Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation

Detalhes bibliográficos
Autor(a) principal: Freitas, Luiz Antonio Rodrigues de
Data de Publicação: 1986
Outros Autores: Chevallier, Michele, Louis, Dominique, Grimaud, Jean-Alexis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15072
Resumo: lnstitut Pasteur. Laboratoire de Pathologie Cellulaire du Foie. Lyon, France / Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / UFBA, Salvador, BA, Brasil
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spelling Freitas, Luiz Antonio Rodrigues deChevallier, MicheleLouis, DominiqueGrimaud, Jean-Alexis2016-07-08T19:01:58Z2016-07-22T13:13:54Z2016-07-08T19:01:58Z2016-07-22T13:13:54Z1986FREITAS, L. A. R. et al. Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation. Liver, v. 6, p. 253-261, 1986.0106-9543https://www.arca.fiocruz.br/handle/icict/15072engWileyHuman extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlelnstitut Pasteur. Laboratoire de Pathologie Cellulaire du Foie. Lyon, France / Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / UFBA, Salvador, BA, Brasillnstitut Pasteur. Laboratoire de Pathologie Cellulaire du Foie. Lyon, Francelnstitut Pasteur. Centre de Microchirurgie Experimentale. Lyon, Francelnstitut Pasteur. Laboratoire de Pathologie Cellulaire du Foie. Lyon, FranceSurgical bile flow restoration in extrahepatic biliary atresia (EHBA) does not prevent the development of ongoing hepatic fibrosis and cirrhosis. Portal connective matrix was studied on liver biopsies obtained from seven children submitted to portoenterostomy. Electron microscopy and immunohistochemical techniques (using specific antibodies directed against collagen isotypes and associated glycoproteins) were performed. The study of extracellular and cellular components of connective mat ix demonstrated the existence of two distinct areas according to their situation with regard to ductular proliferation: loose connective matrix - mainly composed of fi, iectin, type 111 collagen, type 1V collagen and laminin - associated with microvessels and myofibroblasts proliferation characterized periportal zones adjacent to bile ductules; in areas distant from ductular proliferation, connective matrix appeared dense, composed of type I and type 111 collagen associated with fibroblasts. The connective matrix pattern observed in periductular areas can be compared to that described in cicatricial and hypertrophic processes where the myofibroblastic cell population is known to play an important role in fibrosis development. Although the connective matrix activation process remains unclear in EHBA, it may be suggested that activation of a connective tissue cellular clone might be responsible for this portal fibromatosisCollagen immunotypingHuman extrahepaticBiliary atresiaPortal connective tissueUltrastructureinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTFreitas LAR Human extra.pdf.txtFreitas LAR Human extra.pdf.txtExtracted texttext/plain22732https://www.arca.fiocruz.br/bitstream/icict/15072/4/Freitas%20LAR%20Human%20extra.pdf.txtcfa47688189320324690fe6776283affMD54ORIGINALFreitas LAR Human extra.pdfapplication/pdf3286744https://www.arca.fiocruz.br/bitstream/icict/15072/2/Freitas%20LAR%20Human%20extra.pdfa39969a6669146e73f3744f53d649a48MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/15072/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/150722023-03-15 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dc.title.pt_BR.fl_str_mv Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation
title Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation
spellingShingle Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation
Freitas, Luiz Antonio Rodrigues de
Collagen immunotyping
Human extrahepatic
Biliary atresia
Portal connective tissue
Ultrastructure
title_short Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation
title_full Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation
title_fullStr Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation
title_full_unstemmed Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation
title_sort Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation
author Freitas, Luiz Antonio Rodrigues de
author_facet Freitas, Luiz Antonio Rodrigues de
Chevallier, Michele
Louis, Dominique
Grimaud, Jean-Alexis
author_role author
author2 Chevallier, Michele
Louis, Dominique
Grimaud, Jean-Alexis
author2_role author
author
author
dc.contributor.author.fl_str_mv Freitas, Luiz Antonio Rodrigues de
Chevallier, Michele
Louis, Dominique
Grimaud, Jean-Alexis
dc.subject.en.pt_BR.fl_str_mv Collagen immunotyping
Human extrahepatic
Biliary atresia
Portal connective tissue
Ultrastructure
topic Collagen immunotyping
Human extrahepatic
Biliary atresia
Portal connective tissue
Ultrastructure
description lnstitut Pasteur. Laboratoire de Pathologie Cellulaire du Foie. Lyon, France / Fundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / UFBA, Salvador, BA, Brasil
publishDate 1986
dc.date.issued.fl_str_mv 1986
dc.date.accessioned.fl_str_mv 2016-07-08T19:01:58Z
2016-07-22T13:13:54Z
dc.date.available.fl_str_mv 2016-07-08T19:01:58Z
2016-07-22T13:13:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREITAS, L. A. R. et al. Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation. Liver, v. 6, p. 253-261, 1986.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15072
dc.identifier.issn.pt_BR.fl_str_mv 0106-9543
identifier_str_mv FREITAS, L. A. R. et al. Human extrahepatic biliary atresia: portal connective tissue activation related to ductular proliferation. Liver, v. 6, p. 253-261, 1986.
0106-9543
url https://www.arca.fiocruz.br/handle/icict/15072
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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