Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50193 |
Resumo: | aSecretaria Municipal de Sa ude de Salvador, Salvador, Brazil bInstituto Gon¸calo Moniz, Funda¸c~ao Oswaldo Cruz, Salvador, Brazil cSecretaria de Sa ude do Estado da Bahia, Salvador, Brazil dCentro de Estudos do Mar, Universidade Federal do Paran a, Pontal do Paran a, Brazil eInstituto Federal de Santa Catarina, Campus Itajaí, Itajaí, Brazil fFaculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil |
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Cardoso, Cristiane WanderleySilva, Monaise Madalena Oliveira eBandeira, Antônio CarlosSilva, Renan BispoPrates, Ana Paula Pitanga BarbudaSoares, Enio SilvaSilva, Jose Jorge MorenoSouza, Lazaro Jose Rodrigues deSouza, Mirela Maisa da SilvaMuhana, Marcela AlmeidaPires, Rosildete Silva SantosAraujo Neto, Jose FernandoSantos, Manuela Sampaio SouzaMafra Junior, Luiz LaurenoAlves, Thiago PereiraSchramm, Mathias AlbertoRibeiro, Guilherme Sousa2021-12-07T11:47:39Z2021-12-07T11:47:39Z2021CARDOSO, Cristiane Wanderley et al. Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance. The Lancet, 2021.0140-6736https://www.arca.fiocruz.br/handle/icict/5019310.1016/j. lana.2021.100092aSecretaria Municipal de Sa ude de Salvador, Salvador, Brazil bInstituto Gon¸calo Moniz, Funda¸c~ao Oswaldo Cruz, Salvador, Brazil cSecretaria de Sa ude do Estado da Bahia, Salvador, Brazil dCentro de Estudos do Mar, Universidade Federal do Paran a, Pontal do Paran a, Brazil eInstituto Federal de Santa Catarina, Campus Itajaí, Itajaí, Brazil fFaculdade de Medicina, Universidade Federal da Bahia, Salvador, BrazilBrazilian Ministry of Health for providing fish analysis, and the Central Laboratory of Bahia (LACEN, Salvador, Brazil), Oswaldo Cruz Foundation (FIOCRUZ, Salvador, Brazil), Adolf Lutz Institute (S~ao Paulo, Brazil), Federal University Institute of ABC (Santo Andr e, Brazil), Federal Institute of Santa Catarina (Itaja ı, Brazil), and Food and Drugs Administration (FDA, Alabama, USA) for all laboratory analysis. We also thank the health professionals of Salvador and all patients for providing important information during our epidemiological investigations. This study was supported by the Centre for Strategic Information and Health Surveillance (CIEVS), Secretary of Health of Salvador; the Oswaldo Cruz Foundation; and the Federal University of Bahia. Guilherme Ribeiro receives a research scholarship from Brazilian National Council for Scientific and Technological Development (CNPq)."Múltipla ver em Notas"Background From late 2016 to early 2021, cases of Haff disease, a rare cause of rhabdomyolysis, possibly due to poisoning by palytoxin-like compounds in seafood, were detected in Salvador, Brazil. Surveillance was established to detect additional cases aiming at describing the clinical characteristics of the cases, identifying associated factors, estimating disease attack rate, and investigating the presence of biotoxins and trace metals in selected fish specimens obtained from cases. Method Between December/2016-January/2021, surveillance investigated Haff disease suspected cases, and obtained clinical and fish samples to test. Findings Of 65 cases investigated during the 2016-2017 outbreak, 43 (66%) had high creatine phosphokinase (CPK) levels. Among those with laboratory-confirmed rhabdomyolysis, 38 (88%) were hospitalized, 11 (26%) required intensive care, and three (7%) dialysis. Ingestion of marine fish 24h before disease onset was reported by 74% of the cases with elevated CPK and by 41% of those without CPK measurement (P=0¢02). Attack rate for individuals who ate fish related to the outbreak was 55%. Following this outbreak, surveillance identified 12 suspected cases between 2017-2019, and a second outbreak in 2020-2021, with 16 laboratory-confirmed rhabdomyolysis patients (five required intensive care; one died). No traces of ciguatoxins and metals were detected in fish specimens obtained in 2016, found to be Seriola rivoliana. Some fish samples from 2020 were screened for palytoxin (PlTX)-like compounds and contained detectable levels of molecule fragments characteristics of isobaric PlTX, ovatoxin-a (OVTX-a), OVTX-b and OVTX-d. Interpretation These findings support the hypothesis that compounds related to PlTX accumulated in marine fish may be the toxic agent causing the disease. Haff disease is a life-threatening condition, requiring clinical suspicion for patients with sudden-onset myalgia following fish ingestion. Suspected cases should be reported to health authorities for investigation.engElsevierRabdomióliseDoenças Transmitidas por AlimentosSaúde públicaSaúde globalSurto da doençaVigilânciaEpidemiologiaRhabdomyolysisHaff diseaseFoodborne diseasePalytoxinPublic healthGlobal healthOutbreakSurveillanceEpidemiologyHaff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillanceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50193/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCardoso, Cristiane Wanderley Haff disease....pdfCardoso, Cristiane Wanderley Haff 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Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance |
