Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA)

Detalhes bibliográficos
Autor(a) principal: Nicol, Alcina F.
Data de Publicação: 2008
Outros Autores: Rodrigues Cordovil Pires, Andréa, de Souza, Simone R., Nuovo, Gerard J., Grinsztejn, Beatriz, Tristão, Aparecida, Russomano, Fábio Bastos, Velasque, Luciane, Lapa e Silva, José R., Pirmez, Claude
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7342
Resumo: PN-DST/AIDS-MS-UNESCO, FAPERJ e IOC-FIOCRUZ
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spelling Nicol, Alcina F.Rodrigues Cordovil Pires, Andréade Souza, Simone R.Nuovo, Gerard J.Grinsztejn, BeatrizTristão, AparecidaRussomano, Fábio BastosVelasque, LucianeLapa e Silva, José R.Pirmez, Claude2014-02-20T14:24:07Z2014-02-20T14:24:07Z2008NICOL, Alcina F. et al. Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA). BMC Cancer, London, v. 8, n. 289, p. 1-10, 2008.1471-2407https://www.arca.fiocruz.br/handle/icict/734210.1186/1471-2407-8-289PN-DST/AIDS-MS-UNESCO, FAPERJ e IOC-FIOCRUZFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil. / Laboratório Fonte Medicina Diagnóstica, Niterói, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil. / Laboratório Fonte Medicina Diagnóstica, Niterói, RJ, Brasil.University Hospitals Columbus, Department of Pathology, Columbus, Ohio, USA.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. / Universidade Federal do Rio de Janeiro, Departamento de Matemática e Estatística. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil. / Universidade Federal do Rio de Janeiro, Departamento de Matemática e Estatística. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento Multidisciplinar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil.Background The oncoproteins of human papillomavirus (HPVs) directly effect cell-cycle control. We hypothesize that regulatory and cell cycle protein expression might be additionally modified in the cervix of HIV/HPV co-infected women. Methods We analyzed the expression of Rb, p27, VEGF and Elf-1 transcriptor factor by immunohistochemistry in 163 paraffin-embeded cervical samples using Tissue Micro-Array (TMA) and correlated this to HIV-1 and HPV infection. Results HIV/HPV co-infection was associated with a significant increase in expression (p < 0.001) of VEGF and p27 in both low and high grade CIN when compared to the cervices of women infected by HPV alone. Decreased Rb expression was evident with increased CIN grade in the cervices of women infected with HPV alone (p = 0.003 average of cells/mm2 in CIN I: 17.9, CIN II/III: 4.8, and tumor 3.9). Rb expression increased 3-fold for both low and high grade CIN with HPV/HIV-1 co-infection compared to HPV infection alone but did not reach statistical significance. There was a significant increase in Elf-1 expression in HPV+/HIV- women with CIN II/III and tumor (average of cells/mm2 in CIN I: 63.8; CIN II/III: 115.7 and tumor: 112.0, p = 0.005), in comparison to controls. Conclusion Co-infection of HPV and HIV leads to significant increase in the VEGF and p27 expression when compared to HPV+/HIV-negative infection that could facilitate viral persistence and invasive tumor development.engBioMed CentralTjalma W, van Waes T, van den Eeden L, Bogers J: Role of human papillomavirus in the carcinogenesis of squamous cell carcinoma and adenocarcinoma of the cervix. Best practice & Research Clin Obst Gynaecol 2005, 19(4):469-483.Cho HN, Kim TY, Kim JW: Alteration of cell cycle in cervical tumor associated with Human Papillomavirus – Cyclin-Dependent kinase inhibitors. Yonsei Med J 2002, 43(6):722-728.Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G: Inflammation and cancer: how hot is the link? Biochem Pharmacol 2006, 72(11):1605-21.Branca M, Giorgi C, Santini D, Di Bonito L, Ciotti M, Benedetto A, Paba P, Costa S, Bonifacio D, Di Bonito P, Accardi L, Favalli C, Syrjanen K: Aberrant expression of VEGF-C is related to grade of cervical intraepithelial neoplasia (CIN) and high risk HPV, but does not predict virus clearance after treatment of CIN or prognosis of cervical cancer. J Clin Pathol 2006, 59(1):40-7.Huang X, Brown C, Ni W, Maynard E, Rigby AC, Oetthen P: Critical role for the Ets transcription factor ELF-1 in the development of tumor angiogenesis. Blood 2006, 107(8):3153-3160.Troncone G, Vetrani A, de Rosa G, Palombini L: Cyclin dependent kinase inhibitor p27 expression