Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America

Detalhes bibliográficos
Autor(a) principal: Fernandes, Rosilainy S.
Data de Publicação: 2019
Outros Autores: Bersot, Maria I., Castro, Marcia G., Telleria, Erich Loza, Brito, Anielly Ferreira de, Raphael, Lidiane M., Bonaldo, Myrna C., Oliveira, Ricardo Lourenço de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41071
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.
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spelling Fernandes, Rosilainy S.Bersot, Maria I.Castro, Marcia G.Telleria, Erich LozaBrito, Anielly Ferreira deRaphael, Lidiane M.Bonaldo, Myrna C.Oliveira, Ricardo Lourenço de2020-05-03T17:43:51Z2020-05-03T17:43:51Z2019FERNANDES, Rosilainy S. et al. Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America. Scientific Reports, v. 9, p. 1-7, 2019.2045-2322https://www.arca.fiocruz.br/handle/icict/4107110.1038/s41598-019-56669-4engNature ResearchZika virusMosquitos silvestresBaixa competência vetorialCiclo enzoóticoAmérica do SulZika virusLow vector competenceSylvatic mosquitoesenzootic cycleSouth AmericaLow vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South Americainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ, Brasil / Charles University. Faculty of Science. Department of Parasitology. Prague, Czech Republic.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.Zika virus (ZIKV) has spread in the Americas since 2015 and the potential establishment of a sylvatic transmission cycle in the continent has been hypothesized. We evaluated vector competence of five sylvatic Neotropical mosquito species to two ZIKV isolates. Distinct batches of Haemagogus leucoceleanus, Sabethes albiprivus, Sabethes identicus, Aedes terrens and Aedes scapularis females were respectively orally challenged and inoculated intrathoracically with ZIKV. Orally challenged mosquitoes were refractory or exhibited low infection rates. Viral dissemination was detected only in Hg. leucocelaenus, but with very low rates. Virus was not detected in saliva of any mosquito orally challenged with ZIKV, regardless of viral isolate and incubation time. When intrathoracically injected, ZIKV disseminated in high rates in Hg. leucocelaenus, Sa. identicus and Sa. albpiprivus, but low transmission was detected in these species; very low dissemination and no transmission was detected in Ae. terrens and Ae. scapularis. Together these results suggest that genetically determined tissue barriers, especially in the midgut, play a vital role in inhibiting ZIKV for transmission in the tested sylvatic mosquito species. Thus, an independent enzootic transmission cycle for ZIKV in South America is very unlikely.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41071/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRLOliveira_MarciaGCastro_etal_IOC_2019.pdfRLOliveira_MarciaGCastro_etal_IOC_2019.pdfapplication/pdf1578297https://www.arca.fiocruz.br/bitstream/icict/41071/2/RLOliveira_MarciaGCastro_etal_IOC_2019.pdfc3061b92b26b8672bb2a70c602d8b830MD52TEXTRLOliveira_MarciaGCastro_etal_IOC_2019.pdf.txtRLOliveira_MarciaGCastro_etal_IOC_2019.pdf.txtExtracted texttext/plain32060https://www.arca.fiocruz.br/bitstream/icict/41071/3/RLOliveira_MarciaGCastro_etal_IOC_2019.pdf.txta8e7e8d4df39647216b3353980602598MD53icict/410712020-05-04 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dc.title.pt_BR.fl_str_mv Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America
title Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America
spellingShingle Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America
Fernandes, Rosilainy S.
Zika virus
Mosquitos silvestres
Baixa competência vetorial
Ciclo enzoótico
América do Sul
Zika virus
Low vector competence
Sylvatic mosquitoes
enzootic cycle
South America
title_short Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America
title_full Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America
title_fullStr Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America
title_full_unstemmed Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America
title_sort Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America
author Fernandes, Rosilainy S.
author_facet Fernandes, Rosilainy S.
Bersot, Maria I.
Castro, Marcia G.
Telleria, Erich Loza
Brito, Anielly Ferreira de
Raphael, Lidiane M.
Bonaldo, Myrna C.
Oliveira, Ricardo Lourenço de
author_role author
author2 Bersot, Maria I.
Castro, Marcia G.
Telleria, Erich Loza
Brito, Anielly Ferreira de
Raphael, Lidiane M.
Bonaldo, Myrna C.
Oliveira, Ricardo Lourenço de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Rosilainy S.
Bersot, Maria I.
Castro, Marcia G.
Telleria, Erich Loza
Brito, Anielly Ferreira de
Raphael, Lidiane M.
Bonaldo, Myrna C.
Oliveira, Ricardo Lourenço de
dc.subject.other.pt_BR.fl_str_mv Zika virus
Mosquitos silvestres
Baixa competência vetorial
Ciclo enzoótico
América do Sul
topic Zika virus
Mosquitos silvestres
Baixa competência vetorial
Ciclo enzoótico
América do Sul
Zika virus
Low vector competence
Sylvatic mosquitoes
enzootic cycle
South America
dc.subject.en.pt_BR.fl_str_mv Zika virus
Low vector competence
Sylvatic mosquitoes
enzootic cycle
South America
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-05-03T17:43:51Z
dc.date.available.fl_str_mv 2020-05-03T17:43:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERNANDES, Rosilainy S. et al. Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America. Scientific Reports, v. 9, p. 1-7, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41071
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-019-56669-4
identifier_str_mv FERNANDES, Rosilainy S. et al. Low vector competence in sylvatic mosquitoes limits Zika virus to initiate an enzootic cycle in South America. Scientific Reports, v. 9, p. 1-7, 2019.
2045-2322
10.1038/s41598-019-56669-4
url https://www.arca.fiocruz.br/handle/icict/41071
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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