| title |
Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance |
| spellingShingle |
Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance Cardoso, Cristiane Wanderley Rabdomiólise Doenças Transmitidas por Alimentos Saúde pública Saúde global Surto da doença Vigilância Epidemiologia Rhabdomyolysis Haff disease Foodborne disease Palytoxin Public health Global health Outbreak Surveillance Epidemiology |
| title_short |
Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance |
| title_full |
Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance |
| title_fullStr |
Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance |
| title_full_unstemmed |
Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance |
| title_sort |
Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance |
| author |
Cardoso, Cristiane Wanderley |
| author_facet |
Cardoso, Cristiane Wanderley Silva, Monaise Madalena Oliveira e Bandeira, Antônio Carlos Silva, Renan Bispo Prates, Ana Paula Pitanga Barbuda Soares, Enio Silva Silva, Jose Jorge Moreno Souza, Lazaro Jose Rodrigues de Souza, Mirela Maisa da Silva Muhana, Marcela Almeida Pires, Rosildete Silva Santos Araujo Neto, Jose Fernando Santos, Manuela Sampaio Souza Mafra Junior, Luiz Laureno Alves, Thiago Pereira Schramm, Mathias Alberto Ribeiro, Guilherme Sousa |
| author_role |
author |
| author2 |
Silva, Monaise Madalena Oliveira e Bandeira, Antônio Carlos Silva, Renan Bispo Prates, Ana Paula Pitanga Barbuda Soares, Enio Silva Silva, Jose Jorge Moreno Souza, Lazaro Jose Rodrigues de Souza, Mirela Maisa da Silva Muhana, Marcela Almeida Pires, Rosildete Silva Santos Araujo Neto, Jose Fernando Santos, Manuela Sampaio Souza Mafra Junior, Luiz Laureno Alves, Thiago Pereira Schramm, Mathias Alberto Ribeiro, Guilherme Sousa |
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author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cardoso, Cristiane Wanderley Silva, Monaise Madalena Oliveira e Bandeira, Antônio Carlos Silva, Renan Bispo Prates, Ana Paula Pitanga Barbuda Soares, Enio Silva Silva, Jose Jorge Moreno Souza, Lazaro Jose Rodrigues de Souza, Mirela Maisa da Silva Muhana, Marcela Almeida Pires, Rosildete Silva Santos Araujo Neto, Jose Fernando Santos, Manuela Sampaio Souza Mafra Junior, Luiz Laureno Alves, Thiago Pereira Schramm, Mathias Alberto Ribeiro, Guilherme Sousa |
| dc.subject.other.pt_BR.fl_str_mv |
Rabdomiólise Doenças Transmitidas por Alimentos Saúde pública Saúde global Surto da doença Vigilância Epidemiologia |
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Rabdomiólise Doenças Transmitidas por Alimentos Saúde pública Saúde global Surto da doença Vigilância Epidemiologia Rhabdomyolysis Haff disease Foodborne disease Palytoxin Public health Global health Outbreak Surveillance Epidemiology |
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Rhabdomyolysis Haff disease Foodborne disease Palytoxin Public health Global health Outbreak Surveillance Epidemiology |
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aSecretaria Municipal de Sa ude de Salvador, Salvador, Brazil bInstituto Gon¸calo Moniz, Funda¸c~ao Oswaldo Cruz, Salvador, Brazil cSecretaria de Sa ude do Estado da Bahia, Salvador, Brazil dCentro de Estudos do Mar, Universidade Federal do Paran a, Pontal do Paran a, Brazil eInstituto Federal de Santa Catarina, Campus Itajaí, Itajaí, Brazil fFaculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil |
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2021 |
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2021-12-07T11:47:39Z |
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2021-12-07T11:47:39Z |
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2021 |
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CARDOSO, Cristiane Wanderley et al. Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance. The Lancet, 2021. |
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https://www.arca.fiocruz.br/handle/icict/50193 |
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0140-6736 |
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10.1016/j. lana.2021.100092 |
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CARDOSO, Cristiane Wanderley et al. Haff Disease in Salvador, Brazil, 2016-2021: Attack rate and detection of toxin in fish samples collected during outbreaks and disease surveillance. The Lancet, 2021. 0140-6736 10.1016/j. lana.2021.100092 |
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