Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues

Detalhes bibliográficos
Autor(a) principal: Fadul, Luiza Cavalcanti
Data de Publicação: 2016
Outros Autores: Silva, Mariana Trindade da, Freitas, Luiz Antonio Rodrigues de, Athanazio, Daniel Abensur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13026
Resumo: Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil
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spelling Fadul, Luiza CavalcantiSilva, Mariana Trindade daFreitas, Luiz Antonio Rodrigues deAthanazio, Daniel Abensur2016-03-04T17:32:06Z2016-03-04T17:32:06Z2016FADUL, L. C. et al. Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues. Pathology Reseach and Practice, v. 212, n. 3, p. 217-221, 20160344-0338https://www.arca.fiocruz.br/handle/icict/13026dx.doi.org/10.1016/j.prp.2015.12.014engElsevierAssessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissuesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina. Departamento de Patologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Departamento de Patologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Imagepat. Pathology Laboratory. Salvador, BA, BrasilImagepat. Pathology Laboratory. Salvador, BA, BrasilBackground: Recent data suggest that up to 21% of positive circumferential margins (PCM) and 47% of extraprostatic extension (EPE) samples may be missed when partial embedding methods are employed. Kim and colleagues (2009) suggested that total inclusion of the periphery (3 mm rim) of the prostate prevented the failure to detect PCM and EPE. Design: Radical prostatectomy specimen (n = 148) slides were reviewed after adoption of a protocol that included a ∼3 mm rim of peripheral tissues. We evaluated whether the analysis of supplemental slides of prostate periphery changed margin status, presence of EPE, Gleason score and extent of PCM and EPE. Results: Partial sampling resulted in missing 29% of PCM and 20% of EPE without using data from the supplemental slides of prostate periphery. Changes from focal to extensive disease were found in 11/21 (52%) cases of positive circumferential margins and in 5/13 (38%) cases of extraprostatic extension. Changes in the Gleason score were uncommon. Conclusions: These results indicate the importance of including all the prostate peripheral tissue for microscopic analysis when partial embedding methods are adoptedProstatic neoplasmsPathologyProstatectomyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13026/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFadul LC Assessment....pdfFadul LC Assessment....pdfapplication/pdf797985https://www.arca.fiocruz.br/bitstream/icict/13026/2/Fadul%20LC%20Assessment....pdf882462a7ccd3cd3145f410f39ac1cd39MD52TEXTFadul LC Assessment....pdf.txtFadul LC Assessment....pdf.txtExtracted texttext/plain33125https://www.arca.fiocruz.br/bitstream/icict/13026/3/Fadul%20LC%20Assessment....pdf.txtbe3eb80e38242fb5b8407c083015e5a5MD53icict/130262023-03-15 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dc.title.pt_BR.fl_str_mv Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues
title Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues
spellingShingle Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues
Fadul, Luiza Cavalcanti
Prostatic neoplasms
Pathology
Prostatectomy
title_short Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues
title_full Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues
title_fullStr Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues
title_full_unstemmed Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues
title_sort Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues
author Fadul, Luiza Cavalcanti
author_facet Fadul, Luiza Cavalcanti
Silva, Mariana Trindade da
Freitas, Luiz Antonio Rodrigues de
Athanazio, Daniel Abensur
author_role author
author2 Silva, Mariana Trindade da
Freitas, Luiz Antonio Rodrigues de
Athanazio, Daniel Abensur
author2_role author
author
author
dc.contributor.author.fl_str_mv Fadul, Luiza Cavalcanti
Silva, Mariana Trindade da
Freitas, Luiz Antonio Rodrigues de
Athanazio, Daniel Abensur
dc.subject.en.pt_BR.fl_str_mv Prostatic neoplasms
Pathology
Prostatectomy
topic Prostatic neoplasms
Pathology
Prostatectomy
description Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Salvador, BA, Brasil
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-03-04T17:32:06Z
dc.date.available.fl_str_mv 2016-03-04T17:32:06Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FADUL, L. C. et al. Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues. Pathology Reseach and Practice, v. 212, n. 3, p. 217-221, 2016
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13026
dc.identifier.issn.none.fl_str_mv 0344-0338
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1016/j.prp.2015.12.014
identifier_str_mv FADUL, L. C. et al. Assessment of the circumferential margins, extraprostatic extension and Gleason score in radical prostatectomy specimens: Comparison of a partial embedding method with supplemental total inclusion of peripheral tissues. Pathology Reseach and Practice, v. 212, n. 3, p. 217-221, 2016
0344-0338
dx.doi.org/10.1016/j.prp.2015.12.014
url https://www.arca.fiocruz.br/handle/icict/13026
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/13026/1/license.txt
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