in normal and neoplastic cervical epithelium. J Clin Pathol 1999, 52:880-887.Benevolo M, Mottolese M, Marandino F, Vocaturo G, Sindico R, Piperno G, Mariani L, Sperduti I, Canalini P, Donnorso RP, Vocaturo A: Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions. Mod Pathol 2006, 19(3):384-91.Wentzensen N, von Knebel Doeberitz M: Biomarkers in cervical cancer screening. Dis Markers 2007, 23(4):315-30.Nicol AF, Fernandes AT, Grinsztejn B, Russomano F, E Silva JR, Tristao A, Perez M, Nuovo GJ, Martinez-Maza O, Bonecini-Almeida M: Distribution of immune cell subsets and cytokine-producing cells in the uterine cervix of human papillomavirus (HPV)-infected women: influence of HIV-1 coinfection. Diagn Mol Pathol 2005, 14(1):39-47.Nicol AF, Nuovo GJ, Salomão-Estevez A, Grinsztein B, Tristão A, Russomano F, Lapa E Silva JR, Oliveira MP, Pirmez C: Immune factors involved in the cervical immune response in the HIV/HPV co-infection. J Clin Pathol 2008, 61(1):84-8.Gage JR, Sandhu AK, Nihira M, Bonecini-Almeida M da G, Cristoforoni P, Kishimoto T, Montz FJ, Martínez-Maza O: Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression. Obstet Gynecol 2000, 96(6):879-85.Nyagol J, Leucci E, Onnis A, De Falco G, Tigli C, Sanseverino F, Torriccelli M, Palummo N, Pacenti L, Santopietro R, Spina D, Gichangi P, Muchiri L, Lazzi S, Petraglia F, Leoncini L, Giordano A: The effects of HIV-1 Tat protein on cell cycle during cervical carcinogenesis. Cancer Biol Ther 2006, 5(6):684-90.Pires AR, da Matta Andreiuolo F, de Souza SR: TMA for all: a new method for the construction of tissue microarrays without recipient paraffin block using custom-built needles. Diagn Pathol 2006, 25(1):14.Nicol AF, Nuovo GJ, RT in situ PCR: Protocols and Applications in Methods in Microbiology. Volume 34. Edited by Tor Savidge, Charalabos P. Elsevier Acad Press; 2005Nicol AF, Nuovo GJ, Wang Y, Grinsztejn B, Tristao A, Russomano F, Perez MA, Lapa e Silva JR, Fernandes AT, Gage JR, Martinez-Maza O, Bonecini-Almeida MG: In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women. Exp Mol Pathol 2006, 81(1):42-7.Moberg M, Gustavsson I, Gyllensten U: Type-specific associations of human papillomavirus load with risk of developing cervical carcinoma in situ. Int J Cancer 2004, 112:854-859.Tjalma WA, Arbyan M, Paavonen J, van Waes TR, Bogers JJ: Prophylactic human papillomavirus vaccines: the beginning of the end of cervical cancer. Int J Gynecol Cancer 2004, 14:751-761.Estable MC, Bell B, Merzouki A, Montaner JS, O'Shaughnessy MV, Sadowski IJ: Human immunodeficiency virus type 1 long terminal repeat variants from 42 patients representing all stages of infection display a wide range of sequence polymorphism and transcription activity. J Virol 1996, 70(6):4053-62.Goff BA, Sallin J, Garcia R, VanBlaricom A, Paley PJ, Muntz HG: Evaluation of p27 in preinvasive and invasive malignancies of the cervix. Gynecol Oncol 2003, 88(1):40-4.Shiozawa T, Shiohara S, Kanai M, Konishi I, Fujii S, Nikaido T: Expression of the cell cycle regulator p27(Kip1) in normal squamous epithelium, cervical intraepithelial neoplasia, and invasive squamous cell carcinoma of the uterine cervix. Immunohistochemistry and functional aspects of p27(Kip1). Cancer 2001, 92(12):3005-11.Clarke B, Chetty R: Cell cycle aberrations in the pathogenesis of squamous cell carcinoma of the uterine cervix. Gynecol Oncol 2001, 82(2):238-46.Nam EJ, Kim JW, Kim SW, Kim YT, Kim JH, Yoon BS, Cho NH, Kim S: The expressions of the Rb pathway in cervical intraepithelial neoplasia; predictive and prognostic significance. Gynecol Oncol 2007, 104(1):207-11.Tringler B, Gup CJ, Singh M, Groshong S, Shroyer AL, Heinz DA, Shroyer KR: Evaluation of p16INK4A and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol 2004, 35(6):689-696.Stiegler P, Kasten M, Giordano A: The RB family of cell cycle regulatory factors. J Cell Biochem Suppl 1998, 31:30-6.De Falco G, Bellan C, Lazzi S, Claudio P, La Sala D, Cinti C, Tosi P, Giordano A, Leoncini L: Interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in the pathogenesis of AIDS-related neoplasms. 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dc.title.pt_BR.fl_str_mv Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA)
title Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA)
spellingShingle Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA)
Nicol, Alcina F.
