Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/48489 |
Resumo: | Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. |
| id |
CRUZ_90c2e7f8fe2504ca7a84cf0b56dd5b06 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/48489 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Goudouris, Ekaterini SimõesPinto‑Mariz, FernandaMendonça, Leonardo OliveiraAranda, Carolina SanchezGuimarães, Rafaela RollaKokron, CristinaBarros, Myrthes ToledoAnísio, FláviaAlonso, Maria Luiza OlivaMarcelino, FernandaValle, Solange Oliveira RodriguesDortas Junior, SergioBarreto, Irma Douglas PaesFerreira, Janáira Fernandes SeveroRoxo‑Junior, PérsioSilva, Almerinda Maria do RegoCampinhos, Fernanda LugãoBonfim, CarmemLoth, GiseleFernandes, Juliana FolloniGarcia, Julia LopesCapelo, AlbertinaTakano, Olga AkikoNadaf, Maria Isabel ValdomirToledo, Eliana C.Cunha, Luciana Araújo OliveiraGesu, Regina Sumiko Watanabe DiSchidlowski, LaireFillipo, PriscilaBichuetti‑Silva, Daniélli C.Soldateli, GustavoFerraroni, Natasha RebouçasDantas, Ellen de OliveiraPestana, SimoneMansour, EliUlaf, Raisa GussoPrando, CarolinaCondino‑Neto, AntonioGrumach, Anete Sevciovic2021-08-04T11:43:09Z2021-08-04T11:43:09Z2021GOUDOURIS, Ekaterini Simões et al. Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study. Journal of Clinical Immunology, v. 23, p. 1-11, Jun. 2021.0271-9142https://www.arca.fiocruz.br/handle/icict/4848910.1007/s10875-021-01066-81573-2592engSpringerOutcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Hospital 9 de Julho. Clinica Croce and Center for Rare Diseases .São Paulo, SP, Brasil.Universidade Federal de São Paulo. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Imunologia. Rio de Janeiro, RJ, Brasil.Hospital Regional da Asa Norte. Departamento de Alergia e Imunologia. Brasília, DF, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Imunologia. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Pará, Belem, PA, Brasil.Hospital Infantil Albert Sabin. Fortaleza, CE, Brasil / Universidade Estadual do Ceará. Fortaleza, CE, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Serviço de Alergia e Imunologia Pediátrica. Ribeirão Preto, SP, Brasil.Universidade Federal de Pernambuco. Recife, PE, Brasil.Santa Casa de Misericórdia de Vitória. Escola Superior de Ciências. Vitoria, ES, Brasil.Hospital Pequeno Príncipe. Curitiba, PR, Brasil.Universidade Federal do Paraná. Hospital de Clinicas, Curitiba, PR, Brasil.Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Instituto do Tratamento do Cancer Infantil Instituto da Criança. São Paulo, SP. / Hospital Israelita Albert Einstein. São Paulo, SP, Brasil.Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, Rio de Janeiro, Brasil.Universidade Federal do Mato Grosso. Hospital Universitário Júlio Müller. Cuiabá, MT, Brasil.Universidade Federal do Mato Grosso. Hospital Universitário Júlio Müller. Cuiabá, MT, Brasil.Faculdade de Medicina de São José do Rio Preto. São José do Rio Preto, SP, Brasil.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.Hospital Criança Conceição. Departamento de Pediatria. Porto Alegre, RS, Brasil.Faculdades Pequeno Príncipe. Instituto de Pesquisa Pelé Pequeno Príncipe. Curitiba, PR, Brasil.Hospital Municipal Jesus. Rio de Janeiro, RJ, Brasil.Universidade Federal de Goiás. Goiânia, GO, Brasil.Hospital Infantil Joana de Gusmão. Florianópolis, SC, Brasil.Clínica Ferraroni, Brasília, DF, Brasil.Hospital Israelita Albert Einstein. São Paulo, SP, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.Universidade de Campinas. Departamento de Clínica Médica. Alergia e Imunologia. Campinas, SP, Brasil.Universidade de Campinas. Departamento de Clínica Médica. Alergia e Imunologia. Campinas, SP, Brasil.Hospital Pequeno Príncipe. Curitiba, PR, Brasil / Faculdades Pequeno Príncipe. Instituto de Pesquisa Pelé Pequeno Príncipe. Curitiba, PR, Brasil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Imunologia. São Paulo, SP.Centro Universitário Saúde ABC. Faculdade de Medicina. Santo Andre, SP, Brasil.Purpose: There is still scarce data on SARS-CoV-2 infection in patients with Inborn Errors of Immunity (IEI) and many unresolved questions. We aimed to describe