Sand fly-Leishmania interactions: long relationships are not necessarily easy

Detalhes bibliográficos
Autor(a) principal: Ortigao, Marcelo Ramalho
Data de Publicação: 2010
Outros Autores: Saraiva, Elvira M., Traub-Csekö, Yara M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20973
Resumo: Kansas State University. Department o Entomology. Manhattan, KS, USA.
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spelling Ortigao, Marcelo RamalhoSaraiva, Elvira M.Traub-Csekö, Yara M.2017-09-12T16:26:37Z2017-09-12T16:26:37Z2010ORTIGÃO, Marcelo Ramalho; SARAIVA. Elvira M.; TRAUB-CSEKÖ, Yara M. Sand fly-Leishmania interactions: long relationships are not necessarily easy. The Open Parasitology Journal, v. 4, p. 195-204, Jan. 2010.1874-4214https://www.arca.fiocruz.br/handle/icict/2097310.2174/1874421401004010195engNational Institute of HealthPsychodidaeLeishmaniaTransmissãoPrevençãoManipulação genéticaSand fliesLeishmaniaPreventGenetic manipulationTransmissionSand fly-Leishmania interactions: long relationships are not necessarily easyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleKansas State University. Department o Entomology. Manhattan, KS, USA.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Parasitas e Vetores. Rio de Janeiro, RJ. Brasil.Sand fly and Leishmania are one of the best studied vector-parasite models. Much is known about the development of these parasites within the sand fly, and how transmission to a suitable vertebrate host takes place. Various molecules secreted by the vector assist the establishment of the infection in a vertebrate, and changes to the vector are promoted by the parasites in order to facilitate or enhance transmission. Despite a generally accepted view that sand flies and Leishmania are also one of the oldest vector-pathogen pairs known, such long history has not been translated into a harmonic relationship. Leishmania are faced with many barriers to the establishment of a successful infection within the sand fly vector, and specific associations have been developed which are thought to represent aspects of a co-evolution between the parasite and its vectors. In this review, we highlight the journey taken by Leishmania during its development within the vector, and describe the issues associated with the natural barriers encountered by the parasite. Recent data revealed sexual replication of Leishmania within the sand fly, but it is yet unknown if such reproduction affects disease outcome. New approaches targeting sand fly molecules to prevent parasite transmission are being sought, and various techniques related to genetic manipulation of sand flies are being utilized.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20973/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALyara_czeko_etal_IOC_2010.pdfyara_czeko_etal_IOC_2010.pdfapplication/pdf308385https://www.arca.fiocruz.br/bitstream/icict/20973/2/yara_czeko_etal_IOC_2010.pdfbc8d8e8a1043a77f1c1b041884002c2dMD52TEXTyara_czeko_etal_IOC_2010.pdf.txtyara_czeko_etal_IOC_2010.pdf.txtExtracted texttext/plain68361https://www.arca.fiocruz.br/bitstream/icict/20973/3/yara_czeko_etal_IOC_2010.pdf.txt7f07e25b87c24db547a34f33b5334b4eMD53icict/209732020-02-10 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dc.title.pt_BR.fl_str_mv Sand fly-Leishmania interactions: long relationships are not necessarily easy
title Sand fly-Leishmania interactions: long relationships are not necessarily easy
spellingShingle Sand fly-Leishmania interactions: long relationships are not necessarily easy
Ortigao, Marcelo Ramalho
Psychodidae
Leishmania
Transmissão
Prevenção
Manipulação genética
Sand flies
Leishmania
Prevent
Genetic manipulation
Transmission
title_short Sand fly-Leishmania interactions: long relationships are not necessarily easy
title_full Sand fly-Leishmania interactions: long relationships are not necessarily easy
title_fullStr Sand fly-Leishmania interactions: long relationships are not necessarily easy
title_full_unstemmed Sand fly-Leishmania interactions: long relationships are not necessarily easy
title_sort Sand fly-Leishmania interactions: long relationships are not necessarily easy
author Ortigao, Marcelo Ramalho
author_facet Ortigao, Marcelo Ramalho
Saraiva, Elvira M.
Traub-Csekö, Yara M.
author_role author
author2 Saraiva, Elvira M.
Traub-Csekö, Yara M.
author2_role author
author
dc.contributor.author.fl_str_mv Ortigao, Marcelo Ramalho
Saraiva, Elvira M.
Traub-Csekö, Yara M.
dc.subject.other.pt_BR.fl_str_mv Psychodidae
Leishmania
Transmissão
Prevenção
Manipulação genética
topic Psychodidae
Leishmania
Transmissão
Prevenção
Manipulação genética
Sand flies
Leishmania
Prevent
Genetic manipulation
Transmission
dc.subject.en.pt_BR.fl_str_mv Sand flies
Leishmania
Prevent
Genetic manipulation
Transmission
description Kansas State University. Department o Entomology. Manhattan, KS, USA.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2017-09-12T16:26:37Z
dc.date.available.fl_str_mv 2017-09-12T16:26:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ORTIGÃO, Marcelo Ramalho; SARAIVA. Elvira M.; TRAUB-CSEKÖ, Yara M. Sand fly-Leishmania interactions: long relationships are not necessarily easy. The Open Parasitology Journal, v. 4, p. 195-204, Jan. 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20973
dc.identifier.issn.pt_BR.fl_str_mv 1874-4214
dc.identifier.doi.none.fl_str_mv 10.2174/1874421401004010195
identifier_str_mv ORTIGÃO, Marcelo Ramalho; SARAIVA. Elvira M.; TRAUB-CSEKÖ, Yara M. Sand fly-Leishmania interactions: long relationships are not necessarily easy. The Open Parasitology Journal, v. 4, p. 195-204, Jan. 2010.
1874-4214
10.2174/1874421401004010195
url https://www.arca.fiocruz.br/handle/icict/20973
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv National Institute of Health
publisher.none.fl_str_mv National Institute of Health
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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