A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice
| Autor(a) principal: | |
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| Data de Publicação: | 2006 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2741 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Brustolim, DanieleSantos, Ricardo Ribeiro dosKast, R. E.Altschuler, E. L.Soares, Milena Botelho Pereira2011-07-01T18:17:31Z2011-07-01T18:17:31Z2006BRUSTOLIM, D. et al. A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice. International Immunopharmacology, v. 6, n. 6, p. 903-907, 2006.1567-5769https://www.arca.fiocruz.br/handle/icict/274110.1016/j.intimp.2005.12.007engBupropionaDoença de CrohnDopaminaInflamaçãoInterferon gamaNorepinefrinaFator de necrose tumoral alfaBupropionCrohn's diseaseDopamineInflammationInterferon-gammaNorepinephrineTumor necrosis factor-alphaBupropionaDoença de CrohnDopaminaInflamaçãoInterferon gamaNorepinefrinaFator de Necrose Tumoral alfaA new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of Vermont. Department of Psychiatry. Vermont, USANew Jersey School of Medicine and Dentistry. Department of Physical Medicine and Rehabilitation, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilIn a wide range of human diseases of inflammatory nature like Crohn's disease, pathology is mediated in part by proinflammatory cytokines like tumor necrosis factor-alpha (TNF) or interferon-gamma. We show here that a commonly used generic antidepressant bupropion, in wide use worldwide to treat depression in humans for a decade now, profoundly lowers levels of TNF, interferon-gamma, and interleukin-1 beta in vivo, in a mouse lipopolysaccharide (LPS) induced inflammation model. Mice challenged with an otherwise lethal dose of LPS were protected by bupropion and levels of the anti-inflammatory cytokine interleukin-10 were increased. Previous data in rodents and humans indicate antidepressant effects of bupropion are mediated by its weak reuptake inhibition of norepinephrine and dopamine. Concordant with this, TNF suppression by bupropion in our mouse LPS model was largely abrogated by beta-adrenergic or dopamine D1 receptor antagonists but not by a D2 antagonist. TNF synthesis is controlled by an inverse relationship with intracellular cyclic adenosine monophosphate (cAMP) and stimulation of either betaadrenoreceptors or D1 dopaminergic receptors result in increased cAMP but stimulation of D2 receptors lowers cAMP. We conclude that bupropion may suppress TNF synthesis by mediating increased signaling at beta-adrenoreceptors and D1 receptors, resulting in increased cAMP that inhibits TNF synthesis. Bupropion is well tolerated also in non-psychiatric populations and has less risk with long term use than current anti-inflammatory, immunosuppressive or TNF suppressive treatments such as prednisone, azathioprine, infliximab, or methotrexate. New anti-inflammatory treatments are needed. We believe a new chapter in antiinflammatory, TNF lowering treatment of disease has been opened. Bupropion's use for this in humans should be explored. © 2006 Elsevier B.V. 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| dc.title.pt_BR.fl_str_mv |
A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice |
| title |
A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice |
| spellingShingle |
A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice Brustolim, Daniele Bupropiona Doença de Crohn Dopamina Inflamação Interferon gama Norepinefrina Fator de necrose tumoral alfa Bupropion Crohn's disease Dopamine Inflammation Interferon-gamma Norepinephrine Tumor necrosis factor-alpha Bupropiona Doença de Crohn Dopamina Inflamação Interferon gama Norepinefrina Fator de Necrose Tumoral alfa |
| title_short |
A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice |
| title_full |
A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice |
| title_fullStr |
A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice |
| title_full_unstemmed |
A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice |
| title_sort |
A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice |
| author |
Brustolim, Daniele |
| author_facet |
Brustolim, Daniele Santos, Ricardo Ribeiro dos Kast, R. E. Altschuler, E. L. Soares, Milena Botelho Pereira |
| author_role |
author |
| author2 |
Santos, Ricardo Ribeiro dos Kast, R. E. Altschuler, E. L. Soares, Milena Botelho Pereira |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Brustolim, Daniele Santos, Ricardo Ribeiro dos Kast, R. E. Altschuler, E. L. Soares, Milena Botelho Pereira |
| dc.subject.other.pt_BR.fl_str_mv |
Bupropiona Doença de Crohn Dopamina Inflamação Interferon gama Norepinefrina Fator de necrose tumoral alfa |
| topic |
Bupropiona Doença de Crohn Dopamina Inflamação Interferon gama Norepinefrina Fator de necrose tumoral alfa Bupropion Crohn's disease Dopamine Inflammation Interferon-gamma Norepinephrine Tumor necrosis factor-alpha Bupropiona Doença de Crohn Dopamina Inflamação Interferon gama Norepinefrina Fator de Necrose Tumoral alfa |
| dc.subject.en.pt_BR.fl_str_mv |
Bupropion Crohn's disease Dopamine Inflammation Interferon-gamma Norepinephrine Tumor necrosis factor-alpha |
| dc.subject.decs.pt_BR.fl_str_mv |
Bupropiona Doença de Crohn Dopamina Inflamação Interferon gama Norepinefrina Fator de Necrose Tumoral alfa |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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2006 |
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2006 |
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2011-07-01T18:17:31Z |
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2011-07-01T18:17:31Z |
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BRUSTOLIM, D. et al. A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice. International Immunopharmacology, v. 6, n. 6, p. 903-907, 2006. |
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1567-5769 |
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10.1016/j.intimp.2005.12.007 |
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BRUSTOLIM, D. et al. A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice. International Immunopharmacology, v. 6, n. 6, p. 903-907, 2006. 1567-5769 10.1016/j.intimp.2005.12.007 |
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