the clinical outcome of SARS-CoV-2 infection in Brazilian IEI patients and identify factors influencing the infection. Methods: We did a cross-sectional, multicenter study that included patients of any age affected by IEI and SARS-CoV-2 infection. The variables studied were sex, age, type of IEI, comorbidities (number and type), treatment in use for IEI, clinical manifestations and severity of SARS-CoV-2 infection. Results: 121 patients were included: 55.4% female, ages from six months to 74 yo (median age = 25.1 yo). Most patients had predominantly antibody deficiency (n = 53). The infection was mostly asymptomatic (n = 21) and mild (n = 66), and one child had multisystem inflammatory syndrome (MIS-C). We could not observe sex-related susceptibility, and there was a weak correlation between age and severity of infection. The number of comorbidities was higher in severe cases, particularly bronchiectasis and cardiopathy. There were no severe cases in hereditary angioedema patients. Six patients aged 2 to 74 years died, three of them with antibody deficiency. Conclusion: The outcome was mild in most patients, but the Case Fatality Ratio was higher than in the general population. However, the type of IEI was not a determining factor for severity, except for complement deficiencies linked to milder COVID-19. The severity of SARS-CoV-2 infection seems to be more related to older age, a higher number of comorbidities and type of comorbidities (bronchiectasis and cardiopathy).COVID-19CoronavirusSARS-CoV-2Primary immunodeficiencyInborn errors of immunityImmunodeficiencyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83134https://www.arca.fiocruz.br/bitstream/icict/48489/1/license.txt0ab46789d568c4ba27c7b5d29a9fe9c4MD51ORIGINALOutcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity - A Cross-Sectional Study.pdfOutcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity - A Cross-Sectional Study.pdfapplication/pdf1007118https://www.arca.fiocruz.br/bitstream/icict/48489/2/Outcome%20of%20SARS-CoV-2%20Infection%20in%20121%20Patients%20with%20Inborn%20Errors%20of%20Immunity%20-%20A%20Cross-Sectional%20Study.pdfe929bd286f34b3e4dba9b96e4049d4d7MD52TEXTOutcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity - A Cross-Sectional Study.pdf.txtOutcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity - A Cross-Sectional Study.pdf.txtExtracted texttext/plain52844https://www.arca.fiocruz.br/bitstream/icict/48489/3/Outcome%20of%20SARS-CoV-2%20Infection%20in%20121%20Patients%20with%20Inborn%20Errors%20of%20Immunity%20-%20A%20Cross-Sectional%20Study.pdf.txt1a52e7a5f5578ab5afdf857fae20e7c2MD53icict/484892021-11-25 14:46:00.074oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-11-25T17:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en.fl_str_mv |
Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study |
| title |
Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study |
| spellingShingle |
Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study Goudouris, Ekaterini Simões COVID-19 Coronavirus SARS-CoV-2 Primary immunodeficiency Inborn errors of immunity Immunodeficiency |
| title_short |
Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study |
| title_full |
Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study |
| title_fullStr |
Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study |
| title_full_unstemmed |
Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study |
| title_sort |
Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study |
| author |
Goudouris, Ekaterini Simões |
| author_facet |
Goudouris, Ekaterini Simões Pinto‑Mariz, Fernanda Mendonça, Leonardo Oliveira Aranda, Carolina Sanchez Guimarães, Rafaela Rolla Kokron, Cristina Barros, Myrthes Toledo Anísio, Flávia Alonso, Maria Luiza Oliva Marcelino, Fernanda Valle, Solange Oliveira Rodrigues Dortas Junior, Sergio Barreto, Irma Douglas Paes Ferreira, Janáira Fernandes Severo Roxo‑Junior, Pérsio Silva, Almerinda Maria do Rego Campinhos, Fernanda Lugão Bonfim, Carmem Loth, Gisele Fernandes, Juliana Folloni Garcia, Julia Lopes Capelo, Albertina Takano, Olga Akiko Nadaf, Maria Isabel Valdomir Toledo, Eliana C. Cunha, Luciana Araújo Oliveira Gesu, Regina Sumiko Watanabe Di Schidlowski, Laire Fillipo, Priscila Bichuetti‑Silva, Daniélli C. Soldateli, Gustavo Ferraroni, Natasha Rebouças Dantas, Ellen de Oliveira Pestana, Simone Mansour, Eli Ulaf, Raisa Gusso Prando, Carolina Condino‑Neto, Antonio Grumach, Anete Sevciovic |
