Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study

Bibliographic Details
Main Author: Gomes, André da Silva
Publication Date: 2023
Other Authors: Reis, Filipe Magno Pascoal, Ceravolo, Isabela Penna, Souza, Marcus Vinícius Dias
Format: Article
Language: por
Source: Repositório Institucional da FIOCRUZ (ARCA)
Download full: https://www.arca.fiocruz.br/handle/icict/57336
Summary: Oncohematology department. Oncobio Hospital. Belo Horizonte, MG, Brazil / Medical BSc Program. University Vale do Rio Doce. Governador Valadares, MG, Brazil.
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spelling Gomes, André da SilvaReis, Filipe Magno PascoalCeravolo, Isabela PennaSouza, Marcus Vinícius Dias2023-03-13T16:54:06Z2023-03-13T16:54:06Z2023GOMES, André da Silva et al. Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study. Biointerface Research in Applied Chemistry, v. 13, n. 2, p. 1-9, 2023.2069-5837https://www.arca.fiocruz.br/handle/icict/5733610.33263/BRIAC132.122porAMG Transcend AssociationEffectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOncohematology department. Oncobio Hospital. Belo Horizonte, MG, Brazil / Medical BSc Program. University Vale do Rio Doce. Governador Valadares, MG, Brazil.Medical BSc Program. University Vale do Rio Doce. Governador Valadares, MG, Brazil / Oswaldo Cruz Foundation. René Rachou Institute. Belo Horizonte, MG, Brazil.Oswaldo Cruz Foundation. René Rachou Institute. Belo Horizonte, MG, Brazil.Reference Center for Drug Information. Pitágoras College. Ipatinga, MG, Brazil.Hepatocellular carcinoma (HCC) is a highly prevalent form of liver cancer. Sorafenib is the first-line treatment for patients who are not eligible for surgical procedures. Still, it causes important adverse effects, does not provide symptoms relief, and is marketed at expensive costs. Here we investigated the effectiveness of imatinib, sunitinib, and bortezomib against an in vitro model of HCC. These drugs are less expensive than Sorafenib and are approved for other malignant neoplasia. The drugs were tested as free and liposome-entrapped forms against HepG2 cells. Liposomes were prepared without using organic solvents and were tested for physicochemical stability. Entrapment efficiency was determined by spectrophotometric methods. Liposomes' average size was 238±33 nm, with an average entrapment efficiency of 34.3%. All drugs significantly decreased the viability of HepG2 cells in their free form and liposome-entrapped forms compared to the control. In spite of the low entrapment efficiency, no organic solvent was used in liposomes preparation, and cell viability values after 18h treatments with liposome-entrapped drugs were only surpassed by the highest concentration of free drugs. Our data open doors for more studies to assess the safety of the liposomes in vivo.Anticancer drugsLiposomesHepG2 cellsHepatocellular carcinomainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57336/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEffectiveness of Free and Liposome-Entrapped Antitumoral Drugs against.pdfEffectiveness of Free and Liposome-Entrapped Antitumoral Drugs against.pdfapplication/pdf338793https://www.arca.fiocruz.br/bitstream/icict/57336/2/Effectiveness%20of%20Free%20and%20Liposome-Entrapped%20Antitumoral%20Drugs%20against.pdf2a4e99cd14aa04c1f3a3b72e11a5ad60MD52icict/573362023-06-13 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dc.title.en_US.fl_str_mv Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study
title Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study
spellingShingle Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study
Gomes, André da Silva
Anticancer drugs
Liposomes
HepG2 cells
Hepatocellular carcinoma
title_short Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study
title_full Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study
title_fullStr Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study
title_full_unstemmed Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study
title_sort Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study
author Gomes, André da Silva
author_facet Gomes, André da Silva
Reis, Filipe Magno Pascoal
Ceravolo, Isabela Penna
Souza, Marcus Vinícius Dias
author_role author
author2 Reis, Filipe Magno Pascoal
Ceravolo, Isabela Penna
Souza, Marcus Vinícius Dias
author2_role author
author
author
dc.contributor.author.fl_str_mv Gomes, André da Silva
Reis, Filipe Magno Pascoal
Ceravolo, Isabela Penna
Souza, Marcus Vinícius Dias
dc.subject.en.en_US.fl_str_mv Anticancer drugs
Liposomes
HepG2 cells
Hepatocellular carcinoma
topic Anticancer drugs
Liposomes
HepG2 cells
Hepatocellular carcinoma
description Oncohematology department. Oncobio Hospital. Belo Horizonte, MG, Brazil / Medical BSc Program. University Vale do Rio Doce. Governador Valadares, MG, Brazil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-13T16:54:06Z
dc.date.available.fl_str_mv 2023-03-13T16:54:06Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, André da Silva et al. Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study. Biointerface Research in Applied Chemistry, v. 13, n. 2, p. 1-9, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57336
dc.identifier.issn.en_US.fl_str_mv 2069-5837
dc.identifier.doi.none.fl_str_mv 10.33263/BRIAC132.122
identifier_str_mv GOMES, André da Silva et al. Effectiveness of Free and Liposome-Entrapped Antitumoral Drugs against Hepatocellular Carcinoma: A Comparative In vitro Study. Biointerface Research in Applied Chemistry, v. 13, n. 2, p. 1-9, 2023.
2069-5837
10.33263/BRIAC132.122
url https://www.arca.fiocruz.br/handle/icict/57336
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv AMG Transcend Association
publisher.none.fl_str_mv AMG Transcend Association
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57336/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57336/2/Effectiveness%20of%20Free%20and%20Liposome-Entrapped%20Antitumoral%20Drugs%20against.pdf
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bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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