Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum

Detalhes bibliográficos
Autor(a) principal: Alves, A. S.
Data de Publicação: 2012
Outros Autores: Mouta-Confort, E., Figueiredo, F. B., Oliveira, R. V., Schubach, A. O., Madeira, M. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36730
Resumo: 2020-10-29
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spelling Alves, A. S.Mouta-Confort, E.Figueiredo, F. B.Oliveira, R. V.Schubach, A. O.Madeira, M. F.2019-10-29T12:41:59Z2019-10-29T12:41:59Z2012ALVES, A. S. et al. Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection byTrypanosoma caninum. Research in Veterinary Science, v. 93, p. 1329-1333, 2012.0034-5288https://www.arca.fiocruz.br/handle/icict/3673010.1016/j.rvsc.2012.07.0061532-2661engElsevierEvaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-10-29Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Programa de pós-graduação em Pesquisa Clínica em Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses de Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Epidemiologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.In order to evaluate if the presence of Trypanosoma caninum can lead to a confuse diagnosis of canine visceral leishmaniasis (CVL), we investigated the serological status of dogs infected by T. caninum and assessed the serological cross-reactivity with CVL. A set of 117 serum samples from dogs infected by T. caninum, Leishmania chagasi and not infected dogs (n = 39 in each group) was tested using commercial kits – indirect immunofluorescence (IFI-LVC), ELISA (EIE-LVC) and immunochromatographic test (DPP) – and in house tests with T. caninum (IIF-Tc and ELISA-Tc) and L. chagasi antigens (IIF-Lc and ELISA-Lc). IIF-Tc and ELISA-Tc presented sensitivity of 64.1% and 94.9% and specificity of 23.1% and 35.9%, respectively. The sensitivity of the IFI-LVC, EIE-LVC and DPP tests was 100% and the specificity was 70.5%, 68% and 97.5% respectively. The concordance between the tests was considered as satisfactory. The specificities of IFI-LVC, EIE-LVC and DPP were higher when the group Tc was excluded, with significant values for IFI-LVC (χ2 = 4.36, P-value = 0.036), thus suggesting that the infection by T. caninum can confuse the diagnosis of CVL.Leishmania chagasiTrypanosoma caninumDiagnosisCross reactionDogsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36730/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Alves_A_etal_INI_2012.pdfve_Alves_A_etal_INI_2012.pdfapplication/pdf291472https://www.arca.fiocruz.br/bitstream/icict/36730/2/ve_Alves_A_etal_INI_2012.pdf92c522269f929e110bdcdfcf40e08fd5MD52TEXTve_Alves_A_etal_INI_2012.pdf.txtve_Alves_A_etal_INI_2012.pdf.txtExtracted texttext/plain28038https://www.arca.fiocruz.br/bitstream/icict/36730/3/ve_Alves_A_etal_INI_2012.pdf.txtfffd988ee2883f874fef4fa25ddfb94bMD53icict/367302021-03-24 16:32:38.149oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:38Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum
title Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum
spellingShingle Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum
Alves, A. S.
Leishmania chagasi
Trypanosoma caninum
Diagnosis
Cross reaction
Dogs
title_short Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum
title_full Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum
title_fullStr Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum
title_full_unstemmed Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum
title_sort Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection by Trypanosoma caninum
author Alves, A. S.
author_facet Alves, A. S.
Mouta-Confort, E.
Figueiredo, F. B.
Oliveira, R. V.
Schubach, A. O.
Madeira, M. F.
author_role author
author2 Mouta-Confort, E.
Figueiredo, F. B.
Oliveira, R. V.
Schubach, A. O.
Madeira, M. F.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Alves, A. S.
Mouta-Confort, E.
Figueiredo, F. B.
Oliveira, R. V.
Schubach, A. O.
Madeira, M. F.
dc.subject.en.pt_BR.fl_str_mv Leishmania chagasi
Trypanosoma caninum
Diagnosis
Cross reaction
Dogs
topic Leishmania chagasi
Trypanosoma caninum
Diagnosis
Cross reaction
Dogs
description 2020-10-29
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-10-29T12:41:59Z
dc.date.available.fl_str_mv 2019-10-29T12:41:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALVES, A. S. et al. Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection byTrypanosoma caninum. Research in Veterinary Science, v. 93, p. 1329-1333, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36730
dc.identifier.issn.pt_BR.fl_str_mv 0034-5288
dc.identifier.doi.none.fl_str_mv 10.1016/j.rvsc.2012.07.006
dc.identifier.eissn.none.fl_str_mv 1532-2661
identifier_str_mv ALVES, A. S. et al. Evaluation of serological cross-reactivity between canine visceral leishmaniasis and natural infection byTrypanosoma caninum. Research in Veterinary Science, v. 93, p. 1329-1333, 2012.
0034-5288
10.1016/j.rvsc.2012.07.006
1532-2661
url https://www.arca.fiocruz.br/handle/icict/36730
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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