Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23159 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. |
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Tuyama, MariAntônio, Jessica CorrêaSchlackman, JessicaMarsh, Jane W.Rebelo, Maria C.Cerqueira, Elaine O.Nehab, MárcioKegele, FabíolaCarmo, Getúlio F.Thielmann, Dominique C. A.Barroso, Paulo F.Harrison, Lee H.Barroso, David E.2017-11-14T12:54:13Z2017-11-14T12:54:13Z2017TUYAMA, Mary et al. Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 3, p. 196-202, Mar. 2017.0074-0276https://www.arca.fiocruz.br/handle/icict/2315910.1590/0074-027601603911678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzHaemophilus influenzaeMeningiteSorogrupoVacinaHaemophilus influenzaeMeningitisMLSTVaccineSerotypesInvasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brasil.University of Pittsburgh. School of Medicine and Graduate School of Public Health. Infectious Diseases Epidemiology Research Unit. Pittsburgh, PA, USA.University of Pittsburgh. School of Medicine and Graduate School of Public Health. Infectious Diseases Epidemiology Research Unit. Pittsburgh, PA, USA.Secretaria de Estado de Saúde do Rio de Janeiro. Assessoria de Meningites. Rio de Janeiro, RJ, Brasil.Secretaria de Estado de Saúde do Rio de Janeiro. Assessoria de Meningites. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.CientíficaLab. Rio de Janeiro, RJ, Brasil.CientíficaLab. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.University of Pittsburgh. School of Medicine and Graduate School of Public Health. Infectious Diseases Epidemiology Research Unit. Pittsburgh, PA, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brasil.BACKGROUND Haemophilus influenzae (Hi) serotype b (Hib) conjugate vaccine was incorporated into the infant immunisation schedule in Brazil in 1999, where Hib was one of the major etiologic sources of community-acquired bacterial meningitis. OBJECTIVES The purpose of this study is to describe the molecular epidemiology of invasive Hi disease in Rio de Janeiro state, Brazil, before and after vaccine introduction. METHODS Surveillance data from 1986 to 2014 were analysed. Hi isolates recovered from cerebrospinal fluid (CSF) or blood from 1993 to 2014 were serotyped by slide agglutination, genotyped by multilocus sequence typing (MLST), and the capsule type evaluation, differentiation of serologically non-typeable isolates, and characterisation of the capsule (cap) locus was done by polymerase chain reaction. Antimicrobial susceptibility testing was performed using E-test. FINDINGS From 1986 to 1999 and from 2000 to 2014, 2580 and 197 (42% without serotype information) confirmed cases were reported, respectively. The case fatality rate was 17% and did not correlate with the strain. Hib and b-variant isolates belonged to ST-6, whereas serotype a isolates belonged to the ST-23 clonal complex. Serotype a appeared to emerge during the 2000s. Non-encapsulated isolates were non-clonal and distinct from the encapsulated isolates. Ampicillin-resistant isolates were neither of serotype b or were non-encapsulated, and all of them were β-lactamase-positive but amoxicillin-clavulanic acid susceptible. MAIN CONCLUSIONS Although Hi meningitis became a relatively rare disease in Rio de Janeiro after the introduction of the Hib conjugate vaccine, the isolates recovered from patients have become more diverse. These results indicate the need to implement an enhanced surveillance system to continue monitoring the impact of the Hib conjugate vaccine.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23159/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmary_tuyama_etal_IOC_2017.pdfmary_tuyama_etal_IOC_2017.pdfapplication/pdf672622https://www.arca.fiocruz.br/bitstream/icict/23159/2/mary_tuyama_etal_IOC_2017.pdfa5d4059a8a891fbbed78401479f98d57MD52TEXTmary_tuyama_etal_IOC_2017.pdf.txtmary_tuyama_etal_IOC_2017.pdf.txtExtracted texttext/plain36758https://www.arca.fiocruz.br/bitstream/icict/23159/3/mary_tuyama_etal_IOC_2017.pdf.txt2e5204224d22ef21e52610101d2da26cMD53icict/231592019-07-22 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| dc.title.pt_BR.fl_str_mv |
Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil |
| title |
Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil |
| spellingShingle |
Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil Tuyama, Mari Haemophilus influenzae Meningite Sorogrupo Vacina Haemophilus influenzae Meningitis MLST Vaccine Serotypes |
| title_short |
Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil |
| title_full |
Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil |
| title_fullStr |
Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil |
| title_full_unstemmed |
Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil |
| title_sort |
Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil |
| author |
Tuyama, Mari |
| author_facet |
Tuyama, Mari Antônio, Jessica Corrêa Schlackman, Jessica Marsh, Jane W. Rebelo, Maria C. Cerqueira, Elaine O. Nehab, Márcio Kegele, Fabíola Carmo, Getúlio F. Thielmann, Dominique C. A. Barroso, Paulo F. Harrison, Lee H. Barroso, David E. |
| author_role |
author |
| author2 |
Antônio, Jessica Corrêa Schlackman, Jessica Marsh, Jane W. Rebelo, Maria C. Cerqueira, Elaine O. Nehab, Márcio Kegele, Fabíola Carmo, Getúlio F. Thielmann, Dominique C. A. Barroso, Paulo F. Harrison, Lee H. Barroso, David E. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Tuyama, Mari Antônio, Jessica Corrêa Schlackman, Jessica Marsh, Jane W. Rebelo, Maria C. Cerqueira, Elaine O. Nehab, Márcio Kegele, Fabíola Carmo, Getúlio F. Thielmann, Dominique C. A. Barroso, Paulo F. Harrison, Lee H. Barroso, David E. |
| dc.subject.other.pt_BR.fl_str_mv |
Haemophilus influenzae Meningite Sorogrupo Vacina |
| topic |
Haemophilus influenzae Meningite Sorogrupo Vacina Haemophilus influenzae Meningitis MLST Vaccine Serotypes |
| dc.subject.en.pt_BR.fl_str_mv |
Haemophilus influenzae Meningitis MLST Vaccine Serotypes |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Epidemiologia e Sistemática Molecular. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil. |
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2017 |
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2017-11-14T12:54:13Z |
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2017-11-14T12:54:13Z |
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2017 |
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TUYAMA, Mary et al. Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 3, p. 196-202, Mar. 2017. |
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https://www.arca.fiocruz.br/handle/icict/23159 |
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0074-0276 |
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10.1590/0074-02760160391 |
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1678-8060 |
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TUYAMA, Mary et al. Invasive Haemophilus influenzae disease in the vaccine era in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 112, n. 3, p. 196-202, Mar. 2017. 0074-0276 10.1590/0074-02760160391 1678-8060 |
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