Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47131 |
Resumo: | Fundação Oswaldo Cruz |
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Carvalho, Gustavo C. NascimentoCarvalho, Eduardo C. NascimentoRamos, Clara L.Vilas‑Boas, Ana LuisaCarvalho, Otávio A. MorenoVinhaes, Caian L.Duarte, Beatriz BarretoQueiroz, Artur Trancoso Lopo deAndrade, Bruno de BezerrilCarvalho, Cristiana M. Nascimento2021-05-11T17:40:30Z2021-05-11T17:40:30Z2021CARVALHO, Gustavo C. Nascimento et al. Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid. Scientific Reports, v. 11, n. 8474, p. 1-10, 19 Apr. 2021.2045-2322https://www.arca.fiocruz.br/handle/icict/4713110.1038/s41598-021-87895-4Fundação Oswaldo CruzMultinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, BrazilNational Institutes of Allergy and Infectious Diseases, National Institutes of Health [Grant Numbers U01AI115940, U01AI069923]Brazilian Council for Scientific and Technological Development (CNPq) [Grant Number 313466/2018-1]Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.José Silveira Foundation. Laboratório de Líquido Cefalorraquidiano. Salvador, BA, Brasil.Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil.Fundação Bahiana para Desenvolvimento das Ciências. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brasil / Universidade Salvador. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Faculdade de Medicina. Salvador, BA, Brasil / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Disease Research in Africa. Cape Town, South Africa / Vanderbilt University School of Medicine. Department of Medicine. Division of Infectious Diseases. Nashville, TN, USA.Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Departamento de Pediatria. Salvador, BA, Brasil.Not every neonate with congenital Zika virus (ZIKV) infection (CZI) is born with microcephaly. We compared inflammation mediators in CSF (cerebrospinal fluid obtained from lumbar puncture) between ZIKV‑exposed neonates with/without microcephaly (cases) and controls. In Brazil, in the same laboratory, we identified 14 ZIKV‑exposed neonates during the ZIKV epidemic (2015–2016), 7(50%) with and 7(50%) without microcephaly, without any other congenital infection, and 14 neonates (2017–2018) eligible to be controls and to match cases. 29 inflammation mediators were measured using Luminex immunoassay and multidimensional analyses were employed. Neonates with ZIKV‑associated microcephaly presented substantially higher degree of inflammatory perturbation, associated with uncoupled inflammatory response and decreased correlations between concentrations of inflammatory biomarkers. The groups of microcephalic and non‑microcephalic ZIKV‑exposed neonates were distinguished from the control group (area under curve [AUC] = 1; P < 0.0001). Between controls and those non‑microcephalic exposed to ZIKV, IL‑1β, IL‑3, IL‑4, IL‑7 and EOTAXIN were the top CSF markers. By comparing the microcephalic cases with controls, the top discriminant scores were for IL‑1β, IL‑3, EOTAXIN and IL‑12p70. The degree of inflammatory imbalance may be associated with microcephaly in CZI and it may aid additional investigations in experimental pre‑clinical models testing immune modulators in preventing extensive damage of the Central Nervous System.engNature ResearchBiomarcadoresImunologiaZika virusMicrocefaliaRecém-nascidoInfecçõesMediadores da inflamaçãoBiomarkersImmunologyZika virusMicrocephalyNewbornInfectionInflammation mediatorsZika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluidinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/47131/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCarvalho. Gustavo C. Nascimento Zika....pdfCarvalho. Gustavo C. Nascimento Zika....pdfapplication/pdf2446869https://www.arca.fiocruz.br/bitstream/icict/47131/2/Carvalho.%20Gustavo%20C.