Predictors of Viremia in Postpartum Women on Antiretroviral Therapy

Detalhes bibliográficos
Autor(a) principal: Hoffman, Risa M.
Data de Publicação: 2020
Outros Autores: Warshaw, Meredith G., Amico, K. Rivet, Pilotto, José, Masheto, Gaerolwe, Achalapong, Jullapong, Machado, Elizabeth, Chokephaibulkit, Kulkanya, Duarte, Geraldo, João, Esau, Graham, Kathleen K., Knapp, Katherine M., Stek, Alice M., Scott, Gwendolyn B., Coletti, Anne, Loftis, Amy J., Chakhtoura, Nahida, Currier, Judith S., PROMISE 1077HS Team
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43004
Resumo: Acesso aberto em 26/08/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898779/
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spelling Hoffman, Risa M.Warshaw, Meredith G.Amico, K. RivetPilotto, JoséMasheto, GaerolweAchalapong, JullapongMachado, ElizabethChokephaibulkit, KulkanyaDuarte, GeraldoJoão, EsauGraham, Kathleen K.Knapp, Katherine M.Stek, Alice M.Scott, Gwendolyn B.Coletti, AnneLoftis, Amy J.Chakhtoura, NahidaCurrier, Judith S.PROMISE 1077HS Team2020-08-26T20:01:31Z2020-08-26T20:01:31Z2020HOFFMAN, Risa M. et al. Predictors of Viremia in Postpartum Women on Antiretroviral Therapy. Journal of Acquired Immune Deficiency Syndromes, v. 83, n. 1, p. 72-80, Jan. 2020.1525-4135https://www.arca.fiocruz.br/handle/icict/4300410.1097/QAI.0000000000002228Acesso aberto em 26/08/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898779/Division of Infectious Diseases. David Geffen School of Medicine. University of California. Los Angeles, Los Angeles, CA, USA.Center for Biostatistics in AIDS Research. Harvard T.H. Chan School of Public Health. Boston, MA, USA.Health Behavior & Health Education. School of Public Health. University of Michigan. Ann Arbor, MI, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Botswana Harvard AIDS Institute Partnership. Gaborone, Botswana.Chiang Rai Prachanukroh Hospital. Chiang Rai, Thailand.Universidade Federal do Rio de Janeiro. Instituto de Puericultura e Pediatria Martagão. Rio de Janeiro, RJ, Brasil.Faculty of Medicine Siriraj Hospital. Mahidol University. Bangkok, Thailand.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil.Children’s Diagnostic and Treatment Center. Fort Lauderdale, FL, USA.Infectious Diseases Department. St Jude Children’s Research Hospital. Memphis, TN, USA.Department of Obstetrics and Gynecology. School of Medicine. University of Southern California. Los Angeles, CA, USA.School of Medicine. University of Miami Miller. Miami, FL, USA.FHI 360. Durham, NC, USA.Institute for Global Health and Infectious Diseases. University of North Carolina. Chapel Hill, NC, USA.Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) NIH. Bethesda, MD, USA.Division of Infectious Diseases. David Geffen School of Medicine. University of California Los Angeles, Los Angeles, CA, USA.PROMISE 1077HS TeamBackground: HIV-infected, postpartum women on antiretroviral therapy (ART) have high rates of viremia. We examined predictors of postpartum viremia in the PROMISE study. Methods: Women with pre-ART CD4+ T-cell counts $400 cells/mm3 who started ART during pregnancy were randomized postpartum to continue ART (CTART) or discontinue ART (DCART). Viral load and self-reported adherence were collected every 12 weeks, up to 144 weeks. Women in DCART reinitiated therapy when clinically indicated. Viremia was defined as 2 consecutive viral loads .1000 copies/mL after 24 weeks on ART. Adherence was dichotomized as missing versus not missing ART doses in the past 4 weeks. Predictors of viremia were examined using Cox proportional hazards regression with adherence as a time-varying covariate. Results: Among 802 women in the CTART arm, median age at entry was 27 years and median CD4+ T-cell count 696 cells/mm3. Of 175 women in CTART with viremia (22%), 141 had resistance data, and 12% had resistance to their current regimen. There was an estimated 0.12 probability of viremia by week 48 and 0.25 by week 144. Predictors of viremia included missed ART doses within the past 4 weeks, younger age, shorter duration of pre-entry ART, and being from the South American/Caribbean region. Of 137 women in DCART who reinitiated therapy, probability of viremia was similar to CTART (0.24 by week 96; 0.27 by week 144). Conclusions: Rates of postpartum viremia are high and viremia is more likely in younger postpartum women who start ART later in pregnancy. Interventions should target these higher-risk women.engWolters Kluwer Health, Inc.ViremiaTerapia antirretroviralMulheres pós-partoViremiaAntiretroviral TherapyPostpartum WomenPredictors of Viremia in Postpartum Women on Antiretroviral Therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43004/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJosePilotto_etal_IOC_2020.pdfJosePilotto_etal_IOC_2020.pdfapplication/pdf304586https://www.arca.fiocruz.br/bitstream/icict/43004/2/JosePilotto_etal_IOC_2020.pdf2194d79988cce538dbf13fa1338e47d4MD52TEXTJosePilotto_etal_IOC_2020.pdf.txtJosePilotto_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Predictors of Viremia in Postpartum Women on Antiretroviral Therapy
title Predictors of Viremia in Postpartum Women on Antiretroviral Therapy
spellingShingle Predictors of Viremia in Postpartum Women on Antiretroviral Therapy
Hoffman, Risa M.
