Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposed
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44276 |
Resumo: | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. |
| id |
CRUZ_8dc80175847926f160ceb2e3903f3abd |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/44276 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Pizzatti, LucianaKawassaki, Aedra Carla BufaloFadel, BrunaNogueira, Fabio C. S.Evaristo, Joseph A. M.Woldmar, NicoleTeixeira, Géssica TuaniSilva, Janaína Carla daScandolara, Thalita BassoRech, DanielCandiotto, Luciano Pessôa ZanettiSilveira, Guilherme FerreiraPavanelli, Wander RogérioPanis, Carolina2020-10-30T18:32:02Z2020-10-30T18:32:02Z2020PIZZATTI, Luciana et al. Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in Breast Cancer women chronically exposed. Frontiers in Oncology. v. 10, n. 1698, p. 1-11, 2020.2234-943Xhttps://www.arca.fiocruz.br/handle/icict/4427610.3389/fonc.2020.016982234-943XporFrontiers MediaCâncer da MamaBreast NeoplasmsBreast CancerProteomicsTumor Necrosis Factor-alphaInterleukin-1betaSignal TransductionEstrogensPlaguicidasNeoplasias de la MamaProteómicaFactor de Necrosis Tumoral alfaInterleucina-1betaTransducción de SeñalEstrógenosPlaguicidasTumeurs du seinProtéomiqueFacteur de nécrose tumorale alphaInterleukine-1 bêtaTransduction du signalOestrogènesPesticidesNeoplasias da MamaProteômicaFator de Necrose Tumoral alfaInterleucina-1betaTransdução de SinaisEstrogêniosPraguicidasToxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposedinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil.Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil / Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil.Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil.Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Estadual de Londrina. Londrina, PR, Brasil.Universidade Estadual do Oeste do Paraná. Paraná, PR, Brasil / Universidade Estadual de Londrina. Londrina, PR, Brasil.Deleterious effects have been widely associated with chronic pesticide exposure, including cancer development. In spite of several known consequences that pesticides can trigger in the human body, few is known regarding its impact on breast câncer women that are chronically exposed to such substances during agricultural work lifelong. In this context, the present study performed a high-throughput toxicoproteomic study in association with a bioinformatics-based design to explore new putative processes and pathways deregulated by chronic pesticide exposure in breast câncer patients. To reach this goal, we analyzed comparatively non-depleted plasma samples from exposed (n = 130) and non-occupationally exposed (n = 112) women diagnosed with breast cancer by using a label-free proteomic tool. The list of proteins differentially expressed was explored by bioinformatics and the main pathways and processes further investigated. The toxicoproteomic study revealed that women exposed to pesticides exhibited mainly downregulated events, linked to immune response, coagulation and estrogen-mediated events in relation to the unexposed ones. Further investigation shown that the identified deregulated processes and pathways correlated with significant distinct levels tumor necrosis factor alpha and interleukin 1 beta in the blood, and specific clinicopathological characteristics pointed out by bioinformatics analysis as adipose-trophic levels, menopause and intratumoral clots formation. Altogether, these findings reinforce pesticides as downregulators of several biological process and highlight that these compounds can be linked to poor prognosis in breast câncer.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/44276/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfonc-10-0169.pdffonc-10-0169.pdfapplication/pdf1930274https://www.arca.fiocruz.br/bitstream/icict/44276/2/fonc-10-0169.pdf1b052ac71935d890d4bb8722206a6480MD52TEXTfonc-10-0169.pdf.txtfonc-10-0169.pdf.txtExtracted texttext/plain55861https://www.arca.fiocruz.br/bitstream/icict/44276/3/fonc-10-0169.pdf.txt3c5650e0d815e638d0b86db309d377dfMD53icict/442762020-11-04 15:02:04.567oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-11-04T18:02:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposed |
| title |
Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposed |
| spellingShingle |
Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposed Pizzatti, Luciana Câncer da Mama Breast Neoplasms Breast Cancer Proteomics Tumor Necrosis Factor-alpha Interleukin-1beta Signal Transduction Estrogens Plaguicidas Neoplasias de la Mama Proteómica Factor de Necrosis Tumoral alfa Interleucina-1beta Transducción de Señal Estrógenos Plaguicidas Tumeurs du sein Protéomique Facteur de nécrose tumorale alpha Interleukine-1 bêta Transduction du signal Oestrogènes Pesticides Neoplasias da Mama Proteômica Fator de Necrose Tumoral alfa Interleucina-1beta Transdução de Sinais Estrogênios Praguicidas |
| title_short |
Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposed |
| title_full |
Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposed |
| title_fullStr |
Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposed |
| title_full_unstemmed |
Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposed |
| title_sort |
Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in breast cancer women chronically exposed |
| author |
Pizzatti, Luciana |
| author_facet |
Pizzatti, Luciana Kawassaki, Aedra Carla Bufalo Fadel, Bruna Nogueira, Fabio C. S. Evaristo, Joseph A. M. Woldmar, Nicole Teixeira, Géssica Tuani Silva, Janaína Carla da Scandolara, Thalita Basso Rech, Daniel Candiotto, Luciano Pessôa Zanetti Silveira, Guilherme Ferreira Pavanelli, Wander Rogério Panis, Carolina |
| author_role |
author |
| author2 |
Kawassaki, Aedra Carla Bufalo Fadel, Bruna Nogueira, Fabio C. S. Evaristo, Joseph A. M. Woldmar, Nicole Teixeira, Géssica Tuani Silva, Janaína Carla da Scandolara, Thalita Basso Rech, Daniel Candiotto, Luciano Pessôa Zanetti Silveira, Guilherme Ferreira Pavanelli, Wander Rogério Panis, Carolina |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pizzatti, Luciana Kawassaki, Aedra Carla Bufalo Fadel, Bruna Nogueira, Fabio C. S. Evaristo, Joseph A. M. Woldmar, Nicole Teixeira, Géssica Tuani Silva, Janaína Carla da Scandolara, Thalita Basso Rech, Daniel Candiotto, Luciano Pessôa Zanetti Silveira, Guilherme Ferreira Pavanelli, Wander Rogério Panis, Carolina |
| dc.subject.other.pt_BR.fl_str_mv |
Câncer da Mama |
| topic |
Câncer da Mama Breast Neoplasms Breast Cancer Proteomics Tumor Necrosis Factor-alpha Interleukin-1beta Signal Transduction Estrogens Plaguicidas Neoplasias de la Mama Proteómica Factor de Necrosis Tumoral alfa Interleucina-1beta Transducción de Señal Estrógenos Plaguicidas Tumeurs du sein Protéomique Facteur de nécrose tumorale alpha Interleukine-1 bêta Transduction du signal Oestrogènes Pesticides Neoplasias da Mama Proteômica Fator de Necrose Tumoral alfa Interleucina-1beta Transdução de Sinais Estrogênios Praguicidas |
| dc.subject.en.pt_BR.fl_str_mv |
Breast Neoplasms Breast Cancer Proteomics Tumor Necrosis Factor-alpha Interleukin-1beta Signal Transduction Estrogens Plaguicidas |
| dc.subject.es.pt_BR.fl_str_mv |
Neoplasias de la Mama Proteómica Factor de Necrosis Tumoral alfa Interleucina-1beta Transducción de Señal Estrógenos Plaguicidas |
| dc.subject.fr.pt_BR.fl_str_mv |
Tumeurs du sein Protéomique Facteur de nécrose tumorale alpha Interleukine-1 bêta Transduction du signal Oestrogènes Pesticides |
| dc.subject.decs.pt_BR.fl_str_mv |
Neoplasias da Mama Proteômica Fator de Necrose Tumoral alfa Interleucina-1beta Transdução de Sinais Estrogênios Praguicidas |
| description |
Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2020 |
| dc.date.accessioned.fl_str_mv |
2020-10-30T18:32:02Z |
| dc.date.available.fl_str_mv |
2020-10-30T18:32:02Z |
| dc.date.issued.fl_str_mv |
2020 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
PIZZATTI, Luciana et al. Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in Breast Cancer women chronically exposed. Frontiers in Oncology. v. 10, n. 1698, p. 1-11, 2020. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/44276 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2234-943X |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.3389/fonc.2020.01698 |
| dc.identifier.eissn.none.fl_str_mv |
2234-943X |
| identifier_str_mv |
PIZZATTI, Luciana et al. Toxicoproteomics disclose pesticides as downregulators of TNF-a, IL-1b and estrogen receptor pathways in Breast Cancer women chronically exposed. Frontiers in Oncology. v. 10, n. 1698, p. 1-11, 2020. 2234-943X 10.3389/fonc.2020.01698 |
| url |
https://www.arca.fiocruz.br/handle/icict/44276 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/44276/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/44276/2/fonc-10-0169.pdf https://www.arca.fiocruz.br/bitstream/icict/44276/3/fonc-10-0169.pdf.txt |
| bitstream.checksum.fl_str_mv |
783568c2893d2e25a99990b126be1772 1b052ac71935d890d4bb8722206a6480 3c5650e0d815e638d0b86db309d377df |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009147929559040 |