Deciphering the Role Played by Autophagy in Leishmania Infection

Detalhes bibliográficos
Autor(a) principal: Veras, Patrícia Sampaio Tavares
Data de Publicação: 2019
Outros Autores: Menezes, Juliana Perrone Bezerra de, Dias, Beatriz Rocha Simões
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37788
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia (PV, http://www.fapesb.ba.gov.br), Conselho Nacional de Pesquisa e Desenvolvimento Científico (PV, http://www.cnpq.br). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal deNível Superior— Brasil (CAPES)—Finance Code 001. PV holds a grant fromCNPq for productivity in research (307832/2015-5).
id CRUZ_998e2f8cf6f12c5f5b1e7a21aae390ae
oai_identifier_str oai:www.arca.fiocruz.br:icict/37788
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Veras, Patrícia Sampaio TavaresMenezes, Juliana Perrone Bezerra deDias, Beatriz Rocha Simões2019-12-10T16:54:43Z2019-12-10T16:54:43Z2019VERAS, Patricia Sampaio Tavares; MENEZES, Juliana Perrone Bezerra de; DIAS, Beatriz Rocha Simões. Deciphering the role played by autophagy in Leishmania Infection. Frontiers in Immunology, v. 10, p. 1-11, Nov. 2019.1664-3224https://www.arca.fiocruz.br/handle/icict/3778810.3389/fimmu.2019.02523Fundação de Amparo à Pesquisa do Estado da Bahia (PV, http://www.fapesb.ba.gov.br), Conselho Nacional de Pesquisa e Desenvolvimento Científico (PV, http://www.cnpq.br). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal deNível Superior— Brasil (CAPES)—Finance Code 001. PV holds a grant fromCNPq for productivity in research (307832/2015-5).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório Parasito-Hospedeiro e Epidemiologia. Salvador, BA, Brasil / National Institute of Science and Technology of Tropical Diseases. Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Parasito-Hospedeiro e Epidemiologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Parasito-Hospedeiro e Epidemiologia. Salvador, BA, Brasil.In recent decades, studies have shown that, depending on parasite species and host background, autophagy can either favor infection or promote parasite clearance. To date, relatively few studies have attempted to assess the role played by autophagy in Leishmania infection. While it has been consistently shown that Leishmania spp. induce autophagy in a variety of cell types, published results regarding the effects of autophagic modulation on Leishmania survival are contradictory. The present review, after a short overview of the general aspects of autophagy, aims to summarize the current body of knowledge surrounding how Leishmania spp. adaptively interact with macrophages, the host cells mainly involved in controlling leishmaniasis. We then explore the scarce studies that have investigated interactions between these parasite species and the autophagic pathway, and finally present a critical perspective on how autophagy influences infection outcome.engFrontiers MediaAutofagiaLeishmaniaLC3MacrófagosFagocitoseLeishmanioseVacúolos parasitóforosAutophagyLeishmaniaLC3MacrophagesPhagocytosisLeishmaniasisParasitophorous vacuolesDeciphering the Role Played by Autophagy in Leishmania Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37788/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVeras, P.S.T. Deciphering....pdfVeras, P.S.T. Deciphering....pdfapplication/pdf2656851https://www.arca.fiocruz.br/bitstream/icict/37788/2/Veras%2c%20P.S.T.%20Deciphering....pdf47e32a3b983116aac9bbbfd38a5df64fMD52TEXTVeras, P.S.T. Deciphering....pdf.txtVeras, P.S.T. Deciphering....pdf.txtExtracted texttext/plain65671https://www.arca.fiocruz.br/bitstream/icict/37788/3/Veras%2c%20P.S.T.%20Deciphering....pdf.txt323bec221ab3686aa20bd7f97cd603fdMD53icict/377882023-03-15 14:34:17.139oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Deciphering the Role Played by Autophagy in Leishmania Infection
title Deciphering the Role Played by Autophagy in Leishmania Infection
spellingShingle Deciphering the Role Played by Autophagy in Leishmania Infection
Veras, Patrícia Sampaio Tavares
Autofagia
Leishmania
LC3
Macrófagos
Fagocitose
Leishmaniose
Vacúolos parasitóforos
Autophagy
Leishmania
LC3
Macrophages
Phagocytosis
Leishmaniasis
Parasitophorous vacuoles
title_short Deciphering the Role Played by Autophagy in Leishmania Infection
title_full Deciphering the Role Played by Autophagy in Leishmania Infection
title_fullStr Deciphering the Role Played by Autophagy in Leishmania Infection
title_full_unstemmed Deciphering the Role Played by Autophagy in Leishmania Infection
title_sort Deciphering the Role Played by Autophagy in Leishmania Infection
author Veras, Patrícia Sampaio Tavares
author_facet Veras, Patrícia Sampaio Tavares
Menezes, Juliana Perrone Bezerra de
Dias, Beatriz Rocha Simões
author_role author
author2 Menezes, Juliana Perrone Bezerra de
Dias, Beatriz Rocha Simões
author2_role author
author
dc.contributor.author.fl_str_mv Veras, Patrícia Sampaio Tavares
Menezes, Juliana Perrone Bezerra de
Dias, Beatriz Rocha Simões
dc.subject.other.pt_BR.fl_str_mv Autofagia
Leishmania
LC3
Macrófagos
Fagocitose
Leishmaniose
Vacúolos parasitóforos
topic Autofagia
Leishmania
LC3
Macrófagos
Fagocitose
Leishmaniose
Vacúolos parasitóforos
Autophagy
Leishmania
LC3
Macrophages
Phagocytosis
Leishmaniasis
Parasitophorous vacuoles
dc.subject.en.pt_BR.fl_str_mv Autophagy
Leishmania
LC3
Macrophages
Phagocytosis
Leishmaniasis
Parasitophorous vacuoles
description Fundação de Amparo à Pesquisa do Estado da Bahia (PV, http://www.fapesb.ba.gov.br), Conselho Nacional de Pesquisa e Desenvolvimento Científico (PV, http://www.cnpq.br). This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal deNível Superior— Brasil (CAPES)—Finance Code 001. PV holds a grant fromCNPq for productivity in research (307832/2015-5).
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-12-10T16:54:43Z
dc.date.available.fl_str_mv 2019-12-10T16:54:43Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VERAS, Patricia Sampaio Tavares; MENEZES, Juliana Perrone Bezerra de; DIAS, Beatriz Rocha Simões. Deciphering the role played by autophagy in Leishmania Infection. Frontiers in Immunology, v. 10, p. 1-11, Nov. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37788
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2019.02523
identifier_str_mv VERAS, Patricia Sampaio Tavares; MENEZES, Juliana Perrone Bezerra de; DIAS, Beatriz Rocha Simões. Deciphering the role played by autophagy in Leishmania Infection. Frontiers in Immunology, v. 10, p. 1-11, Nov. 2019.
1664-3224
10.3389/fimmu.2019.02523
url https://www.arca.fiocruz.br/handle/icict/37788
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/37788/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/37788/2/Veras%2c%20P.S.T.%20Deciphering....pdf
https://www.arca.fiocruz.br/bitstream/icict/37788/3/Veras%2c%20P.S.T.%20Deciphering....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
47e32a3b983116aac9bbbfd38a5df64f
323bec221ab3686aa20bd7f97cd603fd
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009188406689792

Registros relacionados