxford, UK.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.Fundação de Vigilância em Saúde do Amazonas. Manaus, AM, Brasil,Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Laboratorio de Vírus respiratórios. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Laboratorio de Vírus respiratórios. Rio de Janeiro, RJ, Brasil / Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Laboratorio de Vírus respiratórios. Rio de Janeiro, RJ, Brasil.South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa / Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa / Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa / Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa / Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa / Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa / Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.National Heart & Lung Institute, Imperial College London.Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, UK.NIHR Health Protection Research Unit, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK / MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK.Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK..Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK / National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.Oxford University Hospitals NHS Foundation Trust, Oxford, UK / Peter Medawar Building for Pathogen Research, Oxford, UK / Translational Gastroenterology Unit, University of Oxford, Oxford, UK / NIHR Oxford Biomedical Research Centre, Oxford, UK.Oxford University Hospitals NHS Foundation Trust, Oxford, UK / Peter Medawar Building for Pathogen Research, Oxford, UK / Centre For Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK / Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand, Department of Medicine, University of Oxford, Oxford, UK.Nuffield Department of Medicine, University of Oxford, Oxford, UK.Nuffield Department of Medicine, University of Oxford, Oxford, UK.Nuffield Department of Medicine, University of Oxford, Oxford, UK.NIHR Oxford Biomedical Research Centre, Oxford, UK / Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK / Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.OPTIC consortium&ISARIC4C consortium$Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK / Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK / Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand.Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, .Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK / Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK / Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK / Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, UK.Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK / Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.On the 24th November 2021 the sequence of a new SARS CoV-2 viral isolate spreading rapidly in Southern Africa was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titres of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic as well as Alpha, Beta, Gamma, Delta are substantially reduced or fail to neutralize. Titres against Omicron are boosted by third vaccine doses and are high in cases both vaccinated and infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of a large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses, combining mutations conferring tight binding to ACE2 to unleash evolution driven by immune escape, leading to a large number of mutations in the ACE2 binding site which rebalance receptor affinity to that of early pandemic viruses.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83134https://www.arca.fiocruz.br/bitstream/icict/50615/1/license.txt0ab46789d568c4ba27c7b5d29a9fe9c4MD51ORIGINALDejnirattisai_Wanwisa_etal_IOC_COVID-19_2021_PREPRINT.pdfDejnirattisai_Wanwisa_etal_IOC_COVID-19_2021_PREPRINT.pdfapplication/pdf11884208https://www.arca.fiocruz.br/bitstream/icict/50615/2/Dejnirattisai_Wanwisa_etal_IOC_COVID-19_2021_PREPRINT.pdf1d414971dc4e77cb58226f44f76b8be6MD52icict/506152022-03-23 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| dc.title.pt_BR.fl_str_mv |
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses |
| title |
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses |
| spellingShingle |
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses Dejnirattisai, Wanwisa Omicron SARS CoV-2 África do Sul Mutações Omicron SARS CoV-2 Southern Africa Mutations in Spike (S) |
| title_short |
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses |
| title_full |
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses |
| title_fullStr |
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses |
| title_full_unstemmed |
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses |
| title_sort |
Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses |
| author |
Dejnirattisai, Wanwisa |
| author_facet |
