Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features

Detalhes bibliográficos
Autor(a) principal: Scheiner, Marcos A.
Data de Publicação: 2008
Outros Autores: Campos, Mercia M., Ornellas, Antonio A., Chin, Eduardo W., Ornellas, Maria H., Andrada-Serpa, Maria J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57910
Resumo: National Cancer Institute. Hematology Service. Rio de Janeiro, RJ, Brasil.
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spelling Scheiner, Marcos A.Campos, Mercia M.Ornellas, Antonio A.Chin, Eduardo W.Ornellas, Maria H.Andrada-Serpa, Maria J.2023-04-23T03:10:02Z2023-04-23T03:10:02Z2008SCHEINER, Marcos A. et al. Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features. International Brazilian Journal of Urology, v. 34, n. 4, p. 467-474, Jul./Aug. 2008.1677-5538https://www.arca.fiocruz.br/handle/icict/5791010.1590/S1677-553820080004000091677-6119engSociedade Brasileira de UrologiaHuman papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical featuresinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Cancer Institute. Hematology Service. Rio de Janeiro, RJ, Brasil.National Cancer Institute. Hematology Service. Rio de Janeiro, RJ, Brasil.National Cancer Institute. Section of Urology. Rio de Janeiro, RJ, Brasil.National Cancer Institute. Section of Urology. Rio de Janeiro, RJ, Brasil.National Cancer Institute. Bone Marrow Transplant Center. Rio de Janeiro, RJ, Brasil.Oswaldo Cruz Foundation. Evandro Chagas Institute of Clinical Research. Virology Service. Rio de Janeiro, RJ, Brazil.OBJECTIVE: To determine the prevalence of human papillomavirus (HPV) DNA in penile cancers in Rio de Janeiro, Brazil. MATERIALS AND METHODS: We studied, prospectively, 80 consecutive cases of patients with penile cancers who underwent surgical treatment at three different Hospitals in Rio de Janeiro between March 1995 and June 2000. Of these patients, 72 were diagnosed with invasive squamous cell carcinoma and 8 patients with verrucous carcinoma. The following parameters were observed: presence or absence of HPV DNA viral type, histological subtypes, clinical stage and overall survival. RESULTS: HPV DNA was detected in 75% of patients with invasive carcinomas and in 50% of patients with verrucous carcinomas. High risk HPVs were detected in 15 of 54 (27.8%) patients with HPV positive invasive tumors and in 1 of 4 (25%) patients with HPV positive verrucous tumors. HPV 16 was the most frequent type observed. No correlation was observed between HPV status and histological subtype (p = 0.51) as well as HPV status and stage stratification (p = 0.88). HPV status was also not significantly associated with the presence of regional metastases (p = 0.89). The overall survival was related to the presence of lymph node metastases (p < 0.0001). CONCLUSIONS: HPV infection may have contributed to malignant transformation in a large proportion of our penile cancer cases but only inguinal metastasis was a prognostic factor for survival in these patients with penile carcinoma.Human papillomavirusPenile cancerBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Scheiner_Marcos_etal_INI_2008.pdfve_Scheiner_Marcos_etal_INI_2008.pdfapplication/pdf171952https://www.arca.fiocruz.br/bitstream/icict/57910/2/ve_Scheiner_Marcos_etal_INI_2008.pdf34851f7a23d44506e6c010b834c20671MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57910/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/579102023-04-23 00:12:06.247oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-23T03:12:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features
title Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features
spellingShingle Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features
Scheiner, Marcos A.
Human papillomavirus
Penile cancer
Brazil
title_short Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features
title_full Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features
title_fullStr Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features
title_full_unstemmed Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features
title_sort Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features
author Scheiner, Marcos A.
author_facet Scheiner, Marcos A.
Campos, Mercia M.
Ornellas, Antonio A.
Chin, Eduardo W.
Ornellas, Maria H.
Andrada-Serpa, Maria J.
author_role author
author2 Campos, Mercia M.
Ornellas, Antonio A.
Chin, Eduardo W.
Ornellas, Maria H.
Andrada-Serpa, Maria J.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Scheiner, Marcos A.
Campos, Mercia M.
Ornellas, Antonio A.
Chin, Eduardo W.
Ornellas, Maria H.
Andrada-Serpa, Maria J.
dc.subject.en.en_US.fl_str_mv Human papillomavirus
Penile cancer
Brazil
topic Human papillomavirus
Penile cancer
Brazil
description National Cancer Institute. Hematology Service. Rio de Janeiro, RJ, Brasil.
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2023-04-23T03:10:02Z
dc.date.available.fl_str_mv 2023-04-23T03:10:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SCHEINER, Marcos A. et al. Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features. International Brazilian Journal of Urology, v. 34, n. 4, p. 467-474, Jul./Aug. 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57910
dc.identifier.issn.en_US.fl_str_mv 1677-5538
dc.identifier.doi.none.fl_str_mv 10.1590/S1677-55382008000400009
dc.identifier.eissn.none.fl_str_mv 1677-6119
identifier_str_mv SCHEINER, Marcos A. et al. Human papillomavirus and penile cancers in Rio de Janeiro, Brazil: HPV typing and clinical features. International Brazilian Journal of Urology, v. 34, n. 4, p. 467-474, Jul./Aug. 2008.
1677-5538
10.1590/S1677-55382008000400009
1677-6119
url https://www.arca.fiocruz.br/handle/icict/57910
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57910/2/ve_Scheiner_Marcos_etal_INI_2008.pdf
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