Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.

Detalhes bibliográficos
Autor(a) principal: Nevoa, Jessica Coraiola
Data de Publicação: 2023
Outros Autores: Latorre-Estivalis, Jose Manuel, Pais, Fabiano Sviatopolk Mirsky, Marliére, Newmar Pinto, Fernandes, Gabriel da Rocha, Lorenzo, Marcelo Gustavo, Guarneri, Alessandra Aparecida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57392
Resumo: Vector Behaviour and Pathogen Interaction Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
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spelling Nevoa, Jessica CoraiolaLatorre-Estivalis, Jose ManuelPais, Fabiano Sviatopolk MirskyMarliére, Newmar PintoFernandes, Gabriel da RochaLorenzo, Marcelo GustavoGuarneri, Alessandra Aparecida2023-03-15T19:01:28Z2023-03-15T19:01:28Z2023NEVOA; Jessica Coraiola et al. Global characterization of gene expression in the brain of starved immature Rhodnius prolixus. PLoS One, v. 18, n. 3, e0282490, 2023. doi: 10.1371/journal.pone.0282490.1932-6203https://www.arca.fiocruz.br/handle/icict/57392engPublic Library of ScienceGlobal characterization of gene expression in the brain of starved immature Rhodnius prolixus.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVector Behaviour and Pathogen Interaction Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Laboratorio de Insectos Sociales. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Buenos Aires, Argentina.Bioinformatics Plataform. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Vector Behaviour and Pathogen Interaction Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Bioinformatics Plataform. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Vector Behaviour and Pathogen Interaction Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Vector Behaviour and Pathogen Interaction Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Background: Rhodnius prolixus is a vector of Chagas disease and has become a model organism to study physiology, behavior, and pathogen interaction. The publication of its genome allowed initiating a process of comparative characterization of the gene expression profiles of diverse organs exposed to varying conditions. Brain processes control the expression of behavior and, as such, mediate immediate adjustment to a changing environment, allowing organisms to maximize their chances to survive and reproduce. The expression of fundamental behavioral processes like feeding requires fine control in triatomines because they obtain their blood meals from potential predators. Therefore, the characterization of gene expression profiles of key components modulating behavior in brain processes, like those of neuropeptide precursors and their receptors, seems fundamental. Here we study global gene expression profiles in the brain of starved R. prolixus fifth instar nymphs by means of RNA sequencing (RNA-Seq). Results: The expression of neuromodulatory genes such as those of precursors of neuropeptides, neurohormones, and their receptors; as well as the enzymes involved in the biosynthesis and processing of neuropeptides and biogenic amines were fully characterized. Other important gene targets such as neurotransmitter receptors, nuclear receptors, clock genes, sensory receptors, and takeouts genes were identified and their gene expression analyzed. Conclusion: We propose that the set of neuromodulatory-related genes highly expressed in the brain of starved R. prolixus nymphs deserves functional characterization to allow the subsequent development of tools targeting them for bug control. As the brain is a complex structure that presents functionally specialized areas, future studies should focus on characterizing gene expression profiles in target areas, e.g. mushroom bodies, to complement our current knowledge.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57392/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGlobal characterization of gene expression.pdfGlobal characterization of gene expression.pdfapplication/pdf1746494https://www.arca.fiocruz.br/bitstream/icict/57392/2/Global%20characterization%20of%20gene%20expression.pdfa32b056cf95c6e11f6b9d330e5e45aa1MD52icict/573922023-03-15 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dc.title.en_US.fl_str_mv Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.
title Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.
spellingShingle Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.
Nevoa, Jessica Coraiola
title_short Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.
title_full Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.
title_fullStr Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.
title_full_unstemmed Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.
title_sort Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.
author Nevoa, Jessica Coraiola
author_facet Nevoa, Jessica Coraiola
Latorre-Estivalis, Jose Manuel
Pais, Fabiano Sviatopolk Mirsky
Marliére, Newmar Pinto
Fernandes, Gabriel da Rocha
Lorenzo, Marcelo Gustavo
Guarneri, Alessandra Aparecida
author_role author
author2 Latorre-Estivalis, Jose Manuel
Pais, Fabiano Sviatopolk Mirsky
Marliére, Newmar Pinto
Fernandes, Gabriel da Rocha
Lorenzo, Marcelo Gustavo
Guarneri, Alessandra Aparecida
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nevoa, Jessica Coraiola
Latorre-Estivalis, Jose Manuel
Pais, Fabiano Sviatopolk Mirsky
Marliére, Newmar Pinto
Fernandes, Gabriel da Rocha
Lorenzo, Marcelo Gustavo
Guarneri, Alessandra Aparecida
description Vector Behaviour and Pathogen Interaction Group. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-15T19:01:28Z
dc.date.available.fl_str_mv 2023-03-15T19:01:28Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NEVOA; Jessica Coraiola et al. Global characterization of gene expression in the brain of starved immature Rhodnius prolixus. PLoS One, v. 18, n. 3, e0282490, 2023. doi: 10.1371/journal.pone.0282490.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57392
dc.identifier.issn.en_US.fl_str_mv 1932-6203
identifier_str_mv NEVOA; Jessica Coraiola et al. Global characterization of gene expression in the brain of starved immature Rhodnius prolixus. PLoS One, v. 18, n. 3, e0282490, 2023. doi: 10.1371/journal.pone.0282490.
1932-6203
url https://www.arca.fiocruz.br/handle/icict/57392
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57392/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57392/2/Global%20characterization%20of%20gene%20expression.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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