Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8988 |
Resumo: | Hospital Sao Rafael. Salvador, BA, Brasil / Hospital Universitário Professor Edgard Santos. Federal Univeristy of Bahia. Medicine-Gastro-Hepatology Service. Salvador, BA, Brasil |
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Lyra, Andre CastroSoares, Milena Botelho PereiraSilva, Luiz Flavio Maia daBraga, Eduardo LorensOliveira, Sheilla Andrade deFortes, Marcos FragaSilva, André Goyanna PinheiroBrustolim, DanieleGenser, BerndSantos, Ricardo Ribeiro dosLyra, Luiz Guilherme Costa2014-11-27T19:40:51Z2014-11-27T19:40:51Z2010LYRA, A. C. et al. Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. European Journal of Gastroenterology & Hepatology, v. 22, n. 1, p. 33-42, 20101473-5687https://www.arca.fiocruz.br/handle/icict/898810.1097/MEG.0b013e32832eb69aengLippincott Williams & WilkinsInfusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Sao Rafael. Salvador, BA, Brasil / Hospital Universitário Professor Edgard Santos. Federal Univeristy of Bahia. Medicine-Gastro-Hepatology Service. Salvador, BA, BrasilHospital São Rafael. Regenerative Medicine. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital Sao Rafael. Medicine. Hematology. Salvador, BA, BrasilHospital Sao Rafael. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital São Rafael. Radiology. Salvador, BA, BrasilHospital São Rafael. Regenerative Medicine. Salvador, BA, BrasilBGStats Consulting. Graz, AustriaHospital São Rafael. Regenerative Medicine. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilHospital Sao Rafael. Salvador, BA, BrasilAIM: This randomized controlled study evaluated the effect of autologous infusion of bone marrow cells (BMC) in patients with hepatic cirrhosis. METHODS: Thirty patients on the liver transplant waiting list were randomly assigned to receive BMC therapy or no treatment. They were followed up for 1 year. The study was nonblinded. Autologous mononuclear-enriched BMC were infused into the hepatic artery; liver function scores/tests were chosen as endpoints to assess efficacy. Statistical analysis calculated mean relative changes (RC) from baseline and fitted a random-effects model. RESULTS: Mean age, baseline model for end-stage liver disease, and Child-Pugh score were similar in both groups. Child-Pugh score improved in the first 90 days in the cell therapy group compared with controls (P = 0.017, BMC group RC = -8%, controls RC = +5%). The model for end-stage liver disease score remained stable in the treated patients (RC -2 to +6%), whereas it increased during follow-up in the control group (RC +6 to +18%). Albumin levels improved in the treatment arm, whereas they remained stable among controls in the first 90 days (P = 0.034; BMC group RC = +16%, control group RC = +2%). Bilirubin levels increased among controls, whereas they decreased in the therapy arm during the first 60 days; INR RC differences between groups reached up to 10%. The changes observed did not persist beyond 90 days. CONCLUSION: Transplantation of autologous BMC into the hepatic artery improved liver function in patients with advanced cirrhosis in the first 90 days. However, larger studies are necessary to define the role of BMC therapy in cirrhotic patients. Repeated autologous BMC infusions or combination therapy with granulocyte-colony-stimulating factor might improve or sustain the treatment response.Bone marrow stem cell transplantationCD34+Cell therapyChronic liver diseaseCirrhosisTransplante de Medula Óssea/métodosCirrose Hepática/terapiaAdolescenteAdultoIdosoBilirrubina/sangueDoença CrônicaMétodos EpidemiológicosFemininoArtéria HepáticaHumanosCirrose Hepática/sangueTransplante de FígadoMasculinoMeia-IdadeTempo de ProtrombinaAlbumina Sérica/metabolismoListas de EsperaAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8988/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALLyra AC Infusion of....pdfLyra AC Infusion of....pdfapplication/pdf209231https://www.arca.fiocruz.br/bitstream/icict/8988/2/Lyra%20AC%20%20Infusion%20of....pdfe2e73897c822b277bd8642ef46389981MD52TEXTLyra AC Infusion of....pdf.txtLyra AC Infusion of....pdf.txtExtracted texttext/plain41810https://www.arca.fiocruz.br/bitstream/icict/8988/3/Lyra%20AC%20%20Infusion%20of....pdf.txt2b8f47d5328b0a6454f92f57e1a799fcMD53icict/89882023-03-15 14:33:04.726oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. |
