Structural and Molecular Modeling Features of P2X Receptors

Detalhes bibliográficos
Autor(a) principal: Alves, Luiz Anastácio
Data de Publicação: 2014
Outros Autores: Silva, João Hermínio Martins da, Ferreira, Dinarte Neto Moreira, Fidalgo Neto, Antonio Augusto, Teixeira, Pedro Celso Nogueira, Souza, Cristina Alves Magalhães de, Caffarena, Ernesto Raúl, Freitas, Mônica Santos de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10262
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
id CRUZ_99984476db006c36dd6bce344d3ca9e5
oai_identifier_str oai:www.arca.fiocruz.br:icict/10262
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Alves, Luiz AnastácioSilva, João Hermínio Martins daFerreira, Dinarte Neto MoreiraFidalgo Neto, Antonio AugustoTeixeira, Pedro Celso NogueiraSouza, Cristina Alves Magalhães deCaffarena, Ernesto RaúlFreitas, Mônica Santos de2015-05-08T14:08:45Z2015-05-08T14:08:45Z2014ALVES, Luiz Anastacio et al. Structural and Molecular Modeling Features of P2X Receptors. International Journal of Molecular Sciences, n.15, p.4531-4549, 2014.1422-0067https://www.arca.fiocruz.br/handle/icict/1026210.3390/ijms15034531engMDPIStructural and Molecular Modeling Features of P2X Receptorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Fortaleza, CE, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Currently, adenosine 5'-triphosphate (ATP) is recognized as the extracellular messenger that acts through P2 receptors. P2 receptors are divided into two subtypes: P2Y metabotropic receptors and P2X ionotropic receptors, both of which are found in virtually all mammalian cell types studied. Due to the difficulty in studying membrane protein structures by X-ray crystallography or NMR techniques, there is little information about these structures available in the literature. Two structures of the P2X4 receptor in truncated form have been solved by crystallography. Molecular modeling has proven to be an excellent tool for studying ionotropic receptors. Recently, modeling studies carried out on P2X receptors have advanced our knowledge of the P2X receptor structure-function relationships. This review presents a brief history of ion channel structural studies and shows how modeling approaches can be used to address relevant questions about P2X receptors.P2X7 receptorIon channel activityPatch-clampinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10262/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALpedro_teixeiraetal_IOC_2014.pdfapplication/pdf1170587https://www.arca.fiocruz.br/bitstream/icict/10262/2/pedro_teixeiraetal_IOC_2014.pdfee8e7f922ff541184cf10b4f43e70f8eMD52TEXTpedro_teixeiraetal_IOC_2014.pdf.txtpedro_teixeiraetal_IOC_2014.pdf.txtExtracted texttext/plain57887https://www.arca.fiocruz.br/bitstream/icict/10262/3/pedro_teixeiraetal_IOC_2014.pdf.txt1f2d89b5c85eb40ba9baba55d5ce01caMD53icict/102622022-06-24 12:17:33.527oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:17:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Structural and Molecular Modeling Features of P2X Receptors
title Structural and Molecular Modeling Features of P2X Receptors
spellingShingle Structural and Molecular Modeling Features of P2X Receptors
Alves, Luiz Anastácio
P2X7 receptor
Ion channel activity
Patch-clamp
title_short Structural and Molecular Modeling Features of P2X Receptors
title_full Structural and Molecular Modeling Features of P2X Receptors
title_fullStr Structural and Molecular Modeling Features of P2X Receptors
title_full_unstemmed Structural and Molecular Modeling Features of P2X Receptors
title_sort Structural and Molecular Modeling Features of P2X Receptors
author Alves, Luiz Anastácio
author_facet Alves, Luiz Anastácio
Silva, João Hermínio Martins da
Ferreira, Dinarte Neto Moreira
Fidalgo Neto, Antonio Augusto
Teixeira, Pedro Celso Nogueira
Souza, Cristina Alves Magalhães de
Caffarena, Ernesto Raúl
Freitas, Mônica Santos de
author_role author
author2 Silva, João Hermínio Martins da
Ferreira, Dinarte Neto Moreira
Fidalgo Neto, Antonio Augusto
Teixeira, Pedro Celso Nogueira
Souza, Cristina Alves Magalhães de
Caffarena, Ernesto Raúl
Freitas, Mônica Santos de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alves, Luiz Anastácio
Silva, João Hermínio Martins da
Ferreira, Dinarte Neto Moreira
Fidalgo Neto, Antonio Augusto
Teixeira, Pedro Celso Nogueira
Souza, Cristina Alves Magalhães de
Caffarena, Ernesto Raúl
Freitas, Mônica Santos de
dc.subject.en.pt_BR.fl_str_mv P2X7 receptor
Ion channel activity
Patch-clamp
topic P2X7 receptor
Ion channel activity
Patch-clamp
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-08T14:08:45Z
dc.date.available.fl_str_mv 2015-05-08T14:08:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALVES, Luiz Anastacio et al. Structural and Molecular Modeling Features of P2X Receptors. International Journal of Molecular Sciences, n.15, p.4531-4549, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10262
dc.identifier.issn.pt_BR.fl_str_mv 1422-0067
dc.identifier.doi.pt_BR.fl_str_mv 10.3390/ijms15034531
identifier_str_mv ALVES, Luiz Anastacio et al. Structural and Molecular Modeling Features of P2X Receptors. International Journal of Molecular Sciences, n.15, p.4531-4549, 2014.
1422-0067
10.3390/ijms15034531
url https://www.arca.fiocruz.br/handle/icict/10262
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/10262/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/10262/2/pedro_teixeiraetal_IOC_2014.pdf
https://www.arca.fiocruz.br/bitstream/icict/10262/3/pedro_teixeiraetal_IOC_2014.pdf.txt
bitstream.checksum.fl_str_mv 7d48279ffeed55da8dfe2f8e81f3b81f
ee8e7f922ff541184cf10b4f43e70f8e
1f2d89b5c85eb40ba9baba55d5ce01ca
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324659117096960

Registros relacionados