Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains

Detalhes bibliográficos
Autor(a) principal: Silva, Andreon Santos Machado da
Data de Publicação: 2021
Outros Autores: Albuquerque, Lawrence Henrique Paz, Ponte, Carlos Germano Garrido de, Almeida, Matheus Rogério de, Faria, Sandra Elizabete Ribeiro de, Ribeiro, Mariana da Silva, Pereira, Evelyn Nunes Goulart da Silva, Antas, Paulo Renato Zuquim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1080/21645515.2021.1989913
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50853
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil.
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spelling Silva, Andreon Santos Machado daAlbuquerque, Lawrence Henrique PazPonte, Carlos Germano Garrido deAlmeida, Matheus Rogério deFaria, Sandra Elizabete Ribeiro deRibeiro, Mariana da SilvaPereira, Evelyn Nunes Goulart da SilvaAntas, Paulo Renato Zuquim2022-01-23T16:47:50Z2022-01-23T16:47:50Z2021SILVA, Andreon Santos Machado da et al . Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains. Human Vaccines & Immunotherapeutics, p. 1-8, Nov. 2021.2164-5515https://www.arca.fiocruz.br/handle/icict/5085310.1080/21645515.2021.1989913engTaylor & FrancisTuberculoseVacina CGCitocinaMycobacterium bovis BCG MoreauMycobacterium bovis BCG RússiaDeformaçãoTuberculosisCG VaccineStrainsCytokineMycobacterium bovis BCG MoreauMycobacterium bovis BCG RussiaTime to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Tuberculosis (TB) has been a major public health problem worldwide, and the Bacillus Calmette–Guérin (BCG) vaccine is the only available vaccine against this disease. The BCG vaccine is no longer a single organism; it consists of diverse strains. The early-shared strains of the BCG vaccine are stronger immunostimulators than the late-shared strains. In this study, we have employed a simple in vitro human model to broadly evaluate the differences among four widely used BCG vaccines during the characterization of strain-specific host immune responses. In general, the BCG Moreau vaccine generated a higher inflammatory cytokine profile and lower TGF-β levels compared with the Russia, Pasteur, and Danish strains in the context of early sensitization with TB; however, no changes were observed in the IL-23 levels between infected and noninfected cultures. Unsurprisingly, the BCG vaccines provided different features, and the variances among those strains may influence the activation of infected host cells, which ultimately leads to distinct protective efficacy to tackle TB.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/50853/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAndreonMachadoSilva_MarianaSRibeiro_etal_IOC_2021.pdfAndreonMachadoSilva_MarianaSRibeiro_etal_IOC_2021.pdfapplication/pdf976872https://www.arca.fiocruz.br/bitstream/icict/50853/2/AndreonMachadoSilva_MarianaSRibeiro_etal_IOC_2021.pdf5f131e773014f61258368f4a2317637cMD52icict/508532022-01-23 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dc.title.pt_BR.fl_str_mv Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains
title Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains
spellingShingle Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains
Silva, Andreon Santos Machado da
Tuberculose
Vacina CG
Citocina
Mycobacterium bovis BCG Moreau
Mycobacterium bovis BCG Rússia
Deformação
Tuberculosis
CG Vaccine
Strains
Cytokine
Mycobacterium bovis BCG Moreau
Mycobacterium bovis BCG Russia
title_short Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains
title_full Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains
title_fullStr Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains
title_full_unstemmed Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains
title_sort Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains
author Silva, Andreon Santos Machado da
author_facet Silva, Andreon Santos Machado da
Albuquerque, Lawrence Henrique Paz
Ponte, Carlos Germano Garrido de
Almeida, Matheus Rogério de
Faria, Sandra Elizabete Ribeiro de
Ribeiro, Mariana da Silva
Pereira, Evelyn Nunes Goulart da Silva
Antas, Paulo Renato Zuquim
author_role author
author2 Albuquerque, Lawrence Henrique Paz
Ponte, Carlos Germano Garrido de
Almeida, Matheus Rogério de
Faria, Sandra Elizabete Ribeiro de
Ribeiro, Mariana da Silva
Pereira, Evelyn Nunes Goulart da Silva
Antas, Paulo Renato Zuquim
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Andreon Santos Machado da
Albuquerque, Lawrence Henrique Paz
Ponte, Carlos Germano Garrido de
Almeida, Matheus Rogério de
Faria, Sandra Elizabete Ribeiro de
Ribeiro, Mariana da Silva
Pereira, Evelyn Nunes Goulart da Silva
Antas, Paulo Renato Zuquim
dc.subject.other.pt_BR.fl_str_mv Tuberculose
Vacina CG
Citocina
Mycobacterium bovis BCG Moreau
Mycobacterium bovis BCG Rússia
Deformação
topic Tuberculose
Vacina CG
Citocina
Mycobacterium bovis BCG Moreau
Mycobacterium bovis BCG Rússia
Deformação
Tuberculosis
CG Vaccine
Strains
Cytokine
Mycobacterium bovis BCG Moreau
Mycobacterium bovis BCG Russia
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
CG Vaccine
Strains
Cytokine
Mycobacterium bovis BCG Moreau
Mycobacterium bovis BCG Russia
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB). Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-01-23T16:47:50Z
dc.date.available.fl_str_mv 2022-01-23T16:47:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Andreon Santos Machado da et al . Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains. Human Vaccines & Immunotherapeutics, p. 1-8, Nov. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50853
dc.identifier.issn.pt_BR.fl_str_mv 2164-5515
dc.identifier.doi.none.fl_str_mv 10.1080/21645515.2021.1989913
identifier_str_mv SILVA, Andreon Santos Machado da et al . Time to face the proofs: the BCG Moreau vaccine promotes superior inflammatory cytokine profile in vitro when compared with Russia, Pasteur, and Danish strains. Human Vaccines & Immunotherapeutics, p. 1-8, Nov. 2021.
2164-5515
10.1080/21645515.2021.1989913
url https://www.arca.fiocruz.br/handle/icict/50853
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50853/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50853/2/AndreonMachadoSilva_MarianaSRibeiro_etal_IOC_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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