Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population

Detalhes bibliográficos
Autor(a) principal: Grant, Audrey V
Data de Publicação: 2012
Outros Autores: Araujo, Maria Ilma Andrade Santos, Ponte, Eduardo Vieira, Oliveira, Ricardo Riccio, Gao, Peisong, Cruz Filho, Alvaro Augusto Souza da, Barnes, Kathleen C, Beaty, Terri H
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27330
Resumo: Oliveira, Ricardo Riccio. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
id CRUZ_98eb47380f81a089ef9fa4c447dcd227
oai_identifier_str oai:www.arca.fiocruz.br:icict/27330
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Grant, Audrey VAraujo, Maria Ilma Andrade SantosPonte, Eduardo VieiraOliveira, Ricardo RiccioGao, PeisongCruz Filho, Alvaro Augusto Souza daBarnes, Kathleen CBeaty, Terri H2018-07-05T18:08:03Z2018-07-05T18:08:03Z2012GRANT, A. V. et al. Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population. Plos One, v. 7, n. 5, p. e35863, 2012.1932-6203https://www.arca.fiocruz.br/handle/icict/2733010.1371/journal.pone.0035863Oliveira, Ricardo Riccio. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Glaxo-Smith-Kline under the project WE445 entitled ‘‘Immunogenetics of Schistosomiasis and Asthma,’’ and National Institutes of Health grant # AI050024. KCBThe Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of America / The Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of AmericaUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilFederal University of Bahia School of Medicine. Programa para o Controle da Asma e Rinite Alérgica na Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilThe Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of AmericaUniversidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Programa para o Controle da Asma e Rinite Alérgica na Bahia. Salvador, BA, BrasilThe Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of America / The Johns Hopkins University. Division of Allergy and Clinical Immunology. Department of Medicine. Baltimore, MD, United States of AmericaThe Johns Hopkins University. Bloomberg School of Public Health. Department of Epidemiology. Baltimore, MD, United States of AmericaIL-13 is a signature cytokine of the helper T cell type 2 (TH2) pathway which underlies host defense to helminthic infection and activates production of IgE in both parasitized populations and in urban settings after allergen exposure. Methodology/Principal Findings: Two functional polymorphisms in IL13, rs1800925 (or c.1-1111C.T) and rs20541 (or R130Q) were previously found to be associated with Schistosoma hematobium infection intensity. They have not been thoroughly explored in S. mansoni-endemic populations, however, and were selected along with 5 tagging SNPs for genotyping in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area of Conde, Bahia, in Brazil. Regression models using GEE to account for family membership and family-based quantitative transmission disequilibrium tests (QTDT) were used to evaluate associations with total serum IgE (tIgE) levels and S. mansoni fecal egg counts adjusted for non-genetic covariates. We identified a protective effect for the T allele at rs20541 (P = 0.005) against high S. mansoni egg counts, corroborated by QTDT (P = 0.014). Our findings also suggested evidence for protective effects for the T allele at rs1800925 and A allele at rs2066960 after GEE analysis only (P = 0.050, 0.0002). Conclusions/Significance: The two functional variants in IL13 are protective against high S. mansoni egg counts. These markers showed no evidence of association with tIgE levels, unlike tIgE levels previously studied in non-parasitized or atopic study populations.engPublic Library of SciencePolimorfismoSchistosoma mansoniPopulaçãoInfecçãoHumanosBrasilPolymorphismsSchistosoma mansoniPopulationsInfectionHumansBrazilFunctional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/27330/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGrant AV Functional Polymorphisms in IL13 Are Protective ....pdfGrant AV Functional Polymorphisms in IL13 Are Protective ....pdfapplication/pdf636555https://www.arca.fiocruz.br/bitstream/icict/27330/2/Grant%20AV%20Functional%20Polymorphisms%20in%20IL13%20Are%20Protective%20....pdf4b73961c2ce88455088f752041fd2945MD52TEXTGrant AV Functional Polymorphisms in IL13 Are Protective ....pdf.txtGrant AV Functional Polymorphisms in IL13 Are Protective ....pdf.txtExtracted texttext/plain36586https://www.arca.fiocruz.br/bitstream/icict/27330/3/Grant%20AV%20Functional%20Polymorphisms%20in%20IL13%20Are%20Protective%20....pdf.txtcce30e272688c41b19ac6e5634f66ef7MD53icict/273302023-03-15 14:34:13.646oai:www.arca.fiocruz.br:icict/27330Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:13Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population
title Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population
spellingShingle Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population
Grant, Audrey V
Polimorfismo
Schistosoma mansoni
População
Infecção
Humanos
Brasil
Polymorphisms
Schistosoma mansoni
Populations
Infection
Humans
Brazil
title_short Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population
title_full Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population
title_fullStr Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population
title_full_unstemmed Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population
title_sort Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population
author Grant, Audrey V
author_facet Grant, Audrey V
Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Gao, Peisong
Cruz Filho, Alvaro Augusto Souza da
Barnes, Kathleen C
Beaty, Terri H
author_role author
author2 Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Gao, Peisong
Cruz Filho, Alvaro Augusto Souza da
Barnes, Kathleen C
Beaty, Terri H
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Grant, Audrey V
Araujo, Maria Ilma Andrade Santos
Ponte, Eduardo Vieira
Oliveira, Ricardo Riccio
Gao, Peisong
Cruz Filho, Alvaro Augusto Souza da
Barnes, Kathleen C
Beaty, Terri H
dc.subject.other.pt_BR.fl_str_mv Polimorfismo
Schistosoma mansoni
População
Infecção
Humanos
Brasil
topic Polimorfismo
Schistosoma mansoni
População
Infecção
Humanos
Brasil
Polymorphisms
Schistosoma mansoni
Populations
Infection
Humans
Brazil
dc.subject.en.pt_BR.fl_str_mv Polymorphisms
Schistosoma mansoni
Populations
Infection
Humans
Brazil
description Oliveira, Ricardo Riccio. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2018-07-05T18:08:03Z
dc.date.available.fl_str_mv 2018-07-05T18:08:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GRANT, A. V. et al. Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population. Plos One, v. 7, n. 5, p. e35863, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27330
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0035863
identifier_str_mv GRANT, A. V. et al. Functional polymorphisms in IL13 are protective against high Schistosoma mansoni infection intensity in a Brazilian population. Plos One, v. 7, n. 5, p. e35863, 2012.
1932-6203
10.1371/journal.pone.0035863
url https://www.arca.fiocruz.br/handle/icict/27330
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/27330/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/27330/2/Grant%20AV%20Functional%20Polymorphisms%20in%20IL13%20Are%20Protective%20....pdf
https://www.arca.fiocruz.br/bitstream/icict/27330/3/Grant%20AV%20Functional%20Polymorphisms%20in%20IL13%20Are%20Protective%20....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
4b73961c2ce88455088f752041fd2945
cce30e272688c41b19ac6e5634f66ef7
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798325097547694080

Registros relacionados