Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Bomfim, Lays Gisele Santos
Data de Publicação: 2017
Outros Autores: Magalhães, Lucas S, Santos Filho, Marcello Augusto Anchieta, Peres, Nalu Teixeira de Aguiar, Corrêa, Cristiane B, Tanajura, Diego Moura, Silva, Angela Maraia da, Lipscomb, Michael W, Borges, Valéria de Matos, Jesus, Amélia Ribeiro de, Almeida, Roque Pacheco de, Moura, Tatiana Rodrigues de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/24965
Resumo: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), MCTI/CNPQ/Universal 14/2014—460743/2014-7 (TdM) and PROCAD/CASADINHO—n◦552721/2011-5 (RA); Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe FAPITEC/SE/FUNTEC/CNPq n◦12/2009—019.203.02712/2009-8 (AJ); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Programa Nacional de Incentivo à Pesquisa em Parasitologia Básica, Edital No 032/2010 (AJ); National Institute Health, NIH Grant# SC2GM103741 (ML); Department of Defense, DOD Grant# W911NF-14-1-0123, (ML); and National Science Foundation, NSF Grant# 1428768, (ML).
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spelling Bomfim, Lays Gisele SantosMagalhães, Lucas SSantos Filho, Marcello Augusto AnchietaPeres, Nalu Teixeira de AguiarCorrêa, Cristiane BTanajura, Diego MouraSilva, Angela Maraia daLipscomb, Michael WBorges, Valéria de MatosJesus, Amélia Ribeiro deAlmeida, Roque Pacheco deMoura, Tatiana Rodrigues de2018-02-27T14:05:57Z2018-02-27T14:05:57Z2017BOMFIM, L. G. S. et al. Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis. Frontiers in Microbiology, v. 8, Article 2265, 2017.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/2496510.3389/fmicb.2017.02265Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), MCTI/CNPQ/Universal 14/2014—460743/2014-7 (TdM) and PROCAD/CASADINHO—n◦552721/2011-5 (RA); Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe FAPITEC/SE/FUNTEC/CNPq n◦12/2009—019.203.02712/2009-8 (AJ); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Programa Nacional de Incentivo à Pesquisa em Parasitologia Básica, Edital No 032/2010 (AJ); National Institute Health, NIH Grant# SC2GM103741 (ML); Department of Defense, DOD Grant# W911NF-14-1-0123, (ML); and National Science Foundation, NSF Grant# 1428768, (ML).Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilHoward University. Department of Biology. Washington, DC, USAFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilUniversidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, BrasilVisceral leishmaniasis (VL) is a systemic transmissible disease that remains to be a major global health problem. The inflammatory response during VL is characterized by the release of several cytokines and other pro-inflammatory mediators. Triggering Receptor Expressed on Myeloid Cells (TREM) are a group of evolutionarily conserved membrane-bound surface receptors expressed on neutrophils and monocytes. Engagement of TREM-1 directs intracellular signaling events that drive cytokine production, degranulation, and phagocytosis. In certain inflammatory-associated diseases, TREM-1 can also be found as a soluble form (sTREM-1), which can negatively regulate TREM-1 receptor signaling. In these studies, we now find that high levels of circulating sTREM-1 correlate directly with VL disease severity. In particular, high levels of sTREM-1 were observed in non-survivor VL patients. Furthermore, these levels of sTREM-1 positively correlated with liver size and negatively correlated with leukocyte counts and hemoglobin concentration. Moreover, we found that neutrophils exposurein vitrotoLeishmania infantummodulates TREM-1, DAP12, and IL-8 gene expression, while also increasing release of sTREM-1. Finally, results revealed that higher sTREM-1 levels are associated with increasing parasite ratio. Taken together, these studies suggest thatL. infantummay modulate TREM-1 in neutrophils and high levels of this molecule is associated with severe VL.engFrontiers MediaLeishmaniose visceralLeishmania infantumNeutrófilossTREM-1TREM-1Visceral leishmaniasisLeishmania infantumNeutrophilssTREM-1TREM-1Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24965/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBomfim LG Leishmania infantum Induces....pdfBomfim LG Leishmania infantum 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dc.title.pt_BR.fl_str_mv Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis
title Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis
spellingShingle Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis
Bomfim, Lays Gisele Santos
Leishmaniose visceral
Leishmania infantum
Neutrófilos
sTREM-1
TREM-1
Visceral leishmaniasis
Leishmania infantum
Neutrophils
sTREM-1
TREM-1
title_short Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis
title_full Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis
title_fullStr Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis
title_full_unstemmed Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis
title_sort Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis
author Bomfim, Lays Gisele Santos
author_facet Bomfim, Lays Gisele Santos
Magalhães, Lucas S
Santos Filho, Marcello Augusto Anchieta
Peres, Nalu Teixeira de Aguiar
Corrêa, Cristiane B
Tanajura, Diego Moura
Silva, Angela Maraia da
Lipscomb, Michael W
Borges, Valéria de Matos
Jesus, Amélia Ribeiro de
Almeida, Roque Pacheco de
Moura, Tatiana Rodrigues de
author_role author
author2 Magalhães, Lucas S
Santos Filho, Marcello Augusto Anchieta
Peres, Nalu Teixeira de Aguiar
Corrêa, Cristiane B
Tanajura, Diego Moura
Silva, Angela Maraia da
Lipscomb, Michael W
Borges, Valéria de Matos
Jesus, Amélia Ribeiro de
Almeida, Roque Pacheco de
Moura, Tatiana Rodrigues de
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bomfim, Lays Gisele Santos
Magalhães, Lucas S
Santos Filho, Marcello Augusto Anchieta
Peres, Nalu Teixeira de Aguiar
Corrêa, Cristiane B
Tanajura, Diego Moura
Silva, Angela Maraia da
Lipscomb, Michael W
Borges, Valéria de Matos
Jesus, Amélia Ribeiro de
Almeida, Roque Pacheco de
Moura, Tatiana Rodrigues de
dc.subject.other.pt_BR.fl_str_mv Leishmaniose visceral
Leishmania infantum
Neutrófilos
sTREM-1
TREM-1
topic Leishmaniose visceral
Leishmania infantum
Neutrófilos
sTREM-1
TREM-1
Visceral leishmaniasis
Leishmania infantum
Neutrophils
sTREM-1
TREM-1
dc.subject.en.pt_BR.fl_str_mv Visceral leishmaniasis
Leishmania infantum
Neutrophils
sTREM-1
TREM-1
description Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), MCTI/CNPQ/Universal 14/2014—460743/2014-7 (TdM) and PROCAD/CASADINHO—n◦552721/2011-5 (RA); Fundação de Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe FAPITEC/SE/FUNTEC/CNPq n◦12/2009—019.203.02712/2009-8 (AJ); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Programa Nacional de Incentivo à Pesquisa em Parasitologia Básica, Edital No 032/2010 (AJ); National Institute Health, NIH Grant# SC2GM103741 (ML); Department of Defense, DOD Grant# W911NF-14-1-0123, (ML); and National Science Foundation, NSF Grant# 1428768, (ML).
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-02-27T14:05:57Z
dc.date.available.fl_str_mv 2018-02-27T14:05:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv BOMFIM, L. G. S. et al. Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis. Frontiers in Microbiology, v. 8, Article 2265, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/24965
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2017.02265
identifier_str_mv BOMFIM, L. G. S. et al. Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis. Frontiers in Microbiology, v. 8, Article 2265, 2017.
1664-302X
10.3389/fmicb.2017.02265
url https://www.arca.fiocruz.br/handle/icict/24965
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Frontiers Media
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