Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma

Detalhes bibliográficos
Autor(a) principal: Reis, Diego Carlos dos
Data de Publicação: 2019
Outros Autores: Damasceno, Karine Araújo, Campos, Cecília Bonolo de, Veloso, Emerson Soares, Pêgas, Gabriela Rafaela Arantes, Kraemer, Lucas Rocha, Rodrigues, Michele Angela, Mattos, Matheus Silvério, Gomes, Dawidson Assis, Campos, Paula Peixoto, Ferreira, Enio, Russo, Remo Castro, Cassali, Geovanni Dantas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36009
Resumo: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
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spelling Reis, Diego Carlos dosDamasceno, Karine AraújoCampos, Cecília Bonolo deVeloso, Emerson SoaresPêgas, Gabriela Rafaela ArantesKraemer, Lucas RochaRodrigues, Michele AngelaMattos, Matheus SilvérioGomes, Dawidson AssisCampos, Paula PeixotoFerreira, EnioRusso, Remo CastroCassali, Geovanni Dantas2019-09-30T16:50:18Z2019-09-30T16:50:18Z2019REIS, Diego Carlos dos et al. Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma. Frontiers in Oncology, v. 9, p. 1-14, July 2019.2234-943Xhttps://www.arca.fiocruz.br/handle/icict/3600910.3389/fonc.2019.00577Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of Biochemistry and Immunology. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Laboratory of Pulmonary Immunology and Mechanics. Department of Physiology and Biophysics. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Institute of Biological Sciences. Department of General Pathology. Belo Horizonte, MG, Brazil.Versican and tumor-associated macrophages (TAMs) are involved in growth and metastases in several cancers. Here, we investigated the potential role of versican, a matrix proteoglycan, and its correlation with TAMs infiltrates in different stages of two different breast cancer models: spontaneous canine mammary gland carcinomas and the murine 4T1 breast cancer model. The stromal versican expression was correlated with TAMs accumulation in tumors with an advanced stage from spontaneous canine mammary carcinoma samples. Versican expression in mice, identified in late stages of tumor progression, was associated to a high number of peri-tumoral infiltrating TAMs. Indeed, TAMs were related to a pro-inflammatory and pro-angiogenic state in the primary tumor. Furthermore, TAMs accumulation was related to versican expression in the lungs and an increased number of pulmonary metastatic nodules with pulmonary mechanical dysfunction, which was due to leukocyte influx in the airways and elevated growth factor levels in the microenvironment. Thus, we suggest that versican and TAMs as attractive targets for breast cancer therapy.engFrontiers MediaCâncer de mamaAngiogêneseMetástase pulmonarVersicanMacrófagos associados a tumoresBreast cancerAngiogenesisLung metastasisVersicanTumor-associated macrophagesVersican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/36009/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALReis, C. D. Versican....pdfReis, C. D. Versican....pdfapplication/pdf6212673https://www.arca.fiocruz.br/bitstream/icict/36009/2/Reis%2c%20C.%20D.%20Versican....pdff0e5f7d54df5fde4549844031d7af599MD52TEXTReis, C. D. 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dc.title.pt_BR.fl_str_mv Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
title Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
spellingShingle Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
Reis, Diego Carlos dos
Câncer de mama
Angiogênese
Metástase pulmonar
Versican
Macrófagos associados a tumores
Breast cancer
Angiogenesis
Lung metastasis
Versican
Tumor-associated macrophages
title_short Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
title_full Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
title_fullStr Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
title_full_unstemmed Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
title_sort Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma
author Reis, Diego Carlos dos
author_facet Reis, Diego Carlos dos
Damasceno, Karine Araújo
Campos, Cecília Bonolo de
Veloso, Emerson Soares
Pêgas, Gabriela Rafaela Arantes
Kraemer, Lucas Rocha
Rodrigues, Michele Angela
Mattos, Matheus Silvério
Gomes, Dawidson Assis
Campos, Paula Peixoto
Ferreira, Enio
Russo, Remo Castro
Cassali, Geovanni Dantas
author_role author
author2 Damasceno, Karine Araújo
Campos, Cecília Bonolo de
Veloso, Emerson Soares
Pêgas, Gabriela Rafaela Arantes
Kraemer, Lucas Rocha
Rodrigues, Michele Angela
Mattos, Matheus Silvério
Gomes, Dawidson Assis
Campos, Paula Peixoto
Ferreira, Enio
Russo, Remo Castro
Cassali, Geovanni Dantas
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Diego Carlos dos
Damasceno, Karine Araújo
Campos, Cecília Bonolo de
Veloso, Emerson Soares
Pêgas, Gabriela Rafaela Arantes
Kraemer, Lucas Rocha
Rodrigues, Michele Angela
Mattos, Matheus Silvério
Gomes, Dawidson Assis
Campos, Paula Peixoto
Ferreira, Enio
Russo, Remo Castro
Cassali, Geovanni Dantas
dc.subject.other.pt_BR.fl_str_mv Câncer de mama
Angiogênese
Metástase pulmonar
Versican
Macrófagos associados a tumores
topic Câncer de mama
Angiogênese
Metástase pulmonar
Versican
Macrófagos associados a tumores
Breast cancer
Angiogenesis
Lung metastasis
Versican
Tumor-associated macrophages
dc.subject.en.pt_BR.fl_str_mv Breast cancer
Angiogenesis
Lung metastasis
Versican
Tumor-associated macrophages
description Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-09-30T16:50:18Z
dc.date.available.fl_str_mv 2019-09-30T16:50:18Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv REIS, Diego Carlos dos et al. Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma. Frontiers in Oncology, v. 9, p. 1-14, July 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36009
dc.identifier.issn.pt_BR.fl_str_mv 2234-943X
dc.identifier.doi.none.fl_str_mv 10.3389/fonc.2019.00577
identifier_str_mv REIS, Diego Carlos dos et al. Versican and Tumor-Associated Macrophages Promotes Tumor Progression and Metastasis in Canine and Murine Models of Breast Carcinoma. Frontiers in Oncology, v. 9, p. 1-14, July 2019.
2234-943X
10.3389/fonc.2019.00577
url https://www.arca.fiocruz.br/handle/icict/36009
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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