Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/22954 |
Resumo: | “Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ)” |
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Ferreira, Júnia Raquel DutraAleluia, Milena MagalhãesFigueiredo, Camylla Vilas BoasVieira, Larissa Castro de LimaSantiago, Rayra PereiraGuarda, Caroline Conceição daBarbosa, Cynara GomesOliveira, Ricardo RiccioAdorno, Elisângela VitóriaGonçalves, Marilda de Souza2017-10-25T12:19:38Z2017-10-25T12:19:38Z2017FERREIRA, J. R. D. et al. Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives. Frontiers in Endocrinology, v. 8, sept. 2017.1664-2392https://www.arca.fiocruz.br/handle/icict/2295410.3389/fendo.2017.00256“Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ)”Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Salvador, BA, BrasilCombined oral contraceptive (COC) use has been associated with an unfavorable impact on carbohydrate and lipid metabolism in diverse populations of normal weight and obese women. The present study aimed to evaluate the cardiometabolic and inflammatory profiles of women in northeastern Brazil with respect to COC use and obesity. Methods: We performed a cross-sectional study to verify cardiovascular parameters, including blood pressure (BP), fasting serum glucose, lipid, and inflammatory profile, in a population of women aged 15–45 years, considering obesity and COC use. Our sample consisted of 591 women, 481 women who were COC users, and 110 age-matched women who were COC non-users, classified as obese and non-obese according to BMI.Results: COC use and obesity were associated with increased systolic (p ≤ 0.001) and diastolic BP (p = 0.001), blood glucose (p ≤ 0.001), total cholesterol (p = 0.008), low-density lipoprotein cholesterol (p ≤ 0.001), very low-density lipoprotein cholesterol (p ≤ 0.001), triglycerides (p ≤ 0.001), ferritin (p = 0.006), C-reactive protein (CRP) (p ≤ 0.001), and nitric oxide metabolites (p ≤ 0.001), as well as decreased high-density lipoprotein cholesterol (HDL-c) (p ≤ 0.001) in comparison to controls. CRP and HDL-c levels in obese COC users were determined to be outside reference range values. The odds of having lower levels of HDL-c and elevated CRP increased among obese COC users. COC use was independently associated with low levels of HDL-c, especially second-generation progestins (p < 0.001; OR = 8.976; 95% CI 2.786–28.914). Conclusion: Obesity and COC use were associated with alterations in lipid and inflammatory cardiometabolic parameters, particularly increased CRP levels and decreased HDL-c, which are considered markers of cardiovascular disease (CVD) risk. Given the need to prevent unintended pregnancy among obese women, together with weight loss counseling, it is important to evaluate the most effective and safest contraceptive methods to avoid the potential risk of developing CVD.engFrontiers MediaContraceptivos orais combinadosObesidadeParâmetros cardiometabólicosMulheresProteína C-reativaColesterol de lipoproteínas de alta densidadeRisco cardiovascularCombined oral contraceptivesObesityCardiometabolic parametersWomenC-reactive proteinHigh-density lipoprotein cholesterolCardiovascular riskEvaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptivesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/22954/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFerreira JRD Evaluation....pdfFerreira JRD Evaluation....pdfapplication/pdf475375https://www.arca.fiocruz.br/bitstream/icict/22954/2/Ferreira%20JRD%20Evaluation....pdf8a3eb17fe4acc97f6513e92990e8dd81MD52TEXTFerreira JRD Evaluation....pdf.txtFerreira JRD Evaluation....pdf.txtExtracted texttext/plain46953https://www.arca.fiocruz.br/bitstream/icict/22954/3/Ferreira%20JRD%20Evaluation....pdf.txt04034bc83238dd9ff53c81f04130be48MD53icict/229542023-03-15 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| dc.title.pt_BR.fl_str_mv |
Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives |
| title |
Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives |
| spellingShingle |
Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives Ferreira, Júnia Raquel Dutra Contraceptivos orais combinados Obesidade Parâmetros cardiometabólicos Mulheres Proteína C-reativa Colesterol de lipoproteínas de alta densidade Risco cardiovascular Combined oral contraceptives Obesity Cardiometabolic parameters Women C-reactive protein High-density lipoprotein cholesterol Cardiovascular risk |
| title_short |
Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives |
| title_full |
Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives |
| title_fullStr |
Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives |
| title_full_unstemmed |
Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives |
| title_sort |
Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives |
| author |
Ferreira, Júnia Raquel Dutra |
| author_facet |
Ferreira, Júnia Raquel Dutra Aleluia, Milena Magalhães Figueiredo, Camylla Vilas Boas Vieira, Larissa Castro de Lima Santiago, Rayra Pereira Guarda, Caroline Conceição da Barbosa, Cynara Gomes Oliveira, Ricardo Riccio Adorno, Elisângela Vitória Gonçalves, Marilda de Souza |
| author_role |
author |
| author2 |
Aleluia, Milena Magalhães Figueiredo, Camylla Vilas Boas Vieira, Larissa Castro de Lima Santiago, Rayra Pereira Guarda, Caroline Conceição da Barbosa, Cynara Gomes Oliveira, Ricardo Riccio Adorno, Elisângela Vitória Gonçalves, Marilda de Souza |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ferreira, Júnia Raquel Dutra Aleluia, Milena Magalhães Figueiredo, Camylla Vilas Boas Vieira, Larissa Castro de Lima Santiago, Rayra Pereira Guarda, Caroline Conceição da Barbosa, Cynara Gomes Oliveira, Ricardo Riccio Adorno, Elisângela Vitória Gonçalves, Marilda de Souza |
| dc.subject.other.pt_BR.fl_str_mv |
Contraceptivos orais combinados Obesidade Parâmetros cardiometabólicos Mulheres Proteína C-reativa Colesterol de lipoproteínas de alta densidade Risco cardiovascular |
| topic |
Contraceptivos orais combinados Obesidade Parâmetros cardiometabólicos Mulheres Proteína C-reativa Colesterol de lipoproteínas de alta densidade Risco cardiovascular Combined oral contraceptives Obesity Cardiometabolic parameters Women C-reactive protein High-density lipoprotein cholesterol Cardiovascular risk |
| dc.subject.en.pt_BR.fl_str_mv |
Combined oral contraceptives Obesity Cardiometabolic parameters Women C-reactive protein High-density lipoprotein cholesterol Cardiovascular risk |
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“Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ)” |
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2017 |
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2017-10-25T12:19:38Z |
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2017-10-25T12:19:38Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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FERREIRA, J. R. D. et al. Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives. Frontiers in Endocrinology, v. 8, sept. 2017. |
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https://www.arca.fiocruz.br/handle/icict/22954 |
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1664-2392 |
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10.3389/fendo.2017.00256 |
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FERREIRA, J. R. D. et al. Evaluation of Cardiometabolic Parameters among Obese Women Using Oral Contraceptives. Frontiers in Endocrinology, v. 8, sept. 2017. 1664-2392 10.3389/fendo.2017.00256 |
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Frontiers Media |
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