Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging

Detalhes bibliográficos
Autor(a) principal: Costa, Maria Fernanda Lima
Data de Publicação: 2010
Outros Autores: Matos, Divane Leite, Ribeiro, Antonio Luiz P.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6548
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil.
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spelling Costa, Maria Fernanda LimaMatos, Divane LeiteRibeiro, Antonio Luiz P.2013-06-03T19:25:34Z2013-06-03T19:25:34Z2010LIMA COSTA, Maria Fernanda; MATOS, Divane Leite; RIBEIRO, Antonio Luiz. Chagas disease predicts 10-year stroke mortality in community-dwelling elderly (The Bambuí Cohort Study of Aging). Stroke, v. 145, p. 2477-2482, Nov. 2010.1524-4628https://www.arca.fiocruz.br/handle/icict/6548porAmerican Heart AssociationChagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aginginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil.Background and Purpose—Previous case– control studies have suggested a causal link between Chagas disease, which is caused by the protozoan Trypanosoma cruzi, and stroke. We investigated the relationship between Chagas disease and long-term stroke mortality in a large community-based cohort of older adults. Methods—Participants were 1398 (80.3% from total) residents aged _60 years in Bambuí City, Brazil. The end point was death from stroke. Potential confounding variables included age, sex, conventional stroke risk factors, and high sensitive C-reactive protein. Results—Participants of this study were followed from 1997 to 2007 leading to 9740 person-years of observation. The baseline prevalence of T. cruzi infection was 37.5% and the overall mortality rate from stroke was 4.62 per 1000 person-years. The risk of death from stroke among T. cruzi-infected participants was twice that of those noninfected (adjusted hazard ratio, 2.36; 95% CI, 1.25 to 4.44). A B-type natriuretic peptide level in the top quartile was a strong and independent predictor of stroke mortality among those infected (adjusted hazard ratio, 2.72; 95% CI, 1.25 to 5.91). The presence of both a high B-type natriuretic peptide level and electrocardiographic atrial fibrillation increased the risk of stroke mortality by 11.49 (95% CI, 3.19 to 41.38) in these individuals. Conclusions—This study provides new evidence supporting a causal link between Chagas disease and stroke. The results also showed that B-type natriuretic peptide alone or in association with atrial fibrillation has prognostic value for stroke mortality in T. cruzi chronically infected older adultsBrain natriuretic peptideStroke mortalityEpidemiologyEtiologyChagas diseaseTrypanosoma Cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALARCAReneRachou.pdfARCAReneRachou.pdfapplication/pdf1393000https://www.arca.fiocruz.br/bitstream/icict/6548/1/ARCAReneRachou.pdfd298efd08f133150b85b29afa7b0ccebMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6548/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTARCAReneRachou.pdf.txtARCAReneRachou.pdf.txtExtracted texttext/plain6https://www.arca.fiocruz.br/bitstream/icict/6548/5/ARCAReneRachou.pdf.txt6d93d3216dc4a7f5df47d4876fbec4d3MD55THUMBNAILARCAReneRachou.pdf.jpgARCAReneRachou.pdf.jpgGenerated Thumbnailimage/jpeg2093https://www.arca.fiocruz.br/bitstream/icict/6548/4/ARCAReneRachou.pdf.jpg26099a9212ff3c336ba46ad645529077MD54icict/65482018-05-17 12:12:30.838oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-05-17T15:12:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging
title Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging
spellingShingle Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging
Costa, Maria Fernanda Lima
Brain natriuretic peptide
Stroke mortality
Epidemiology
Etiology
Chagas disease
Trypanosoma Cruzi
title_short Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging
title_full Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging
title_fullStr Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging
title_full_unstemmed Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging
title_sort Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly The Bambuí Cohort Study of Aging
author Costa, Maria Fernanda Lima
author_facet Costa, Maria Fernanda Lima
Matos, Divane Leite
Ribeiro, Antonio Luiz P.
author_role author
author2 Matos, Divane Leite
Ribeiro, Antonio Luiz P.
author2_role author
author
dc.contributor.author.fl_str_mv Costa, Maria Fernanda Lima
Matos, Divane Leite
Ribeiro, Antonio Luiz P.
dc.subject.en.pt_BR.fl_str_mv Brain natriuretic peptide
Stroke mortality
Epidemiology
Etiology
Chagas disease
Trypanosoma Cruzi
topic Brain natriuretic peptide
Stroke mortality
Epidemiology
Etiology
Chagas disease
Trypanosoma Cruzi
description Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2013-06-03T19:25:34Z
dc.date.available.fl_str_mv 2013-06-03T19:25:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA COSTA, Maria Fernanda; MATOS, Divane Leite; RIBEIRO, Antonio Luiz. Chagas disease predicts 10-year stroke mortality in community-dwelling elderly (The Bambuí Cohort Study of Aging). Stroke, v. 145, p. 2477-2482, Nov. 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6548
dc.identifier.issn.none.fl_str_mv 1524-4628
identifier_str_mv LIMA COSTA, Maria Fernanda; MATOS, Divane Leite; RIBEIRO, Antonio Luiz. Chagas disease predicts 10-year stroke mortality in community-dwelling elderly (The Bambuí Cohort Study of Aging). Stroke, v. 145, p. 2477-2482, Nov. 2010.
1524-4628
url https://www.arca.fiocruz.br/handle/icict/6548
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language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv American Heart Association
publisher.none.fl_str_mv American Heart Association
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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