Colo do Útero
Papillomavirus Humano 11
Infecções por HIV - transmissão
Infecções por HIV - diagnóstico
title_short Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA)
title_full Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA)
title_fullStr Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA)
title_full_unstemmed Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA)
title_sort Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA)
author Nicol, Alcina F.
author_facet Nicol, Alcina F.
Rodrigues Cordovil Pires, Andréa
de Souza, Simone R.
Nuovo, Gerard J.
Grinsztejn, Beatriz
Tristão, Aparecida
Russomano, Fábio Bastos
Velasque, Luciane
Lapa e Silva, José R.
Pirmez, Claude
author_role author
author2 Rodrigues Cordovil Pires, Andréa
de Souza, Simone R.
Nuovo, Gerard J.
Grinsztejn, Beatriz
Tristão, Aparecida
Russomano, Fábio Bastos
Velasque, Luciane
Lapa e Silva, José R.
Pirmez, Claude
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nicol, Alcina F.
Rodrigues Cordovil Pires, Andréa
de Souza, Simone R.
Nuovo, Gerard J.
Grinsztejn, Beatriz
Tristão, Aparecida
Russomano, Fábio Bastos
Velasque, Luciane
Lapa e Silva, José R.
Pirmez, Claude
dc.subject.decs.pt_BR.fl_str_mv Colo do Útero
Papillomavirus Humano 11
Infecções por HIV - transmissão
Infecções por HIV - diagnóstico
topic Colo do Útero
Papillomavirus Humano 11
Infecções por HIV - transmissão
Infecções por HIV - diagnóstico
description PN-DST/AIDS-MS-UNESCO, FAPERJ e IOC-FIOCRUZ
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-02-20T14:24:07Z
dc.date.available.fl_str_mv 2014-02-20T14:24:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NICOL, Alcina F. et al. Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA). BMC Cancer, London, v. 8, n. 289, p. 1-10, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7342
dc.identifier.issn.none.fl_str_mv 1471-2407
dc.identifier.doi.none.fl_str_mv 10.1186/1471-2407-8-289
identifier_str_mv NICOL, Alcina F. et al. Cell-cycle and suppressor proteins expression in uterine cervix in HIV/HPV co-infection: comparative study by tissue micro-array (TMA). BMC Cancer, London, v. 8, n. 289, p. 1-10, 2008.
1471-2407
10.1186/1471-2407-8-289
url https://www.arca.fiocruz.br/handle/icict/7342
dc.language.iso.fl_str_mv eng
language eng
dc.relation.isbasedon.pt_BR.fl_str_mv Tjalma W, van Waes T, van den Eeden L, Bogers J: Role of human papillomavirus in the carcinogenesis of squamous cell carcinoma and adenocarcinoma of the cervix. Best practice & Research Clin Obst Gynaecol 2005, 19(4):469-483.
Cho HN, Kim TY, Kim JW: Alteration of cell cycle in cervical tumor associated with Human Papillomavirus – Cyclin-Dependent kinase inhibitors. Yonsei Med J 2002, 43(6):722-728.
Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G: Inflammation and cancer: how hot is the link? Biochem Pharmacol 2006, 72(11):1605-21.
