Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.

Lyra, Andre Castro; Soares, Milena Botelho Pereira; Silva, Luiz Flavio Maia da; Braga, Eduardo Lorens; Oliveira, Sheilla Andrade de; Fortes, Marcos Fraga; Silva, André Goyanna Pinheiro; Brustolim, Daniele; Genser, Bernd; Santos, Ricardo Ribeiro dos; Lyra, Luiz Guilherme Costa

Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.

Detalhes bibliográficos
Autor(a) principal:	Lyra, Andre Castro
Data de Publicação:	2010
Outros Autores:	Soares, Milena Botelho Pereira, Silva, Luiz Flavio Maia da, Braga, Eduardo Lorens, Oliveira, Sheilla Andrade de, Fortes, Marcos Fraga, Silva, André Goyanna Pinheiro, Brustolim, Daniele, Genser, Bernd, Santos, Ricardo Ribeiro dos, Lyra, Luiz Guilherme Costa
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/8988
Resumo:	Hospital Sao Rafael. Salvador, BA, Brasil / Hospital Universitário Professor Edgard Santos. Federal Univeristy of Bahia. Medicine-Gastro-Hepatology Service. Salvador, BA, Brasil

Metadados do item

id	CRUZ_91800e057ba9fc8c9c10a34cfc0545b3
oai_identifier_str	oai:www.arca.fiocruz.br:icict/8988
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Lyra, Andre CastroSoares, Milena Botelho PereiraSilva, Luiz Flavio Maia daBraga, Eduardo LorensOliveira, Sheilla Andrade deFortes, Marcos FragaSilva, André Goyanna PinheiroBrustolim, DanieleGenser, BerndSantos, Ricardo Ribeiro dosLyra, Luiz Guilherme Costa2014-11-27T19:40:51Z2014-11-27T19:40:51Z2010LYRA, A. C. et al. Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. European Journal of Gastroenterology & Hepatology, v. 22, n. 1, p. 33-42, 20101473-5687https://www.arca.fiocruz.br/handle/icict/898810.1097/MEG.0b013e32832eb69aengLippincott Williams & WilkinsInfusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Sao Rafael. Salvador, BA, Brasil / Hospital Universitário Professor Edgard Santos. Federal Univeristy of Bahia. Medicine-Gastro-Hepatology Service. Salvador, BA, BrasilHospital São Rafael. Regenerative Medicine. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital Sao Rafael. Medicine. Hematology. Salvador, BA, BrasilHospital Sao Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Radiology. Salvador, BA, BrasilHospital São Rafael. Regenerative Medicine. Salvador, BA, BrasilBGStats Consulting. Graz, AustriaHospital São Rafael. Regenerative Medicine. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital Sao Rafael. Salvador, BA, BrasilAIM: This randomized controlled study evaluated the effect of autologous infusion of bone marrow cells (BMC) in patients with hepatic cirrhosis. METHODS: Thirty patients on the liver transplant waiting list were randomly assigned to receive BMC therapy or no treatment. They were followed up for 1 year. The study was nonblinded. Autologous mononuclear-enriched BMC were infused into the hepatic artery; liver function scores/tests were chosen as endpoints to assess efficacy. Statistical analysis calculated mean relative changes (RC) from baseline and fitted a random-effects model. RESULTS: Mean age, baseline model for end-stage liver disease, and Child-Pugh score were similar in both groups. Child-Pugh score improved in the first 90 days in the cell therapy group compared with controls (P = 0.017, BMC group RC = -8%, controls RC = +5%). The model for end-stage liver disease score remained stable in the treated patients (RC -2 to +6%), whereas it increased during follow-up in the control group (RC +6 to +18%). Albumin levels improved in the treatment arm, whereas they remained stable among controls in the first 90 days (P = 0.034; BMC group RC = +16%, control group RC = +2%). Bilirubin levels increased among controls, whereas they decreased in the therapy arm during the first 60 days; INR RC differences between groups reached up to 10%. The changes observed did not persist beyond 90 days. CONCLUSION: Transplantation of autologous BMC into the hepatic artery improved liver function in patients with advanced cirrhosis in the first 90 days. However, larger studies are necessary to define the role of BMC therapy in cirrhotic patients. Repeated autologous BMC infusions or combination therapy with granulocyte-colony-stimulating factor might improve or sustain the treatment response.Bone marrow stem cell transplantationCD34+Cell therapyChronic liver diseaseCirrhosisTransplante de Medula Óssea/métodosCirrose Hepática/terapiaAdolescenteAdultoIdosoBilirrubina/sangueDoença CrônicaMétodos EpidemiológicosFemininoArtéria HepáticaHumanosCirrose Hepática/sangueTransplante de FígadoMasculinoMeia-IdadeTempo de ProtrombinaAlbumina Sérica/metabolismoListas de EsperaAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8988/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALLyra AC Infusion of....pdfLyra AC Infusion of....pdfapplication/pdf209231https://www.arca.fiocruz.br/bitstream/icict/8988/2/Lyra%20AC%20%20Infusion%20of....pdfe2e73897c822b277bd8642ef46389981MD52TEXTLyra AC Infusion of....pdf.txtLyra AC Infusion of....pdf.txtExtracted texttext/plain41810https://www.arca.fiocruz.br/bitstream/icict/8988/3/Lyra%20AC%20%20Infusion%20of....pdf.txt2b8f47d5328b0a6454f92f57e1a799fcMD53icict/89882023-03-15 14:33:04.726oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.
