Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria

Detalhes bibliográficos
Autor(a) principal: Kayano, Ana Carolina A. V.
Data de Publicação: 2016
Outros Autores: Santos, João Conrado K. dos, Bastos, Marcele F., Carvalho, Leonardo J., Aliberti, Júlio, Costa, Fabio T. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16570
Resumo: Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução e Bioagentes. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.
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spelling Kayano, Ana Carolina A. V.Santos, João Conrado K. dosBastos, Marcele F.Carvalho, Leonardo J.Aliberti, JúlioCosta, Fabio T. M.2016-12-27T11:29:02Z2016-12-27T11:29:02Z2016KAYANO, Ana Carolina A. V. et al. Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria. Infection and Immunity, v.84, n.4, p.874-882, Apr. 2016.0019-9567https://www.arca.fiocruz.br/handle/icict/1657010.1128/IAI.01404-151098-5522engAmerican Society for MicrobiologyMaláriaMecanismos FisiopatológicosTerapias gasosassevere malariaPathophysiological MechanismsGaseous TherapiesPathophysiological Mechanisms in Gaseous Therapies for Severe Malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução e Bioagentes. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução e Bioagentes. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução e Bioagentes. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil.Cincinnati Children’s Hospital Medical Center., Cincinnati, Ohio, USA.Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução e Bioagentes. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.Over 200 million people worldwide suffer from malaria every year, a disease that causes 584,000 deaths annually. In recent years, significant improvements have been achieved on the treatment of severe malaria, with intravenous artesunate proving superior to quinine. However, mortality remains high, at 8% in children and 15% in adults in clinical trials, and even worse in the case of cerebral malaria (18% and 30%, respectively). Moreover, some individuals who do not succumb to severe malaria present long-term cognitive deficits. These observations indicate that strategies focused only on parasite killing fail to prevent neurological complications and deaths associated with severe malaria, possibly because clinical complications are associated in part with a cerebrovascular dysfunction. Consequently, different adjunctive therapies aimed at modulating malaria pathophysiological processes are currently being tested. However, none of these therapies has shown unequivocal evidence in improving patient clinical status. Recently, key studies have shown that gaseous therapies based mainly on nitric oxide (NO), carbon monoxide (CO), and hyperbaric (pressurized) oxygen (HBO) alter vascular endothelium dysfunction and modulate the host immune response to infection. Considering gaseous administration as a promising adjunctive treatment against severe malaria cases, we review here the pathophysiological mechanisms and the immunological aspects of such therapies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16570/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALleonardo_carvalho_etal_IOC_2016.pdfleonardo_carvalho_etal_IOC_2016.pdfapplication/pdf1207586https://www.arca.fiocruz.br/bitstream/icict/16570/2/leonardo_carvalho_etal_IOC_2016.pdf314acb5db8bb66635cd7a83d22478e37MD52TEXTleonardo_carvalho_etal_IOC_2016.pdf.txtleonardo_carvalho_etal_IOC_2016.pdf.txtExtracted texttext/plain59018https://www.arca.fiocruz.br/bitstream/icict/16570/3/leonardo_carvalho_etal_IOC_2016.pdf.txtf08824360b6abef097e566595344b991MD53icict/165702018-08-15 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dc.title.pt_BR.fl_str_mv Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria
title Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria
spellingShingle Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria
Kayano, Ana Carolina A. V.
Malária
Mecanismos Fisiopatológicos
Terapias gasosas
severe malaria
Pathophysiological Mechanisms
Gaseous Therapies
title_short Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria
title_full Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria
title_fullStr Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria
title_full_unstemmed Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria
title_sort Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria
author Kayano, Ana Carolina A. V.
author_facet Kayano, Ana Carolina A. V.
Santos, João Conrado K. dos
Bastos, Marcele F.
Carvalho, Leonardo J.
Aliberti, Júlio
Costa, Fabio T. M.
author_role author
author2 Santos, João Conrado K. dos
Bastos, Marcele F.
Carvalho, Leonardo J.
Aliberti, Júlio
Costa, Fabio T. M.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Kayano, Ana Carolina A. V.
Santos, João Conrado K. dos
Bastos, Marcele F.
Carvalho, Leonardo J.
Aliberti, Júlio
Costa, Fabio T. M.
dc.subject.other.pt_BR.fl_str_mv Malária
Mecanismos Fisiopatológicos
Terapias gasosas
topic Malária
Mecanismos Fisiopatológicos
Terapias gasosas
severe malaria
Pathophysiological Mechanisms
Gaseous Therapies
dc.subject.en.pt_BR.fl_str_mv severe malaria
Pathophysiological Mechanisms
Gaseous Therapies
description Universidade de Campinas. Instituto de Biologia. Departamento de Genética, Evolução e Bioagentes. Laboratório de Doenças Tropicais Prof. Dr. Luiz Jacintho da Silva. Campinas, SP, Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-27T11:29:02Z
dc.date.available.fl_str_mv 2016-12-27T11:29:02Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KAYANO, Ana Carolina A. V. et al. Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria. Infection and Immunity, v.84, n.4, p.874-882, Apr. 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16570
dc.identifier.issn.pt_BR.fl_str_mv 0019-9567
dc.identifier.doi.none.fl_str_mv 10.1128/IAI.01404-15
dc.identifier.eissn.none.fl_str_mv 1098-5522
identifier_str_mv KAYANO, Ana Carolina A. V. et al. Pathophysiological Mechanisms in Gaseous Therapies for Severe Malaria. Infection and Immunity, v.84, n.4, p.874-882, Apr. 2016.
0019-9567
10.1128/IAI.01404-15
1098-5522
url https://www.arca.fiocruz.br/handle/icict/16570
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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