Branca M, Giorgi C, Santini D, Di Bonito L, Ciotti M, Benedetto A, Paba P, Costa S, Bonifacio D, Di Bonito P, Accardi L, Favalli C, Syrjanen K: Aberrant expression of VEGF-C is related to grade of cervical intraepithelial neoplasia (CIN) and high risk HPV, but does not predict virus clearance after treatment of CIN or prognosis of cervical cancer. J Clin Pathol 2006, 59(1):40-7.
Huang X, Brown C, Ni W, Maynard E, Rigby AC, Oetthen P: Critical role for the Ets transcription factor ELF-1 in the development of tumor angiogenesis. Blood 2006, 107(8):3153-3160.
Troncone G, Vetrani A, de Rosa G, Palombini L: Cyclin dependent kinase inhibitor p27 expression in normal and neoplastic cervical epithelium. J Clin Pathol 1999, 52:880-887.
Benevolo M, Mottolese M, Marandino F, Vocaturo G, Sindico R, Piperno G, Mariani L, Sperduti I, Canalini P, Donnorso RP, Vocaturo A: Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions. Mod Pathol 2006, 19(3):384-91.
Wentzensen N, von Knebel Doeberitz M: Biomarkers in cervical cancer screening. Dis Markers 2007, 23(4):315-30.
Nicol AF, Fernandes AT, Grinsztejn B, Russomano F, E Silva JR, Tristao A, Perez M, Nuovo GJ, Martinez-Maza O, Bonecini-Almeida M: Distribution of immune cell subsets and cytokine-producing cells in the uterine cervix of human papillomavirus (HPV)-infected women: influence of HIV-1 coinfection. Diagn Mol Pathol 2005, 14(1):39-47.
Nicol AF, Nuovo GJ, Salomão-Estevez A, Grinsztein B, Tristão A, Russomano F, Lapa E Silva JR, Oliveira MP, Pirmez C: Immune factors involved in the cervical immune response in the HIV/HPV co-infection. J Clin Pathol 2008, 61(1):84-8.
Gage JR, Sandhu AK, Nihira M, Bonecini-Almeida M da G, Cristoforoni P, Kishimoto T, Montz FJ, Martínez-Maza O: Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression. Obstet Gynecol 2000, 96(6):879-85.
Nyagol J, Leucci E, Onnis A, De Falco G, Tigli C, Sanseverino F, Torriccelli M, Palummo N, Pacenti L, Santopietro R, Spina D, Gichangi P, Muchiri L, Lazzi S, Petraglia F, Leoncini L, Giordano A: The effects of HIV-1 Tat protein on cell cycle during cervical carcinogenesis. Cancer Biol Ther 2006, 5(6):684-90.
Pires AR, da Matta Andreiuolo F, de Souza SR: TMA for all: a new method for the construction of tissue microarrays without recipient paraffin block using custom-built needles. Diagn Pathol 2006, 25(1):14.
Nicol AF, Nuovo GJ, RT in situ PCR: Protocols and Applications in Methods in Microbiology. Volume 34. Edited by Tor Savidge, Charalabos P. Elsevier Acad Press; 2005
Nicol AF, Nuovo GJ, Wang Y, Grinsztejn B, Tristao A, Russomano F, Perez MA, Lapa e Silva JR, Fernandes AT, Gage JR, Martinez-Maza O, Bonecini-Almeida MG: In situ detection of SOCS and cytokine expression in the uterine cervix from HIV/HPV coinfected women. Exp Mol Pathol 2006, 81(1):42-7.
Moberg M, Gustavsson I, Gyllensten U: Type-specific associations of human papillomavirus load with risk of developing cervical carcinoma in situ. Int J Cancer 2004, 112:854-859.
Tjalma WA, Arbyan M, Paavonen J, van Waes TR, Bogers JJ: Prophylactic human papillomavirus vaccines: the beginning of the end of cervical cancer. Int J Gynecol Cancer 2004, 14:751-761.
Estable MC, Bell B, Merzouki A, Montaner JS, O'Shaughnessy MV, Sadowski IJ: Human immunodeficiency virus type 1 long terminal repeat variants from 42 patients representing all stages of infection display a wide range of sequence polymorphism and transcription activity. J Virol 1996, 70(6):4053-62.
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