Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.

Detalhes bibliográficos
Autor(a) principal: Iani, Felipe Campos de Melo
Data de Publicação: 2016
Outros Autores: Caldas, Sérgio, Duarte, Myrian Morato, Cury, Ana Luisa Furtado, Cecílio, Alzira Batista, Costa, Pedro Augusto Carvalho, Antonelli, Lis Ribeiro do Valle, Gollob, Kenneth J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20111
Resumo: 2020-01-01
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spelling Iani, Felipe Campos de MeloCaldas, SérgioDuarte, Myrian MoratoCury, Ana Luisa FurtadoCecílio, Alzira BatistaCosta, Pedro Augusto CarvalhoAntonelli, Lis Ribeiro do ValleGollob, Kenneth J.2017-07-17T17:46:43Z2017-07-17T17:46:43Z2016IANI, Felipe Campos de Melo et al. Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8. Am J Trop Med Hyg., v. 95, n. 1, p. 193–200, 2016.0002-9637https://www.arca.fiocruz.br/handle/icict/2011110.4269/ajtmh.15-0537engAmerican Society of Tropical Medicine and HygieneDengueDengueDengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Fundação Ezequiel Dias. Instituto Octávio Magalhães. Divisão de Epidemiologia e Controle de Doenças. Belo Horizonte, MG, Brazil/Hospital Santa Casa. Instituto de Ensino e Pesquisa. Programa de Pós-graduação em Medicina e Biomedicina. Belo Horizonte, MG, Brazil.Fundação Ezequiel Dias. Diretoria de Pesquisa e Desenvolvimento. Divisão de Plataformas Tecnológicas. Belo Horizonte, MG, Brazil.Fundação Ezequiel Dias. Instituto Octávio Magalhães. Divisão de Epidemiologia e Controle de Doenças. Belo Horizonte, MG, BrazilFundação Ezequiel Dias. Instituto Octávio Magalhães. Divisão de Epidemiologia e Controle de Doenças. Belo Horizonte, MG, BrazilFundação Ezequiel Dias. Diretoria de Pesquisa e Desenvolvimento. Divisão de Plataformas Tecnológicas. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.Hospital Santa Casa. Instituto de Ensino e Pesquisa. Programa de Pós-graduação em Medicina e Biomedicina. Belo Horizonte, MG, Brazil/Institutos Nacionais de Ciências e Tecnologia-Doenças Tropicais. Belo Horizonte, MG, BrazilDengue is responsible for a wide range of clinical manifestations, ranging from asymptomatic infections to severe cases. The alteration of cytokine levels correlated with clinical characteristics can help determine prognostic markers of the disease and the identification of targets for immunotherapy. We measured the viral load, serotype, and cytokine levels of 212 serum samples from patients with acute dengue infection during days 1–4 after the onset of symptoms. The patients were classified as either with hemorrhagic manifestations (HM) or with no hemorrhagic manifestations (NHM). The cytokines interleukin-6 (IL-6), IL-8, and IL-10 were increased (P < 0.05) in the dengue virus+ group, compared with the control group. A higher viral load (P < 0.05) and IL-6 was detected in the HM group compared with the NHM group. Interestingly, the NHM group demonstrated a significant positive correlation between inflammatory (IL-6 and 8) and anti-inflammatory (IL-10) cytokines, whereas the HM group did not. These findings suggest that a disturbance in the balance of inflammatory cytokines IL-6 and IL-8 with the anti-inflammatory cytokine, IL-10, combined with the high levels of IL-6 and viral load, characterize possible mechanisms related to the formation of HM.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/20111/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALIani_Felipe_Dengue Patients_IRR_2016.pdfIani_Felipe_Dengue Patients_IRR_2016.pdfapplication/pdf6083224https://www.arca.fiocruz.br/bitstream/icict/20111/2/Iani_Felipe_Dengue%20Patients_IRR_2016.pdfabe074d3104d1e178ab8c1aacc7f3e45MD52TEXTIani_Felipe_Dengue Patients_IRR_2016.pdf.txtIani_Felipe_Dengue Patients_IRR_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.
title Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.
spellingShingle Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.
Iani, Felipe Campos de Melo
Dengue
Dengue
title_short Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.
title_full Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.
title_fullStr Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.
title_full_unstemmed Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.
title_sort Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8.
author Iani, Felipe Campos de Melo
author_facet Iani, Felipe Campos de Melo
Caldas, Sérgio
Duarte, Myrian Morato
Cury, Ana Luisa Furtado
Cecílio, Alzira Batista
Costa, Pedro Augusto Carvalho
Antonelli, Lis Ribeiro do Valle
Gollob, Kenneth J.
author_role author
author2 Caldas, Sérgio
Duarte, Myrian Morato
Cury, Ana Luisa Furtado
Cecílio, Alzira Batista
Costa, Pedro Augusto Carvalho
Antonelli, Lis Ribeiro do Valle
Gollob, Kenneth J.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Iani, Felipe Campos de Melo
Caldas, Sérgio
Duarte, Myrian Morato
Cury, Ana Luisa Furtado
Cecílio, Alzira Batista
Costa, Pedro Augusto Carvalho
Antonelli, Lis Ribeiro do Valle
Gollob, Kenneth J.
dc.subject.other.pt_BR.fl_str_mv Dengue
topic Dengue
Dengue
dc.subject.en.pt_BR.fl_str_mv Dengue
description 2020-01-01
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-07-17T17:46:43Z
dc.date.available.fl_str_mv 2017-07-17T17:46:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv IANI, Felipe Campos de Melo et al. Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8. Am J Trop Med Hyg., v. 95, n. 1, p. 193–200, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20111
dc.identifier.issn.pt_BR.fl_str_mv 0002-9637
dc.identifier.doi.none.fl_str_mv 10.4269/ajtmh.15-0537
identifier_str_mv IANI, Felipe Campos de Melo et al. Dengue Patients with Early Hemorrhagic Manifestations Lose Coordinate Expression of the Anti-Inflammatory Cytokine IL-10 with the Inflammatory Cytokines IL-6 and IL-8. Am J Trop Med Hyg., v. 95, n. 1, p. 193–200, 2016.
0002-9637
10.4269/ajtmh.15-0537
url https://www.arca.fiocruz.br/handle/icict/20111
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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