Compensatory lung growth after bilobectomy in emphysematous rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23541 |
Resumo: | Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. |
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Almeida, Francine MariaRomanholo, Beatriz Mangueira SaraivaVieira, Rodolfo PaulaMoriya, Henrique TakachiOliveira, Ana Paula Ligeiro deLopes, Fernanda DtqsFaria Neto, Hugo C.Mauad, ThaisMartins, Milton ArrudaPazetti, Rogerio2017-12-07T13:54:20Z2017-12-07T13:54:20Z2017ALMEIDA, Francine Maria; et al. Compensatory lung growth after bilobectomy in emphysematous rats. Plos One, v.12, n.7, e0181819, 14p, July 2017.1932-6203https://www.arca.fiocruz.br/handle/icict/2354110.1371/journal.pone.0181819engPublic Library of ScienceCirurgia de redução do volume pulmonarpacientes enfisematososBilobectomiaLung volume reduction surgeryemphysematous patientsbilobectomyCompensatory lung growth after bilobectomy in emphysematous ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil /Instituto de Assistência Médica ao Servidor Público Estadual. Universidade Cidade de São Paulo. São Paulo, SP, Brasil.Universidade Brasil Escola de Ciências Médicas de São José dos Campos Humanitas. Instituto Brasileiro de Ensino e Pesquisa em Imunologia Pulmonar e de Exercício. São Paulo, BrasilUniversidade de São Paulo. Laboratório de Engenharia Biomédica. São Paulo, SP, BrasilUniversidade Brasil Escola de Ciências Médicas de São José dos Campos Humanitas. Instituto Brasileiro de Ensino e Pesquisa em Imunologia Pulmonar e de Exercício. São Paulo, BrasilUniversidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas. Cardiopneumologia. São Paulo, SP, brasilLung volume reduction surgery (LVRS) is an option for emphysematous patients who are awaiting lung transplantation. LVRS reduces nonfunctional portions of lung tissues and favors the compensatory lung growth (CLG) of the remaining lobes. This phenomenon diminishes dyspnea and improves both the respiratory mechanics and quality of life for the patients. An animal model of elastase-induced pulmonary emphysema was used to investigate the structural and functional lung response after LVRS. Bilobectomy was performed six weeks after elastase instillation. Two weeks after bilobectomy, CLG effects were evaluated by lung mechanics and histomorphometric analysis. After bilobectomy, the emphysematous animals presented decreased mean linear intercepts, increased elastic fiber proportion, and increased alveolar surface density, total volumes of airspace, tissue and respiratory region and absolute surface area. We conclude that bilobectomy promoted CLG in emphysematous animals, resulting in alveolar architecture repair.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23541/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALhugocastro2_farianeto_etal_IOC_2017.pdfhugocastro2_farianeto_etal_IOC_2017.pdfapplication/pdf16023890https://www.arca.fiocruz.br/bitstream/icict/23541/2/hugocastro2_farianeto_etal_IOC_2017.pdf0ea8b60f0fa462ef5bbfcbf3ade1d16fMD52TEXThugocastro2_farianeto_etal_IOC_2017.pdf.txthugocastro2_farianeto_etal_IOC_2017.pdf.txtExtracted texttext/plain43767https://www.arca.fiocruz.br/bitstream/icict/23541/3/hugocastro2_farianeto_etal_IOC_2017.pdf.txt75bce7662ca2003a4fd7fe4a8ffc4045MD53icict/235412018-08-15 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| dc.title.pt_BR.fl_str_mv |
Compensatory lung growth after bilobectomy in emphysematous rats |
| title |
Compensatory lung growth after bilobectomy in emphysematous rats |
| spellingShingle |
Compensatory lung growth after bilobectomy in emphysematous rats Almeida, Francine Maria Cirurgia de redução do volume pulmonar pacientes enfisematosos Bilobectomia Lung volume reduction surgery emphysematous patients bilobectomy |
| title_short |
Compensatory lung growth after bilobectomy in emphysematous rats |
| title_full |
Compensatory lung growth after bilobectomy in emphysematous rats |
| title_fullStr |
Compensatory lung growth after bilobectomy in emphysematous rats |
| title_full_unstemmed |
Compensatory lung growth after bilobectomy in emphysematous rats |
| title_sort |
Compensatory lung growth after bilobectomy in emphysematous rats |
| author |
Almeida, Francine Maria |
| author_facet |
Almeida, Francine Maria Romanholo, Beatriz Mangueira Saraiva Vieira, Rodolfo Paula Moriya, Henrique Takachi Oliveira, Ana Paula Ligeiro de Lopes, Fernanda Dtqs Faria Neto, Hugo C. Mauad, Thais Martins, Milton Arruda Pazetti, Rogerio |
| author_role |
author |
| author2 |
Romanholo, Beatriz Mangueira Saraiva Vieira, Rodolfo Paula Moriya, Henrique Takachi Oliveira, Ana Paula Ligeiro de Lopes, Fernanda Dtqs Faria Neto, Hugo C. Mauad, Thais Martins, Milton Arruda Pazetti, Rogerio |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Almeida, Francine Maria Romanholo, Beatriz Mangueira Saraiva Vieira, Rodolfo Paula Moriya, Henrique Takachi Oliveira, Ana Paula Ligeiro de Lopes, Fernanda Dtqs Faria Neto, Hugo C. Mauad, Thais Martins, Milton Arruda Pazetti, Rogerio |
| dc.subject.other.pt_BR.fl_str_mv |
Cirurgia de redução do volume pulmonar pacientes enfisematosos Bilobectomia |
| topic |
Cirurgia de redução do volume pulmonar pacientes enfisematosos Bilobectomia Lung volume reduction surgery emphysematous patients bilobectomy |
| dc.subject.en.pt_BR.fl_str_mv |
Lung volume reduction surgery emphysematous patients bilobectomy |
| description |
Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil. |
| publishDate |
2017 |
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2017-12-07T13:54:20Z |
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2017-12-07T13:54:20Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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ALMEIDA, Francine Maria; et al. Compensatory lung growth after bilobectomy in emphysematous rats. Plos One, v.12, n.7, e0181819, 14p, July 2017. |
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https://www.arca.fiocruz.br/handle/icict/23541 |
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1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0181819 |
| identifier_str_mv |
ALMEIDA, Francine Maria; et al. Compensatory lung growth after bilobectomy in emphysematous rats. Plos One, v.12, n.7, e0181819, 14p, July 2017. 1932-6203 10.1371/journal.pone.0181819 |
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Public Library of Science |
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