Dejnirattisai, Wanwisa Huo, Jiandong Zhou, Daming Zahradník, Jiří Supasa, Piyada Liu, Chang Duyvesteyn, Helen M. E. Ginn, Helen M. Mentzer, Alexander J. Tuekprakhon, Aekkachai Nutalai, Rungtiwa Wang, Beibei Dijokaite, Aiste Khan, Suman Avinoam, Ori Bahar, Mohammad Skelly, Donal Adele, Sandra Johnson, Sile Ann Amini, Ali Ritter, Thomas Mason, Chris Dold, Christina Pan, Daniel Assadi, Sara Bellass, Adam Omo-Dare, Nikki Koeckerling, David Flaxman, Amy Jenkin, Daniel Aley, Parvinder K. Voysey, Merryn Clemens, Sue Ann Costa Naveca, Felipe Gomes Nascimento, Valdinete Nascimento, Fernanda Costa, Cristiano Fernandes da Resende, Paola Cristina Pauvolid-Correa, Alex Siqueira, Marilda Agudo Mendonça Teixeira de Baillie, Vicky Serafin, Natali Ditse, Zanele Silva, Kelly da Madhi, Shabir Nunes, Marta C. Malik, Tariq Openshaw, Peter J. M. Baillie, J. Kenneth Semple, Malcolm G. Townsend, Alain R. Huang, Kuan-Ying A. Tan, Tiong Kit Carroll, Miles W. Klenerman, Paul Barnes, Eleanor Dunachie, Susanna J. Constantinides, Bede Webster, Hermione Crook, Derrick Pollard, Andrew J. Lambe, Teresa Paterson, Neil G. Williams, Mark A. Hall, David R. Fry, Elizabeth E. Mongkolsapaya, Juthathip Ren, Jingshan Schreiber, Gideon Stuart, David I. Screaton, Gavin R. |
| author_role |
author |
| author2 |
Huo, Jiandong Zhou, Daming Zahradník, Jiří Supasa, Piyada Liu, Chang Duyvesteyn, Helen M. E. Ginn, Helen M. Mentzer, Alexander J. Tuekprakhon, Aekkachai Nutalai, Rungtiwa Wang, Beibei Dijokaite, Aiste Khan, Suman Avinoam, Ori Bahar, Mohammad Skelly, Donal Adele, Sandra Johnson, Sile Ann Amini, Ali Ritter, Thomas Mason, Chris Dold, Christina Pan, Daniel Assadi, Sara Bellass, Adam Omo-Dare, Nikki Koeckerling, David Flaxman, Amy Jenkin, Daniel Aley, Parvinder K. Voysey, Merryn Clemens, Sue Ann Costa Naveca, Felipe Gomes Nascimento, Valdinete Nascimento, Fernanda Costa, Cristiano Fernandes da Resende, Paola Cristina Pauvolid-Correa, Alex Siqueira, Marilda Agudo Mendonça Teixeira de Baillie, Vicky Serafin, Natali Ditse, Zanele Silva, Kelly da Madhi, Shabir Nunes, Marta C. Malik, Tariq Openshaw, Peter J. M. Baillie, J. Kenneth Semple, Malcolm G. Townsend, Alain R. Huang, Kuan-Ying A. Tan, Tiong Kit Carroll, Miles W. Klenerman, Paul Barnes, Eleanor Dunachie, Susanna J. Constantinides, Bede Webster, Hermione Crook, Derrick Pollard, Andrew J. Lambe, Teresa Paterson, Neil G. Williams, Mark A. Hall, David R. Fry, Elizabeth E. Mongkolsapaya, Juthathip Ren, Jingshan Schreiber, Gideon Stuart, David I. Screaton, Gavin R. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Dejnirattisai, Wanwisa Huo, Jiandong Zhou, Daming Zahradník, Jiří Supasa, Piyada Liu, Chang Duyvesteyn, Helen M. E. Ginn, Helen M. Mentzer, Alexander J. Tuekprakhon, Aekkachai Nutalai, Rungtiwa Wang, Beibei Dijokaite, Aiste Khan, Suman Avinoam, Ori Bahar, Mohammad Skelly, Donal Adele, Sandra Johnson, Sile Ann Amini, Ali Ritter, Thomas Mason, Chris Dold, Christina Pan, Daniel Assadi, Sara Bellass, Adam Omo-Dare, Nikki Koeckerling, David Flaxman, Amy Jenkin, Daniel Aley, Parvinder K. Voysey, Merryn Clemens, Sue Ann Costa Naveca, Felipe Gomes Nascimento, Valdinete Nascimento, Fernanda Costa, Cristiano Fernandes da Resende, Paola Cristina Pauvolid-Correa, Alex Siqueira, Marilda Agudo Mendonça Teixeira de Baillie, Vicky Serafin, Natali Ditse, Zanele Silva, Kelly da Madhi, Shabir Nunes, Marta C. Malik, Tariq Openshaw, Peter J. M. Baillie, J. Kenneth Semple, Malcolm G. Townsend, Alain R. Huang, Kuan-Ying A. Tan, Tiong Kit Carroll, Miles W. Klenerman, Paul Barnes, Eleanor Dunachie, Susanna J. Constantinides, Bede Webster, Hermione Crook, Derrick Pollard, Andrew J. Lambe, Teresa Paterson, Neil G. Williams, Mark A. Hall, David R. Fry, Elizabeth E. Mongkolsapaya, Juthathip Ren, Jingshan Schreiber, Gideon Stuart, David I. Screaton, Gavin R. |
| dc.subject.other.pt_BR.fl_str_mv |
Omicron SARS CoV-2 África do Sul Mutações |
| topic |
Omicron SARS CoV-2 África do Sul Mutações Omicron SARS CoV-2 Southern Africa Mutations in Spike (S) |
| dc.subject.en.pt_BR.fl_str_mv |
Omicron SARS CoV-2 Southern Africa Mutations in Spike (S) |
| description |
Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. |
| publishDate |
2021 |
| dc.date.issued.fl_str_mv |
2021 |
| dc.date.accessioned.fl_str_mv |
2022-01-04T19:35:13Z |
| dc.date.available.fl_str_mv |
2022-01-04T19:35:13Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
DEJNIRATTISAI, Wanwisa et al. Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. bioRxiv, p. 1-64, Dec. 2021. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/50615 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1101/2021.12.03.471045 |
| identifier_str_mv |
DEJNIRATTISAI, Wanwisa et al. Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses. bioRxiv, p. 1-64, Dec. 2021. 10.1101/2021.12.03.471045 |
| url |
https://www.arca.fiocruz.br/handle/icict/50615 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
bioRxiv preprint |
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bioRxiv preprint |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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repositorio.arca@fiocruz.br |
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