Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia

Detalhes bibliográficos
Autor(a) principal: Vitral, Claudia Lamarca
Data de Publicação: 2014
Outros Autores: Nunes, Mônica da Silva, Pinto, Marcelo Alves, Oliveira, Jaqueline Mendes de, Gaspar, Ana Maria Coimbra, Pereira, Rebeca Cristina Costa, Ferreira, Marcelo Urbano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10270
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.
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spelling Vitral, Claudia LamarcaNunes, Mônica da SilvaPinto, Marcelo AlvesOliveira, Jaqueline Mendes deGaspar, Ana Maria CoimbraPereira, Rebeca Cristina CostaFerreira, Marcelo Urbano2015-05-08T14:08:46Z2015-05-08T14:08:46Z2014VITRAL, Claudia Lamarca et al. Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia. BMC Infectious Diseases, v.14, n.458 , 9p, 2014.https://www.arca.fiocruz.br/handle/icict/1027010.1186/1471-2334-14-458.engBiomed CentralHepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazoniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, BrasilUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Background: Hepatitis A virus (HAV) and hepatitis E virus (HEV) are both transmitted by the faecal-oral route, and represent common causes of acute hepatitis in developing countries. The endemicity of HAV infection has shifted from high to moderate in Brazil. Human cases of HEV infection seem to be rare, although the virus has been detected in swine livestock and effluents of slaughterhouses. This study was to determine the epidemiology of hepatitis A and E in one of the largest agricultural settlements in the Amazon Basin of Brazil. Methods: Serum samples collected from 397 individuals aged between 5 and 90 years during a population-based cross-sectional survey were tested for anti-HAV and anti-HEV antibodies. Associated risk factors and spatial clustering of HAV and HEV seropositivity were also analyzed. Results: The overall rate of HAV seropositivity was 82.9% (95% confidence interval (CI), 79.2-86.6%). Multilevel logistic regression analysis identified increasing age (in years; odds ratio (OR), 1.097; 95% CI, 1.050-1.147; P < 0.001) and crowding (OR, 1.603; 95% CI, 1.054-2.440; P = 0.028) as significant risk factors for HAV seropositivity. Anti-HEV IgG was detected in 50/388 settlers (12.9%, 95% CI, 9.5-16.2%). Anti-HEV IgM was detected in 7/43 (16.3%) anti-IgG positive samples, and 4 of them had a confirmed result by immunoblot. Increasing age was the only significant determinant of HEV seropositivity (OR, 1.033; 95% CI, 1.016-1.050; P < 0.001). No significant spatial clustering of HAV and HEV seropositivity was detected in the area. Conclusions: Both HAV and HEV are endemic, with differing rates of infection in children and adults in this rural setting of the Brazilian Amazon. Anti-HEV prevalence was considerably higher than those previously reported in Brazil. The detection of HEV- specific IgM antibodies in four asymptomatic individuals is highly suggestive of the circulation of HEV in this rural population.Hepatitis AHepatitis ESeroprevalenceAmazon basinEstudos SoroepidemiológicosHepatite AHepatite Einfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10270/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALclaudia_vitraletal_IOC_2014.pdfapplication/pdf302560https://www.arca.fiocruz.br/bitstream/icict/10270/2/claudia_vitraletal_IOC_2014.pdf70eef2c7e5aef8b8aed164fbba33d135MD52TEXTclaudia_vitraletal_IOC_2014.pdf.txtclaudia_vitraletal_IOC_2014.pdf.txtExtracted texttext/plain47808https://www.arca.fiocruz.br/bitstream/icict/10270/3/claudia_vitraletal_IOC_2014.pdf.txtb82366f1b268583ee32f16e404e564f0MD53icict/102702022-06-24 13:12:37.901oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:12:37Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia
title Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia
spellingShingle Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia
Vitral, Claudia Lamarca
Hepatitis A
Hepatitis E
Seroprevalence
Amazon basin
Estudos Soroepidemiológicos
Hepatite A
Hepatite E
title_short Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia
title_full Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia
title_fullStr Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia
title_full_unstemmed Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia
title_sort Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia
author Vitral, Claudia Lamarca
author_facet Vitral, Claudia Lamarca
Nunes, Mônica da Silva
Pinto, Marcelo Alves
Oliveira, Jaqueline Mendes de
Gaspar, Ana Maria Coimbra
Pereira, Rebeca Cristina Costa
Ferreira, Marcelo Urbano
author_role author
author2 Nunes, Mônica da Silva
Pinto, Marcelo Alves
Oliveira, Jaqueline Mendes de
Gaspar, Ana Maria Coimbra
Pereira, Rebeca Cristina Costa
Ferreira, Marcelo Urbano
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vitral, Claudia Lamarca
Nunes, Mônica da Silva
Pinto, Marcelo Alves
Oliveira, Jaqueline Mendes de
Gaspar, Ana Maria Coimbra
Pereira, Rebeca Cristina Costa
Ferreira, Marcelo Urbano
dc.subject.en.pt_BR.fl_str_mv Hepatitis A
Hepatitis E
Seroprevalence
Amazon basin
topic Hepatitis A
Hepatitis E
Seroprevalence
Amazon basin
Estudos Soroepidemiológicos
Hepatite A
Hepatite E
dc.subject.decs.pt_BR.fl_str_mv Estudos Soroepidemiológicos
Hepatite A
Hepatite E
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Instituto Biomédico. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-08T14:08:46Z
dc.date.available.fl_str_mv 2015-05-08T14:08:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv VITRAL, Claudia Lamarca et al. Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia. BMC Infectious Diseases, v.14, n.458 , 9p, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10270
dc.identifier.doi.pt_BR.fl_str_mv 10.1186/1471-2334-14-458.
identifier_str_mv VITRAL, Claudia Lamarca et al. Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia. BMC Infectious Diseases, v.14, n.458 , 9p, 2014.
10.1186/1471-2334-14-458.
url https://www.arca.fiocruz.br/handle/icict/10270
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Biomed Central
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