Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2004 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/3272 |
Resumo: | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
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Silva, Luciana Menezes daOliveira, Sheilla Andrade deSantos, Ricardo Ribeiro dosAndrade, Zilton de AraújoSoares, Milena Botelho Pereira2011-10-28T17:30:24Z2011-10-28T17:30:24Z2004SILVA, L.M. et al. Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease. Acta Tropica, v. 91, n. 2, p. 189-196, jul. 2004.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/3272doi:10.1016/j.actatropica.2004.05.008engComparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.BACKGROUND: Schistosoma mansoni-infected mice tend to present with either one of two different hepatic pathological patterns during chronic infection: periportal fibrosis (PF) with portal concentration of periovular granulomas and fibrosis or isolated granulomas (IG), with scattered periovular granulomas within the liver. These are models for the two clinical presentations of schistosomiasis, the severe hepatosplenic and the mild intestinal forms. In the present work, we examined the relationship between the development of these histopathological aspects and immunological markers in S. mansoni-infected mice. Although BALB/c mice with PF and IG had similar egg numbers in the liver, PF mice had higher liver collagen contents than mice with IG. Cultured spleen cells from mice with PF and IG had similar proliferation 20 and 40 weeks after S. mansoni infection upon stimulation with parasite egg antigen (SEA) or mitogen (Con A). Production of IL-4 upon SEA stimulation was higher in cell cultures from mice with PF, whereas IL-5 and IFN-gamma levels were not statistically different between PF and IG groups. Mice with IG had similar serum concentrations of total IgE and anti-SEA IgG1, IgG2a, IgG2b and IgG3 compared to sera from PF mice. Levels of IgG1 and IgG2a antibodies were the highest and the lowest detected, respectively. In conclusion, isogenic BALB/c mice infected with S. mansoni that develop periportal fibrosis or isolated granulomas have similar immunological patterns despite the two pathologic forms of schistosomal liver fibrosis.Schistosoma mansoniImmune responseLiver fibrosisIsogenic miceAnimaisAnticorpos Anti-HelmínticosDoença CrônicaColágenoCitocinasELISAGranulomaHistocitoquímicaCirrose HepáticaAtivação LinfocíticaMasculinoCamundongosCamundongos Endogâmicos BALB CSchistosoma mansoniEsquistossomose mansoniBaçoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSilva LM Comparison of immune responses....pdfSilva LM Comparison of immune responses....pdfapplication/pdf128693https://www.arca.fiocruz.br/bitstream/icict/3272/1/Silva%20LM%20Comparison%20of%20immune%20responses....pdfef7e31b5bd21ae4c5421482328dee2b4MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3272/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTSilva LM Comparison of immune responses....pdf.txtSilva LM Comparison of immune responses....pdf.txtExtracted texttext/plain28617https://www.arca.fiocruz.br/bitstream/icict/3272/5/Silva%20LM%20Comparison%20of%20immune%20responses....pdf.txt9ab2e3935efff266068703ad6f92019bMD55THUMBNAILSilva LM Comparison of immune responses....pdf.jpgSilva LM Comparison of immune responses....pdf.jpgGenerated Thumbnailimage/jpeg1207https://www.arca.fiocruz.br/bitstream/icict/3272/4/Silva%20LM%20Comparison%20of%20immune%20responses....pdf.jpg4f2026404fd81f331eae8a05a2c99d57MD54icict/32722023-03-15 14:32:56.039oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease |
| title |
Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease |
| spellingShingle |
Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease Silva, Luciana Menezes da Schistosoma mansoni Immune response Liver fibrosis Isogenic mice Animais Anticorpos Anti-Helmínticos Doença Crônica Colágeno Citocinas ELISA Granuloma Histocitoquímica Cirrose Hepática Ativação Linfocítica Masculino Camundongos Camundongos Endogâmicos BALB C Schistosoma mansoni Esquistossomose mansoni Baço |
| title_short |
Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease |
| title_full |
Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease |
| title_fullStr |
Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease |
| title_full_unstemmed |
Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease |
| title_sort |
Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease |
| author |
Silva, Luciana Menezes da |
| author_facet |
Silva, Luciana Menezes da Oliveira, Sheilla Andrade de Santos, Ricardo Ribeiro dos Andrade, Zilton de Araújo Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Oliveira, Sheilla Andrade de Santos, Ricardo Ribeiro dos Andrade, Zilton de Araújo Soares, Milena Botelho Pereira |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Luciana Menezes da Oliveira, Sheilla Andrade de Santos, Ricardo Ribeiro dos Andrade, Zilton de Araújo Soares, Milena Botelho Pereira |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosoma mansoni Immune response Liver fibrosis Isogenic mice |
| topic |
Schistosoma mansoni Immune response Liver fibrosis Isogenic mice Animais Anticorpos Anti-Helmínticos Doença Crônica Colágeno Citocinas ELISA Granuloma Histocitoquímica Cirrose Hepática Ativação Linfocítica Masculino Camundongos Camundongos Endogâmicos BALB C Schistosoma mansoni Esquistossomose mansoni Baço |
| dc.subject.decs.pt_BR.fl_str_mv |
Animais Anticorpos Anti-Helmínticos Doença Crônica Colágeno Citocinas ELISA Granuloma Histocitoquímica Cirrose Hepática Ativação Linfocítica Masculino Camundongos Camundongos Endogâmicos BALB C Schistosoma mansoni Esquistossomose mansoni Baço |
| description |
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
| publishDate |
2004 |
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2004 |
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2011-10-28T17:30:24Z |
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2011-10-28T17:30:24Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
SILVA, L.M. et al. Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease. Acta Tropica, v. 91, n. 2, p. 189-196, jul. 2004. |
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https://www.arca.fiocruz.br/handle/icict/3272 |
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0001-706X |
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doi:10.1016/j.actatropica.2004.05.008 |
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SILVA, L.M. et al. Comparison of immune responses of Schistosoma mansoni-infected mice with distinct chronic forms of the disease. Acta Tropica, v. 91, n. 2, p. 189-196, jul. 2004. 0001-706X doi:10.1016/j.actatropica.2004.05.008 |
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