title	Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.
spellingShingle	Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. Lyra, Andre Castro Bone marrow stem cell transplantation CD34+ Cell therapy Chronic liver disease Cirrhosis Transplante de Medula Óssea/métodos Cirrose Hepática/terapia Adolescente Adulto Idoso Bilirrubina/sangue Doença Crônica Métodos Epidemiológicos Feminino Artéria Hepática Humanos Cirrose Hepática/sangue Transplante de Fígado Masculino Meia-Idade Tempo de Protrombina Albumina Sérica/metabolismo Listas de Espera Adulto Jovem
title_short	Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.
title_full	Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.
title_fullStr	Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.
title_full_unstemmed	Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.
title_sort	Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.
author	Lyra, Andre Castro
author_facet	Lyra, Andre Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Braga, Eduardo Lorens Oliveira, Sheilla Andrade de Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Brustolim, Daniele Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa
author_role	author
author2	Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Braga, Eduardo Lorens Oliveira, Sheilla Andrade de Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Brustolim, Daniele Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa
author2_role	author author author author author author author author author author
dc.contributor.author.fl_str_mv	Lyra, Andre Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Braga, Eduardo Lorens Oliveira, Sheilla Andrade de Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Brustolim, Daniele Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa
dc.subject.en.pt_BR.fl_str_mv	Bone marrow stem cell transplantation CD34+ Cell therapy Chronic liver disease Cirrhosis
topic	Bone marrow stem cell transplantation CD34+ Cell therapy Chronic liver disease Cirrhosis Transplante de Medula Óssea/métodos Cirrose Hepática/terapia Adolescente Adulto Idoso Bilirrubina/sangue Doença Crônica Métodos Epidemiológicos Feminino Artéria Hepática Humanos Cirrose Hepática/sangue Transplante de Fígado Masculino Meia-Idade Tempo de Protrombina Albumina Sérica/metabolismo Listas de Espera Adulto Jovem
dc.subject.decs.pt_BR.fl_str_mv	Transplante de Medula Óssea/métodos Cirrose Hepática/terapia Adolescente Adulto Idoso Bilirrubina/sangue Doença Crônica Métodos Epidemiológicos Feminino Artéria Hepática Humanos Cirrose Hepática/sangue Transplante de Fígado Masculino Meia-Idade Tempo de Protrombina Albumina Sérica/metabolismo Listas de Espera Adulto Jovem
description	Hospital Sao Rafael. Salvador, BA, Brasil / Hospital Universitário Professor Edgard Santos. Federal Univeristy of Bahia. Medicine-Gastro-Hepatology Service. Salvador, BA, Brasil
publishDate	2010
dc.date.issued.fl_str_mv	2010
dc.date.accessioned.fl_str_mv	2014-11-27T19:40:51Z
dc.date.available.fl_str_mv	2014-11-27T19:40:51Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	LYRA, A. C. et al. Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. European Journal of Gastroenterology & Hepatology, v. 22, n. 1, p. 33-42, 2010
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/8988
dc.identifier.issn.none.fl_str_mv	1473-5687
dc.identifier.eissn.none.fl_str_mv	10.1097/MEG.0b013e32832eb69a
identifier_str_mv	LYRA, A. C. et al. Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. European Journal of Gastroenterology & Hepatology, v. 22, n. 1, p. 33-42, 2010 1473-5687 10.1097/MEG.0b013e32832eb69a
url	https://www.arca.fiocruz.br/handle/icict/8988
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Lippincott Williams & Wilkins
publisher.none.fl_str_mv	Lippincott Williams & Wilkins
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/8988/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/8988/2/Lyra%20AC%20%20Infusion%20of....pdf https://www.arca.fiocruz.br/bitstream/icict/8988/3/Lyra%20AC%20%20Infusion%20of....pdf.txt
bitstream.checksum.fl_str_mv	7d48279ffeed55da8dfe2f8e81f3b81f e2e73897c822b277bd8642ef46389981 2b8f47d5328b0a6454f92f57e1a799fc
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1798324944730324992

Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.

Registros relacionados