The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.

Detalhes bibliográficos
Autor(a) principal: Magalhães-Gama, Fábio
Data de Publicação: 2022
Outros Autores: Alves-Hanna, Fabíola Silva, Araújo, Nilberto Dias, Barros, Mateus Souza, Silva, Flavio Souza, Catão, Claudio Lucas Santos, Moraes, Júlia Santos, Freitas, Izabela Cabral, Tarragô, Andréa Monteiro, Malheiro, Adriana, Carvalho, Andréa Teixeira de, Costa, Allyson Guimarães
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56314
Resumo: Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil.
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spelling Magalhães-Gama, FábioAlves-Hanna, Fabíola SilvaAraújo, Nilberto DiasBarros, Mateus SouzaSilva, Flavio SouzaCatão, Claudio Lucas SantosMoraes, Júlia SantosFreitas, Izabela CabralTarragô, Andréa MonteiroMalheiro, AdrianaCarvalho, Andréa Teixeira deCosta, Allyson Guimarães2023-01-04T13:47:47Z2023-01-04T13:47:47Z2022MAGALHÃES-GAMA, Fábio et al. The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications. Front Immunol., v. 13, 1071188, 2022. doi: 10.3389/fimmu.2022.1071188.1664-3224https://www.arca.fiocruz.br/handle/icict/56314engFrontiers Research FoundationThe Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, BrazilFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, BrazilFundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte, MG, Brazil/ Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/ Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte, MG, Brazil/Universidade Federal do Amazonas. Instituto de Ciências Biológicas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Programa de Pós-Graduação em Ciências Aplicadas à Hematologia. Manaus, AM, Brazil/Universidade Federal do Amazonas. Escola de Enfermagem de Manaus. Manaus, AM, Brazil.The leukemic microenvironment has a high diversity of immune cells that are phenotypically and functionally distinct. However, our understanding of the biology, immunology, and clinical implications underlying these cells remains poorly investigated. Among the resident immune cells that can infiltrate the leukemic microenvironment are myeloid cells, which correspond to a heterogeneous cell group of the innate immune system. They encompass populations of neutrophils, macrophages, and myeloid-derived suppressor cells (MDSCs). These cells can be abundant in different tissues and, in the leukemic microenvironment, are associated with the clinical outcome of the patient, acting dichotomously to contribute to leukemic progression or stimulate antitumor immune responses. In this review, we detail the current evidence and the many mechanisms that indicate that the activation of different myeloid cell populations may contribute to immunosuppression, survival, or metastatic dissemination, as well as in immunosurveillance and stimulation of specific cytotoxic responses. Furthermore, we broadly discuss the interactions of tumor-associated neutrophils and macrophages (TANs and TAMs, respectively) and MDSCs in the leukemic microenvironment. Finally, we provide new perspectives on the potential of myeloid cell subpopulations as predictive biomarkers of therapeutical response, as well as potential targets in the chemoimmunotherapy of leukemias due to their dual Yin-Yang roles in leukemia.immune responseimmunotherapyleukemiamacrophagesmyeloid-derived suppressor cellsneutrophilstumor microenvironmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56314/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALThe Yin-Yang of myeloid cells in the leukemic microenvironment.pdfThe Yin-Yang of myeloid cells in the leukemic microenvironment.pdfapplication/pdf1379993https://www.arca.fiocruz.br/bitstream/icict/56314/2/The%20Yin-Yang%20of%20myeloid%20cells%20in%20the%20leukemic%20microenvironment.pdfd1af3176f2364d4d0afda98b18c65697MD52icict/563142023-01-04 10:47:48.388oai:www.arca.fiocruz.br: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ório 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dc.title.en_US.fl_str_mv The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.
title The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.
spellingShingle The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.
Magalhães-Gama, Fábio
immune response
immunotherapy
leukemia
macrophages
myeloid-derived suppressor cells
neutrophils
tumor microenvironment
title_short The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.
title_full The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.
title_fullStr The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.
title_full_unstemmed The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.
title_sort The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications.
author Magalhães-Gama, Fábio
author_facet Magalhães-Gama, Fábio
Alves-Hanna, Fabíola Silva
Araújo, Nilberto Dias
Barros, Mateus Souza
Silva, Flavio Souza
Catão, Claudio Lucas Santos
Moraes, Júlia Santos
Freitas, Izabela Cabral
Tarragô, Andréa Monteiro
Malheiro, Adriana
Carvalho, Andréa Teixeira de
Costa, Allyson Guimarães
author_role author
author2 Alves-Hanna, Fabíola Silva
Araújo, Nilberto Dias
Barros, Mateus Souza
Silva, Flavio Souza
Catão, Claudio Lucas Santos
Moraes, Júlia Santos
Freitas, Izabela Cabral
Tarragô, Andréa Monteiro
Malheiro, Adriana
Carvalho, Andréa Teixeira de
Costa, Allyson Guimarães
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Magalhães-Gama, Fábio
Alves-Hanna, Fabíola Silva
Araújo, Nilberto Dias
Barros, Mateus Souza
Silva, Flavio Souza
Catão, Claudio Lucas Santos
Moraes, Júlia Santos
Freitas, Izabela Cabral
Tarragô, Andréa Monteiro
Malheiro, Adriana
Carvalho, Andréa Teixeira de
Costa, Allyson Guimarães
dc.subject.en.en_US.fl_str_mv immune response
immunotherapy
leukemia
macrophages
myeloid-derived suppressor cells
neutrophils
tumor microenvironment
topic immune response
immunotherapy
leukemia
macrophages
myeloid-derived suppressor cells
neutrophils
tumor microenvironment
description Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Diretoria de Ensino e Pesquisa. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Ciências da Saúde. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-04T13:47:47Z
dc.date.available.fl_str_mv 2023-01-04T13:47:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MAGALHÃES-GAMA, Fábio et al. The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications. Front Immunol., v. 13, 1071188, 2022. doi: 10.3389/fimmu.2022.1071188.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56314
dc.identifier.issn.en_US.fl_str_mv 1664-3224
identifier_str_mv MAGALHÃES-GAMA, Fábio et al. The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications. Front Immunol., v. 13, 1071188, 2022. doi: 10.3389/fimmu.2022.1071188.
1664-3224
url https://www.arca.fiocruz.br/handle/icict/56314
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56314/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56314/2/The%20Yin-Yang%20of%20myeloid%20cells%20in%20the%20leukemic%20microenvironment.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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