| author_role |
author |
| author2 |
Pinto‑Mariz, Fernanda Mendonça, Leonardo Oliveira Aranda, Carolina Sanchez Guimarães, Rafaela Rolla Kokron, Cristina Barros, Myrthes Toledo Anísio, Flávia Alonso, Maria Luiza Oliva Marcelino, Fernanda Valle, Solange Oliveira Rodrigues Dortas Junior, Sergio Barreto, Irma Douglas Paes Ferreira, Janáira Fernandes Severo Roxo‑Junior, Pérsio Silva, Almerinda Maria do Rego Campinhos, Fernanda Lugão Bonfim, Carmem Loth, Gisele Fernandes, Juliana Folloni Garcia, Julia Lopes Capelo, Albertina Takano, Olga Akiko Nadaf, Maria Isabel Valdomir Toledo, Eliana C. Cunha, Luciana Araújo Oliveira Gesu, Regina Sumiko Watanabe Di Schidlowski, Laire Fillipo, Priscila Bichuetti‑Silva, Daniélli C. Soldateli, Gustavo Ferraroni, Natasha Rebouças Dantas, Ellen de Oliveira Pestana, Simone Mansour, Eli Ulaf, Raisa Gusso Prando, Carolina Condino‑Neto, Antonio Grumach, Anete Sevciovic |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Goudouris, Ekaterini Simões Pinto‑Mariz, Fernanda Mendonça, Leonardo Oliveira Aranda, Carolina Sanchez Guimarães, Rafaela Rolla Kokron, Cristina Barros, Myrthes Toledo Anísio, Flávia Alonso, Maria Luiza Oliva Marcelino, Fernanda Valle, Solange Oliveira Rodrigues Dortas Junior, Sergio Barreto, Irma Douglas Paes Ferreira, Janáira Fernandes Severo Roxo‑Junior, Pérsio Silva, Almerinda Maria do Rego Campinhos, Fernanda Lugão Bonfim, Carmem Loth, Gisele Fernandes, Juliana Folloni Garcia, Julia Lopes Capelo, Albertina Takano, Olga Akiko Nadaf, Maria Isabel Valdomir Toledo, Eliana C. Cunha, Luciana Araújo Oliveira Gesu, Regina Sumiko Watanabe Di Schidlowski, Laire Fillipo, Priscila Bichuetti‑Silva, Daniélli C. Soldateli, Gustavo Ferraroni, Natasha Rebouças Dantas, Ellen de Oliveira Pestana, Simone Mansour, Eli Ulaf, Raisa Gusso Prando, Carolina Condino‑Neto, Antonio Grumach, Anete Sevciovic |
| dc.subject.en.pt_BR.fl_str_mv |
COVID-19 Coronavirus SARS-CoV-2 Primary immunodeficiency Inborn errors of immunity Immunodeficiency |
| topic |
COVID-19 Coronavirus SARS-CoV-2 Primary immunodeficiency Inborn errors of immunity Immunodeficiency |
| description |
Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2021 |
| dc.date.accessioned.fl_str_mv |
2021-08-04T11:43:09Z |
| dc.date.available.fl_str_mv |
2021-08-04T11:43:09Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
GOUDOURIS, Ekaterini Simões et al. Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study. Journal of Clinical Immunology, v. 23, p. 1-11, Jun. 2021. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/48489 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0271-9142 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1007/s10875-021-01066-8 |
| dc.identifier.eissn.pt_BR.fl_str_mv |
1573-2592 |
| identifier_str_mv |
GOUDOURIS, Ekaterini Simões et al. Outcome of SARS‑CoV‑2 infection in 121 patients with inborn errors of immunity: a cross‑sectional study. Journal of Clinical Immunology, v. 23, p. 1-11, Jun. 2021. 0271-9142 10.1007/s10875-021-01066-8 1573-2592 |
| url |
https://www.arca.fiocruz.br/handle/icict/48489 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Springer |
| publisher.none.fl_str_mv |
Springer |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/48489/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/48489/2/Outcome%20of%20SARS-CoV-2%20Infection%20in%20121%20Patients%20with%20Inborn%20Errors%20of%20Immunity%20-%20A%20Cross-Sectional%20Study.pdf https://www.arca.fiocruz.br/bitstream/icict/48489/3/Outcome%20of%20SARS-CoV-2%20Infection%20in%20121%20Patients%20with%20Inborn%20Errors%20of%20Immunity%20-%20A%20Cross-Sectional%20Study.pdf.txt |
| bitstream.checksum.fl_str_mv |
0ab46789d568c4ba27c7b5d29a9fe9c4 e929bd286f34b3e4dba9b96e4049d4d7 1a52e7a5f5578ab5afdf857fae20e7c2 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1798324839071612928 |