Viremia
Terapia antirretroviral
Mulheres pós-parto
Viremia
Antiretroviral Therapy
Postpartum Women
title_short Predictors of Viremia in Postpartum Women on Antiretroviral Therapy
title_full Predictors of Viremia in Postpartum Women on Antiretroviral Therapy
title_fullStr Predictors of Viremia in Postpartum Women on Antiretroviral Therapy
title_full_unstemmed Predictors of Viremia in Postpartum Women on Antiretroviral Therapy
title_sort Predictors of Viremia in Postpartum Women on Antiretroviral Therapy
author Hoffman, Risa M.
author_facet Hoffman, Risa M.
Warshaw, Meredith G.
Amico, K. Rivet
Pilotto, José
Masheto, Gaerolwe
Achalapong, Jullapong
Machado, Elizabeth
Chokephaibulkit, Kulkanya
Duarte, Geraldo
João, Esau
Graham, Kathleen K.
Knapp, Katherine M.
Stek, Alice M.
Scott, Gwendolyn B.
Coletti, Anne
Loftis, Amy J.
Chakhtoura, Nahida
Currier, Judith S.
PROMISE 1077HS Team
author_role author
author2 Warshaw, Meredith G.
Amico, K. Rivet
Pilotto, José
Masheto, Gaerolwe
Achalapong, Jullapong
Machado, Elizabeth
Chokephaibulkit, Kulkanya
Duarte, Geraldo
João, Esau
Graham, Kathleen K.
Knapp, Katherine M.
Stek, Alice M.
Scott, Gwendolyn B.
Coletti, Anne
Loftis, Amy J.
Chakhtoura, Nahida
Currier, Judith S.
PROMISE 1077HS Team
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hoffman, Risa M.
Warshaw, Meredith G.
Amico, K. Rivet
Pilotto, José
Masheto, Gaerolwe
Achalapong, Jullapong
Machado, Elizabeth
Chokephaibulkit, Kulkanya
Duarte, Geraldo
João, Esau
Graham, Kathleen K.
Knapp, Katherine M.
Stek, Alice M.
Scott, Gwendolyn B.
Coletti, Anne
Loftis, Amy J.
Chakhtoura, Nahida
Currier, Judith S.
PROMISE 1077HS Team
dc.subject.other.pt_BR.fl_str_mv Viremia
Terapia antirretroviral
Mulheres pós-parto
topic Viremia
Terapia antirretroviral
Mulheres pós-parto
Viremia
Antiretroviral Therapy
Postpartum Women
dc.subject.en.pt_BR.fl_str_mv Viremia
Antiretroviral Therapy
Postpartum Women
description Acesso aberto em 26/08/2020 - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898779/
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-08-26T20:01:31Z
dc.date.available.fl_str_mv 2020-08-26T20:01:31Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv HOFFMAN, Risa M. et al. Predictors of Viremia in Postpartum Women on Antiretroviral Therapy. Journal of Acquired Immune Deficiency Syndromes, v. 83, n. 1, p. 72-80, Jan. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43004
dc.identifier.issn.pt_BR.fl_str_mv 1525-4135
dc.identifier.doi.none.fl_str_mv 10.1097/QAI.0000000000002228
identifier_str_mv HOFFMAN, Risa M. et al. Predictors of Viremia in Postpartum Women on Antiretroviral Therapy. Journal of Acquired Immune Deficiency Syndromes, v. 83, n. 1, p. 72-80, Jan. 2020.
1525-4135
10.1097/QAI.0000000000002228
url https://www.arca.fiocruz.br/handle/icict/43004
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wolters Kluwer Health, Inc.
publisher.none.fl_str_mv Wolters Kluwer Health, Inc.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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