Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15964 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
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Castro, Solange L. deBatista, Denise G. J.Batista, Marcos M.Batista, WandersonDaliry, AnissaSouza, Elen M. deMenna-Barreto, Rubem F. S.Oliveira, Gabriel M.Salomão, KellySilva, Cristiane F.Silva, Patricia B.Soeiro, Maria de Nazaré C.2016-09-27T14:12:46Z2016-09-27T14:12:46Z2011CASTRO, Solange C. de; et al. Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones. Molecular Biology International, v.2011, Article ID306928, 13p, 2011.2090-2182https://www.arca.fiocruz.br/handle/icict/1596410.4061/2011/3069282090-2190engHindawi Publishing CorporationDoença de ChagasTrypanosoma cruziQuimioterapia experimentalNaftoquinonasAmidinasChagas diseaseTrypanosoma cruziExperimental ChemotherapyAmidinesNaphthoquinonesExperimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinonesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Chagas disease (CD), caused by Trypanosoma cruzi, affects approximately eight million individuals in Latin America and is emerging in nonendemic areas due to the globalisation of immigration and nonvectorial transmission routes. Although CD represents an important public health problem, resulting in high morbidity and considerable mortality rates, few investments have been allocated towards developing novel anti-T. cruzi agents. The available therapy for CD is based on two nitro derivatives (benznidazole (Bz) and nifurtimox (Nf)) developed more than four decades ago. Both are far from ideal due to substantial secondary side effects, limited efficacy against different parasite isolates, long-term therapy, and their well-known poor activity in the late chronic phase. These drawbacks justify the urgent need to identify better drugs to treat chagasic patients. Although several classes of natural and synthetic compounds have been reported to act in vitro and in vivo on T. cruzi, since the introduction of Bz and Nf, only a few drugs, such as allopurinol and a few sterol inhibitors, have moved to clinical trials. This reflects, at least in part, the absence of well-established universal protocols to screen and compare drug activity. In addition, a large number of in vitro studies have been conducted using only epimastigotes and trypomastigotes instead of evaluating compounds' activities against intracellular amastigotes, which are the reproductive forms in the vertebrate host and are thus an important determinant in the selection and identification of effective compounds for further in vivo analysis. In addition, due to pharmacokinetics and absorption, distribution, metabolism, and excretion characteristics, several compounds that were promising in vitro have not been as effective as Nf or Bz in animal models of T. cruzi infection. In the last two decades, our team has collaborated with different medicinal chemistry groups to develop preclinical studies for CD and investigate the in vitro and in vivo efficacy, toxicity, selectivity, and parasite targets of different classes of natural and synthetic compounds. Some of these results will be briefly presented, focusing primarily on diamidines and related compounds and naphthoquinone derivatives that showed the most promising efficacy against T. cruzi.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15964/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALwanderson_batista_etal_IOC_2011.pdfwanderson_batista_etal_IOC_2011.pdfapplication/pdf1214776https://www.arca.fiocruz.br/bitstream/icict/15964/2/wanderson_batista_etal_IOC_2011.pdfd158b1dcb31d94388fe3f2e1d521bd43MD52TEXTwanderson_batista_etal_IOC_2011.pdf.txtwanderson_batista_etal_IOC_2011.pdf.txtExtracted texttext/plain82282https://www.arca.fiocruz.br/bitstream/icict/15964/3/wanderson_batista_etal_IOC_2011.pdf.txtbb772e5306b357552b9df3f6890d3095MD53icict/159642018-04-02 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| dc.title.pt_BR.fl_str_mv |
Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones |
| title |
Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones |
| spellingShingle |
Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones Castro, Solange L. de Doença de Chagas Trypanosoma cruzi Quimioterapia experimental Naftoquinonas Amidinas Chagas disease Trypanosoma cruzi Experimental Chemotherapy Amidines Naphthoquinones |
| title_short |
Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones |
| title_full |
Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones |
| title_fullStr |
Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones |
| title_full_unstemmed |
Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones |
| title_sort |
Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones |
| author |
Castro, Solange L. de |
| author_facet |
Castro, Solange L. de Batista, Denise G. J. Batista, Marcos M. Batista, Wanderson Daliry, Anissa Souza, Elen M. de Menna-Barreto, Rubem F. S. Oliveira, Gabriel M. Salomão, Kelly Silva, Cristiane F. Silva, Patricia B. Soeiro, Maria de Nazaré C. |
| author_role |
author |
| author2 |
Batista, Denise G. J. Batista, Marcos M. Batista, Wanderson Daliry, Anissa Souza, Elen M. de Menna-Barreto, Rubem F. S. Oliveira, Gabriel M. Salomão, Kelly Silva, Cristiane F. Silva, Patricia B. Soeiro, Maria de Nazaré C. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Castro, Solange L. de Batista, Denise G. J. Batista, Marcos M. Batista, Wanderson Daliry, Anissa Souza, Elen M. de Menna-Barreto, Rubem F. S. Oliveira, Gabriel M. Salomão, Kelly Silva, Cristiane F. Silva, Patricia B. Soeiro, Maria de Nazaré C. |
| dc.subject.other.pt_BR.fl_str_mv |
Doença de Chagas Trypanosoma cruzi Quimioterapia experimental Naftoquinonas Amidinas |
| topic |
Doença de Chagas Trypanosoma cruzi Quimioterapia experimental Naftoquinonas Amidinas Chagas disease Trypanosoma cruzi Experimental Chemotherapy Amidines Naphthoquinones |
| dc.subject.en.pt_BR.fl_str_mv |
Chagas disease Trypanosoma cruzi Experimental Chemotherapy Amidines Naphthoquinones |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
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2011 |
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2011 |
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2016-09-27T14:12:46Z |
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2016-09-27T14:12:46Z |
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info:eu-repo/semantics/article |
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CASTRO, Solange C. de; et al. Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones. Molecular Biology International, v.2011, Article ID306928, 13p, 2011. |
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https://www.arca.fiocruz.br/handle/icict/15964 |
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2090-2182 |
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10.4061/2011/306928 |
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2090-2190 |
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CASTRO, Solange C. de; et al. Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones. Molecular Biology International, v.2011, Article ID306928, 13p, 2011. 2090-2182 10.4061/2011/306928 2090-2190 |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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