%20Nascimento%20Zika....pdf19d9e7b4aa68b843b6d9efa9eb7fc6f7MD5241598_2021_87895_MOESM1_ESM.docx41598_2021_87895_MOESM1_ESM.docxSupplementary Information 1.application/vnd.openxmlformats-officedocument.wordprocessingml.document197738https://www.arca.fiocruz.br/bitstream/icict/47131/4/41598_2021_87895_MOESM1_ESM.docx00e5b94180968f8f61a6323cd409e6cfMD5441598_2021_87895_MOESM2_ESM.xls41598_2021_87895_MOESM2_ESM.xlsSupplementary Information 2.application/vnd.ms-excel43608https://www.arca.fiocruz.br/bitstream/icict/47131/5/41598_2021_87895_MOESM2_ESM.xlsa0b4c30fe0437078bfba71dc21fc692fMD55TEXTCarvalho. Gustavo C. Nascimento Zika....pdf.txtCarvalho. Gustavo C. Nascimento Zika....pdf.txtExtracted texttext/plain50026https://www.arca.fiocruz.br/bitstream/icict/47131/3/Carvalho.%20Gustavo%20C.%20Nascimento%20Zika....pdf.txta3dc8008ab996cde0b86caceb73110f6MD53icict/471312023-03-15 14:34:26.788oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en.fl_str_mv |
Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid |
| title |
Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid |
| spellingShingle |
Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid Carvalho, Gustavo C. Nascimento Biomarcadores Imunologia Zika virus Microcefalia Recém-nascido Infecções Mediadores da inflamação Biomarkers Immunology Zika virus Microcephaly Newborn Infection Inflammation mediators |
| title_short |
Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid |
| title_full |
Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid |
| title_fullStr |
Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid |
| title_full_unstemmed |
Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid |
| title_sort |
Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid |
| author |
Carvalho, Gustavo C. Nascimento |
| author_facet |
Carvalho, Gustavo C. Nascimento Carvalho, Eduardo C. Nascimento Ramos, Clara L. Vilas‑Boas, Ana Luisa Carvalho, Otávio A. Moreno Vinhaes, Caian L. Duarte, Beatriz Barreto Queiroz, Artur Trancoso Lopo de Andrade, Bruno de Bezerril Carvalho, Cristiana M. Nascimento |
| author_role |
author |
| author2 |
Carvalho, Eduardo C. Nascimento Ramos, Clara L. Vilas‑Boas, Ana Luisa Carvalho, Otávio A. Moreno Vinhaes, Caian L. Duarte, Beatriz Barreto Queiroz, Artur Trancoso Lopo de Andrade, Bruno de Bezerril Carvalho, Cristiana M. Nascimento |
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author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Gustavo C. Nascimento Carvalho, Eduardo C. Nascimento Ramos, Clara L. Vilas‑Boas, Ana Luisa Carvalho, Otávio A. Moreno Vinhaes, Caian L. Duarte, Beatriz Barreto Queiroz, Artur Trancoso Lopo de Andrade, Bruno de Bezerril Carvalho, Cristiana M. Nascimento |
| dc.subject.other.pt_BR.fl_str_mv |
Biomarcadores Imunologia Zika virus Microcefalia Recém-nascido Infecções Mediadores da inflamação |
| topic |
Biomarcadores Imunologia Zika virus Microcefalia Recém-nascido Infecções Mediadores da inflamação Biomarkers Immunology Zika virus Microcephaly Newborn Infection Inflammation mediators |
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Biomarkers Immunology Zika virus Microcephaly Newborn Infection Inflammation mediators |
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Fundação Oswaldo Cruz |
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2021 |
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2021-05-11T17:40:30Z |
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2021-05-11T17:40:30Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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CARVALHO, Gustavo C. Nascimento et al. Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid. Scientific Reports, v. 11, n. 8474, p. 1-10, 19 Apr. 2021. |
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https://www.arca.fiocruz.br/handle/icict/47131 |
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2045-2322 |
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10.1038/s41598-021-87895-4 |
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CARVALHO, Gustavo C. Nascimento et al. Zika‑exposed microcephalic neonates exhibit higher degree of inflammatory imbalance in cerebrospinal fluid. Scientific Reports, v. 11, n. 8474, p. 1-10, 19 Apr. 2021. 2045-2322 10.1038/s41598-021-87895-4 |
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Nature Research |
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Nature Research |
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