Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.

Detalhes bibliográficos
Autor(a) principal: Santos, Cleiton Silva
Data de Publicação: 2013
Outros Autores: Azevedo, Everton Cruz de, Soares, Luciane Marieta, Carvalho, Magda Oliveira Seixas, Santos, Andréia Carvalho dos, Chagas Júnior, Adenizar Delgado das, Silva, Caroline Luane Rabelo da, Chagas, Ursula Maira Russo, Reis, Mitermayer Galvão dos, Athanazio, Daniel Abensur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7485
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
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spelling Santos, Cleiton SilvaAzevedo, Everton Cruz deSoares, Luciane MarietaCarvalho, Magda Oliveira SeixasSantos, Andréia Carvalho dosChagas Júnior, Adenizar Delgado dasSilva, Caroline Luane Rabelo daChagas, Ursula Maira RussoReis, Mitermayer Galvão dosAthanazio, Daniel Abensur2014-04-02T16:46:48Z2014-04-02T16:46:48Z2013SANTOS, C. S. et al. Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis. Memórias do Instituto Oswaldo Cruz, v. 108, n. 4, p. 438-445, 2013.1678-8060https://www.arca.fiocruz.br/handle/icict/748510.1590/0074-0276108042013007engFiocruzIonic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilLeptospirosis in humans usually involves hypokalaemia and hypomagnesaemia and the putative mechanism underlying such ionic imbalances may be related to nitric oxide (NO) production. We previously demonstrated the correlation between serum levels of NO and the severity of renal disease in patients with severe leptospirosis. Methylene blue inhibits soluble guanylyl cyclase (downstream of the action of any NO synthase isoforms) and was recently reported to have beneficial effects on clinical and experimental sepsis. We investigated the occurrence of serum ionic changes in experimental leptospirosis at various time points (4, 8, 16 and 28 days) in a hamster model. We also determined the effect of methylene blue treatment when administered as an adjuvant therapy, combined with late initiation of standard antibiotic (ampicillin) treatment. Hypokalaemia was not reproduced in this model: all of the groups developed increased levels of serum potassium (K). Furthermore, hypermagnesaemia, rather than magnesium (Mg) depletion, was observed in this hamster model of acute infection. These findings may be associated with an accelerated progression to acute renal failure. Adjuvant treatment with methylene blue had no effect on survival or serum Mg and K levels during acute-phase leptospirosis in hamsters.LeptospirosisMethylene blueModelsAnimalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSantos CS Ionic imbalance....pdfSantos CS Ionic imbalance....pdfapplication/pdf1240492https://www.arca.fiocruz.br/bitstream/icict/7485/1/Santos%20CS%20Ionic%20imbalance....pdfb9e90bc390bddbd9df80fa7d38b08435MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7485/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSantos CS Ionic imbalance....pdf.txtSantos CS Ionic imbalance....pdf.txtExtracted texttext/plain41671https://www.arca.fiocruz.br/bitstream/icict/7485/5/Santos%20CS%20Ionic%20imbalance....pdf.txt7211cff269c8bc7111abeac44cfb67eeMD55THUMBNAILSantos CS Ionic imbalance....pdf.jpgSantos CS Ionic imbalance....pdf.jpgGenerated Thumbnailimage/jpeg2175https://www.arca.fiocruz.br/bitstream/icict/7485/4/Santos%20CS%20Ionic%20imbalance....pdf.jpg3d36de3c97568551b97175ef7b953a1bMD54icict/74852023-03-15 14:33:12.262oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.
title Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.
spellingShingle Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.
Santos, Cleiton Silva
Leptospirosis
Methylene blue
Models
Animal
title_short Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.
title_full Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.
title_fullStr Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.
title_full_unstemmed Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.
title_sort Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis.
author Santos, Cleiton Silva
author_facet Santos, Cleiton Silva
Azevedo, Everton Cruz de
Soares, Luciane Marieta
Carvalho, Magda Oliveira Seixas
Santos, Andréia Carvalho dos
Chagas Júnior, Adenizar Delgado das
Silva, Caroline Luane Rabelo da
Chagas, Ursula Maira Russo
Reis, Mitermayer Galvão dos
Athanazio, Daniel Abensur
author_role author
author2 Azevedo, Everton Cruz de
Soares, Luciane Marieta
Carvalho, Magda Oliveira Seixas
Santos, Andréia Carvalho dos
Chagas Júnior, Adenizar Delgado das
Silva, Caroline Luane Rabelo da
Chagas, Ursula Maira Russo
Reis, Mitermayer Galvão dos
Athanazio, Daniel Abensur
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santos, Cleiton Silva
Azevedo, Everton Cruz de
Soares, Luciane Marieta
Carvalho, Magda Oliveira Seixas
Santos, Andréia Carvalho dos
Chagas Júnior, Adenizar Delgado das
Silva, Caroline Luane Rabelo da
Chagas, Ursula Maira Russo
Reis, Mitermayer Galvão dos
Athanazio, Daniel Abensur
dc.subject.en.pt_BR.fl_str_mv Leptospirosis
Methylene blue
Models
Animal
topic Leptospirosis
Methylene blue
Models
Animal
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-04-02T16:46:48Z
dc.date.available.fl_str_mv 2014-04-02T16:46:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTOS, C. S. et al. Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis. Memórias do Instituto Oswaldo Cruz, v. 108, n. 4, p. 438-445, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7485
dc.identifier.issn.none.fl_str_mv 1678-8060
dc.identifier.doi.none.fl_str_mv 10.1590/0074-0276108042013007
identifier_str_mv SANTOS, C. S. et al. Ionic imbalance and lack of effect of adjuvant treatment with methylene blue in the hamster model of leptospirosis. Memórias do Instituto Oswaldo Cruz, v. 108, n. 4, p. 438-445, 2013.
1678-8060
10.1590/0074-0276108042013007
url https://www.arca.fiocruz.br/handle/icict/7485
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Fiocruz
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