Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS

Detalhes bibliográficos
Autor(a) principal: Gomes, S. A.
Data de Publicação: 2004
Outros Autores: Castro, L. de, Niel, C., Santos, E. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32872
Resumo: Liane de Castro. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Gomes, S. A.Castro, L. deNiel, C.Santos, E. A.2019-04-30T13:00:13Z2019-04-30T13:00:13Z2004GOMES, S. A. et al. Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS. Journal of Infection, v. 48, p. 102-108, 2004.0163-4453https://www.arca.fiocruz.br/handle/icict/3287210.1016/S0163-4453(03)00126-9Liane de Castro. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-04-30Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Sem afiliação.Sem afiliação.Sem afiliação.Objective. To study the genomic variations of a hepatitis B virus (HBV) isolate in a patient coinfected with human immunodeficiency virus type 1 (HIV-1) who developed severe hepatitis and died of AIDS. Methods. Two blood samples were collected, the first one during the asymptomatic phase of HIV-1 infection, and the other, 3 years later, few months before the death of the patient. Both samples were HBsAg and anti-HBe positive. Pre-S/S and precore-core genome regions were PCR amplified and analyzed. Results. The HBV isolate belonged to genotype F, cluster IV. A number of unique amino acid substitutions were found in the surface antigen gene and the overlapping polymerase coding region of HBV genomes derived from both samples. However, these substitutions reflected natural variations rather than mutations of clinical significance. The precore stop codon mutation A1896 was present in both genomes. Furthermore, the HBV genome derived from the second, but not first sample, showed two out-of-frame core interval deletions, one and 103 nucleotides in length, respectively. Conclusions. This is the first report of an HBV isolate from genotype F with core internal deletions. Our results suggest an association between specific core mutations and the severe hepatitis developed by the patient.engElsevierUncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAIDSCore internal deletionGenotype FHepatitis B virusPrecore stop mutationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/32872/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Gomes_S_A_etal_INI_2004.pdfve_Gomes_S_A_etal_INI_2004.pdfapplication/pdf290673https://www.arca.fiocruz.br/bitstream/icict/32872/2/ve_Gomes_S_A_etal_INI_2004.pdff0081c161652f5ecb1e804f8e583c3feMD52TEXTve_Gomes_S_A_etal_INI_2004.pdf.txtve_Gomes_S_A_etal_INI_2004.pdf.txtExtracted texttext/plain25494https://www.arca.fiocruz.br/bitstream/icict/32872/3/ve_Gomes_S_A_etal_INI_2004.pdf.txt595c70595ef144b97dd7ee4676ffe537MD53icict/328722021-03-24 16:32:31.17oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS
title Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS
spellingShingle Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS
Gomes, S. A.
AIDS
Core internal deletion
Genotype F
Hepatitis B virus
Precore stop mutation
title_short Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS
title_full Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS
title_fullStr Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS
title_full_unstemmed Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS
title_sort Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS
author Gomes, S. A.
author_facet Gomes, S. A.
Castro, L. de
Niel, C.
Santos, E. A.
author_role author
author2 Castro, L. de
Niel, C.
Santos, E. A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Gomes, S. A.
Castro, L. de
Niel, C.
Santos, E. A.
dc.subject.en.pt_BR.fl_str_mv AIDS
Core internal deletion
Genotype F
Hepatitis B virus
Precore stop mutation
topic AIDS
Core internal deletion
Genotype F
Hepatitis B virus
Precore stop mutation
description Liane de Castro. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2019-04-30T13:00:13Z
dc.date.available.fl_str_mv 2019-04-30T13:00:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, S. A. et al. Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS. Journal of Infection, v. 48, p. 102-108, 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32872
dc.identifier.issn.pt_BR.fl_str_mv 0163-4453
dc.identifier.doi.none.fl_str_mv 10.1016/S0163-4453(03)00126-9
identifier_str_mv GOMES, S. A. et al. Uncommon mutation pattern of a hepatitis B virus isolate from genotype F infecting a patient with AIDS. Journal of Infection, v. 48, p. 102-108, 2004.
0163-4453
10.1016/S0163-4453(03)00126-9
url https://www.arca.fiocruz.br/handle/icict/32872
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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