title |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. |
spellingShingle |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. Lyra, Andre Castro Bone marrow stem cell transplantation CD34+ Cell therapy Chronic liver disease Cirrhosis Transplante de Medula Óssea/métodos Cirrose Hepática/terapia Adolescente Adulto Idoso Bilirrubina/sangue Doença Crônica Métodos Epidemiológicos Feminino Artéria Hepática Humanos Cirrose Hepática/sangue Transplante de Fígado Masculino Meia-Idade Tempo de Protrombina Albumina Sérica/metabolismo Listas de Espera Adulto Jovem |
title_short |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. |
title_full |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. |
title_fullStr |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. |
title_full_unstemmed |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. |
title_sort |
Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. |
author |
Lyra, Andre Castro |
author_facet |
Lyra, Andre Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Braga, Eduardo Lorens Oliveira, Sheilla Andrade de Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Brustolim, Daniele Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
author_role |
author |
author2 |
Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Braga, Eduardo Lorens Oliveira, Sheilla Andrade de Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Brustolim, Daniele Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lyra, Andre Castro Soares, Milena Botelho Pereira Silva, Luiz Flavio Maia da Braga, Eduardo Lorens Oliveira, Sheilla Andrade de Fortes, Marcos Fraga Silva, André Goyanna Pinheiro Brustolim, Daniele Genser, Bernd Santos, Ricardo Ribeiro dos Lyra, Luiz Guilherme Costa |
dc.subject.en.pt_BR.fl_str_mv |
Bone marrow stem cell transplantation CD34+ Cell therapy Chronic liver disease Cirrhosis |
topic |
Bone marrow stem cell transplantation CD34+ Cell therapy Chronic liver disease Cirrhosis Transplante de Medula Óssea/métodos Cirrose Hepática/terapia Adolescente Adulto Idoso Bilirrubina/sangue Doença Crônica Métodos Epidemiológicos Feminino Artéria Hepática Humanos Cirrose Hepática/sangue Transplante de Fígado Masculino Meia-Idade Tempo de Protrombina Albumina Sérica/metabolismo Listas de Espera Adulto Jovem |
dc.subject.decs.pt_BR.fl_str_mv |
Transplante de Medula Óssea/métodos Cirrose Hepática/terapia Adolescente Adulto Idoso Bilirrubina/sangue Doença Crônica Métodos Epidemiológicos Feminino Artéria Hepática Humanos Cirrose Hepática/sangue Transplante de Fígado Masculino Meia-Idade Tempo de Protrombina Albumina Sérica/metabolismo Listas de Espera Adulto Jovem |
description |
Hospital Sao Rafael. Salvador, BA, Brasil / Hospital Universitário Professor Edgard Santos. Federal Univeristy of Bahia. Medicine-Gastro-Hepatology Service. Salvador, BA, Brasil |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2014-11-27T19:40:51Z |
dc.date.available.fl_str_mv |
2014-11-27T19:40:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LYRA, A. C. et al. Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. European Journal of Gastroenterology & Hepatology, v. 22, n. 1, p. 33-42, 2010 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/8988 |
dc.identifier.issn.none.fl_str_mv |
1473-5687 |
dc.identifier.eissn.none.fl_str_mv |
10.1097/MEG.0b013e32832eb69a |
identifier_str_mv |
LYRA, A. C. et al. Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study. European Journal of Gastroenterology & Hepatology, v. 22, n. 1, p. 33-42, 2010 1473-5687 10.1097/MEG.0b013e32832eb69a |
url |
https://www.arca.fiocruz.br/handle/icict/8988 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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